Effects of Gabaergic phenols on phospholipid bilayers as evaluated by 1H-NMR

The phenols propofol and thymol, and lately carvacrol, eugenol and chlorothymol, have been shown to act as positive allosteric modulators on GABAA receptor, which is the main inhibitory receptor of the central nervous system. GABAA receptor is an intrinsic membrane protein which activity may be affected by surface-active compounds and by physical changes in the membrane. Recently, we demonstrated that these phenols interacted with the lipid membrane phase, suggesting their anesthetic activity could be the combined result of their specific (with receptor proteins) as well as nonspecific (with surrounding lipid molecules) interaction modulating the supramolecular organization of the receptor environment. In the current study, by using 1H-NMR spectroscopy, we have investigated the effects of the insertion and the possible preferential location of the five phenol derivatives with GABAergic activity on EPC membranes. The results indicate that all compounds are able to insert in EPC phospholipid vesicles and to locate in the region between the polar group (choline molecule), the glycerol and the first atoms of the acyl chains, being the more lipophilic compounds (propofol and chlorothymol) that seem to prefer a deeper bilayer insertion. The location of the phenol molecules would reduce the repulsive forces among phospholipids head groups allowing closer molecular packing and finally diminishing the mobility of the hydrocarbon chains, as revealed by 1H spin relaxation times.Fil: Reiner, Gabriela de Las Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidade Estadual de Campinas; Brasil. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Fraceto, Leonardo Fernandes. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Paula, Eneida de. Universidade Estadual de Campinas; BrasilFil: Perillo, Maria Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Garcia, Daniel Asmed. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentin

Fotografia e profilaxia social : a visão do «outro» nas campanhas da LPPS

A Liga Portuguesa de Profilaxia Social é, desde 1924, uma instituição vocacionada para a defesa da saúde pública. Desenvolveu um programa de ação orientado para a sensibilização da população aos perigos das doenças contagiosas e de algumas práticas sociais, questionando o campo físico, psicológico e moral. Na sua ação direta com os «outros», a Liga usou meios de comunicação como a fotografia e o cartaz, recorrendo ainda ao cinema. O artigo pretende estudar a sua produção visual com a intenção de analisar a mensagem emitida relativa à educação para a saúde no período de entre as duas guerras mundiais, focalizando os cartazes que a Liga produziu para o efeito, bem como os cartazes estrangeiros que funcionaram com modelos inspiradores

Fotografia e profilaxia social : a visão do «outro» nas campanhas da LPPS

A Liga Portuguesa de Profilaxia Social é, desde 1924, uma instituição vocacionada para a defesa da saúde pública. Desenvolveu um programa de ação orientado para a sensibilização da população aos perigos das doenças contagiosas e de algumas práticas sociais, questionando o campo físico, psicológico e moral. Na sua ação direta com os «outros», a Liga usou meios de comunicação como a fotografia e o cartaz, recorrendo ainda ao cinema. O artigo pretende estudar a sua produção visual com a intenção de analisar a mensagem emitida relativa à educação para a saúde no período de entre as duas guerras mundiais, focalizando os cartazes que a Liga produziu para o efeito, bem como os cartazes estrangeiros que funcionaram com modelos inspiradores

Carteles en la comunicación visual para la educación sanitaria en el período de entreguerras

