A new approach to diagnosing and researching developmental prosopagnosia:Excluded cases are impaired too

Developmental prosopagnosia is characterized by severe, lifelong difficulties when recognizing facial identity. Unfortunately, the most common diagnostic assessment (Cambridge Face Memory Test) misses 50–65% of individuals who believe that they have this condition. This results in such excluded cases’ absence from scientific knowledge, effect sizes of impairment potentially overestimated, treatment efficacy underrated, and may elicit in them a negative experience of research. To estimate their symptomology and group-level impairments in face processing, we recruited a large cohort who believes that they have prosopagnosia. Matching prior reports, 56% did not meet criteria on the Cambridge Face Memory Test. However, the severity of their prosopagnosia symptoms and holistic perception deficits were comparable to those who did meet criteria. Excluded cases also exhibited face perception and memory impairments that were roughly one standard deviation below neurotypical norms, indicating the presence of objective problems. As the prosopagnosia index correctly classified virtually every case, we propose it should be the primary method for providing a diagnosis, prior to subtype categorization. We present researchers with a plan on how they can analyze these excluded prosopagnosia cases in their future work without negatively impacting their traditional findings. We anticipate such inclusion will enhance scientific knowledge, more accurately estimate effect sizes of impairments and treatments, and identify commonalities and distinctions between these different forms of prosopagnosia. Owing to their atypicalities in visual perception, we recommend that the prosopagnosia index should be used to screen out potential prosopagnosia cases from broader vision research

How emotional are emoji?: Exploring the effect of emotional valence on the processing of emoji stimuli.

Emoji are vastly becoming an integral part of everyday communication, yet little is understood about the extent to which these are processed emotionally. Previous research shows that there is a processing advantage for emotionally-valenced words over neutral ones, therefore if emoji are indeed emotional, one could expect an equivalent processing advantage. In the Pilot Study, participants (N = 44) completed a lexical decision task to explore accuracy and response latency of word, face and emoji stimuli. This stimuli varied in emotional valence (positive vs. neutral). Main effects were found for stimuli type and valence on both accuracy and latency, although the interaction for accuracy was not significant. That is, there were processing advantages of positively-valenced stimuli over neutral ones, across all stimuli types. Also, faces and emoji were processed significantly more quickly than words, and latencies between face and emoji stimuli, irrespective of valence were largely equivalent. The Main Study recruited 33 participants to undertake a modified and extended version of the lexical decision task, which included three valence conditions (positive, negative and neutral) per stimuli type. Although no main effects were found for accuracy, there was a significant main effect found for stimuli but not for valence on latency. Namely, that word stimuli irrespective of valence were processed significantly more slowly than face or emoji stimuli. There was not a significant interaction between stimuli and valence, however. Therefore, overall although there was partial support for a processing advantage of emoji stimuli, this was not replicated across the studies reported here, suggesting additional work may be needed to corroborate further evidenc

INGENIOUS Survival at SMASHfestUK

This case study was written up and reported online on the website for the Queen Elizabeth Prize for Engineering - Create the Future series. It was written by QEPrize writer Sarah Gaunt and Wyn Griffiths of Middlesex University and explores the genesis of SMASHfestUK and the support of the Royal Academy of Engineering INGENIOUS programme in helping SMASHfestUK develop and manifest an interactive artistic installation; 'Survival Village.' The 'Survival Village' was a physical installation which was co-designed and built with young people and their families attending a SMASHfestUK (science and arts festival) event. The installation evoked a post-apocalyptic survivor's camp and the audience were invited to build infrastructure and equipment (such as rocket stoves and radiation based heating systems) for survival out of available waste and upcycled materials. The picture in the URL shows a water filtration system that has been created out of readily available mineral materials

Histories of Medieval European Literatures: New Patterns of Representation and Explanation

Interfaces: A Journal of Medieval European Literatures is invested in bringing together the linguistic, literary, and historical expertise to take a European approach to medieval literature. The journal aims to establish a forum both for articles which move across literatures (plural) and also, more ambitiously, to foster reflections on a more elusive, but no longer entirely absent, object, European medieval literature (singular).In line with the journal’s scope and vision to promote integrated approaches to European medieval literatures, we begin by facing head-on the multiple challenges of devising new types of narratives about medieval textual cultures. We have invited papers which take a wider regional perspective and move across medieval Europe as well as papers which bring an explicitly European perspective to more specific topics (with a tighter thematic, chronological, geographic, or linguistic focus)

Telehealth for patients at high risk of cardiovascular disease: pragmatic randomised controlled trial

Objective: To assess whether non-clinical staff can effectively manage people at high risk of cardiovascular disease using digital health technologies. Design: Pragmatic, multicentre, randomised controlled trial. Setting: 42 general practices in three areas of England. Participants: Between 3 December 2012 and 23 July 2013 we recruited 641 adults aged 40 to 74 years with a 10 year cardiovascular disease risk of 20% or more, no previous cardiovascular event, at least one modifiable risk factor (systolic blood pressure ≥140 mm Hg, body mass index ≥30, current smoker), and access to a telephone, the internet, and email. Participants were individually allocated to intervention (n=325) or control (n=316) groups using automated randomisation stratified by site, minimised by practice and baseline risk score. Interventions: Intervention was the Healthlines service (alongside usual care), comprising regular telephone calls from trained lay health advisors following scripts generated by interactive software. Advisors facilitated self-management by supporting participants to use online resources to reduce risk factors, and sought to optimise drug use, improve treatment adherence, and encourage healthier lifestyles. The control group comprised usual care alone. Main outcome measures: The primary outcome was the proportion of participants responding to treatment, defined as maintaining or reducing their cardiovascular risk after 12 months. Outcomes were collected six and 12 months after randomisation and analysed masked. Participants were not masked. Results: 50% (148/295) of participants in the intervention group responded to treatment compared with 43% (124/291) in the control group (adjusted odds ratio 1.3, 95% confidence interval 1.0 to 1.9; number needed to treat=13); a difference possibly due to chance (P=0.08). The intervention was associated with reductions in blood pressure (difference in mean systolic −2.7 mm Hg (95% confidence interval −4.7 to −0.6 mm Hg), mean diastolic −2.8 (−4.0 to −1.6 mm Hg); weight −1.0 kg (−1.8 to −0.3 kg), and body mass index −0.4 (−0.6 to −0.1) but not cholesterol −0.1 (−0.2 to 0.0), smoking status (adjusted odds ratio 0.4, 0.2 to 1.0), or overall cardiovascular risk as a continuous measure (−0.4, −1.2 to 0.3)). The intervention was associated with improvements in diet, physical activity, drug adherence, and satisfaction with access to care, treatment received, and care coordination. One serious related adverse event occurred, when a participant was admitted to hospital with low blood pressure. Conclusions: This evidence based telehealth approach was associated with small clinical benefits for a minority of people with high cardiovascular risk, and there was no overall improvement in average risk. The Healthlines service was, however, associated with improvements in some risk behaviours, and in perceptions of support and access to care

ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas.

Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network