El avance que se hizo en el campo de la investigación médica durante la IGM, sumado a la ola de humanismo propia del período post-bélico y la propagación en 1918 de algunas enfermedades venéreas y otras como la gripe, hizo que se desarrollaran políticas de educación pública con el fin deconcienciar a la población de la importancia del cuidado profiláctico. En este contexto nació la Liga Portuguesa de Profilaxia Social, que surgió en Oporto en el año 1924 por iniciativa de tres jóvenes médicos que, desde la perspectiva de salud pública, animados por la preocupación de prevenirenfermedades derivadas del contacto con el entorno y prestando especial atención a accidentes domésticos, enfermedades contagiosas epidémicas y endémicas, desarrollaron un programa de acción -que hoy denominaríamos de educación para la salud- con el fin de sensibilizar a la poblacióny así minimizar el riesgo de contagio, trabajando en el campo físico, psicológico y moral. Pero la Liga no discurrió por la discusión elistista sino que procuró enfrentarse directamente con estos problemas y, para llegar al mayor público posible, empleó distintos medios, entre ellos los carteles que, tras los resultados obtenidos en la Gran Guerra como concienciadores y motivadores, se convirtieron en una forma extensiva, barata y eficaz en el contexto de una ciudad, Oporto, con altas tasas de analfabetismo y en la que el acceso de los médicos al foco popular del problema era muy complicado. La comunicación que se presenta pretende estudiar esta producción visual con la intención de analizar el mensaje emitido en torno al tema de la educación para la salud en el período de entreguerras, analizando los carteles que se produjeron en la Liga y aquellos extranjeros que sirvieron de inspiradores.The progress made in the field of medical research during the I Word War, the wave of humanism own post- war period in 1918 and the spread of some STDs and other flu-like, did that develop education policies public in order to raise awareness of the importance of prophylactic care. In this context the Portuguese League for Social Prophylaxis was born, which emerged in Oporto in 1924 by initiative of three young doctors from the public health perspective, inspired by a concern to prevent illness from contact with the environment and with special attention to domestic accidents, epidemic and endemic infectious diseases, and developed a program of action which now call for healtheducation in order to raise awareness and minimize the risk of contagion, working on the physical,psychological and field moral. But the League was not a mere elitist discussion but sought directly confront these problems and to reach the widest possible audience used various means, including posters, after the results of the Great War as raise an awareness and motivating, became extensive, cheap and effective in the context of a city, Oporto, with high rates of illiteracy, and in which physicians access to popular focus of the problem was very complicated form. Communication presented aims tostudy this visual production with the intention of analyzing the message issued on the subject of health education in the interwar period, analyzing the posters that were produced in the League and those produced abroad that they were the inspiration

Contributions on Transmitarrays for Far-Field Applications

XI Encuentro Ibérico de Electromagnetismo Computacional-IIEC, 8-11 de noviembre de 2016, Asturias (España)Different contributions made to the development of Transmitarrays (TA) for Far-Filed applications are presented in this contribution. Firstly, a unit cell, based on four patches coupled by a slot or a symmetric cross, is introduced, and then, an arraybased model used to analyze a system formed by a TA and a planar lens in a time-efficient manner without using a full-wave method. Thus, both features are used to design and analyze the different prototypes reviewed in this contribution. That is, an ultra-thin planar lenses based on a 2-bit unit cell and a dualpolarized TA that has been designed in order to be used in polarized agile antenna. Thus, by rotating the feed of the system, a linear polarized antenna, it is possible to obtain any kind of polarization, form linear to circular. Finally, this TA has been used in a multibeam application fed with a network of quasi-yagi antenna

Ball Grid Array Module with Integrated Shaped Lens for 5G Backhaul/Fronthaul Communications in F-Band

In this paper, we propose a ball grid array (BGA) module with an integrated 3-D-printed plastic lens antenna for application in a dedicated 130 GHz OOK transceiver that targets the area of 5G backhaul/fronthaul systems. The main design goal was the full integration of a small footprint antenna with an energy-efficient transceiver. The antenna system must be compact and cost effective while delivering an approximately 30 dBi gain in the working band, defined as 120 to 140 GHz. Accordingly, a 2×2 array of aperture-coupled patch antennas was designed in the 7×7×0.362 mm3 BGA module as the feed antenna of the lens. This achieved a 7.8 dBi realized gain, broadside polarization purity above 20 dB, and over 55% total efficiency from 110 to 140 GHz (20% bandwidth). A plastic elliptical lens 40 mm in diameter and 42.3 mm in height was placed on top of the BGA module. The antenna achieved a return loss better than ?10 dB and a 28 dBi realized gain from 114 to 140 GHz. Finally, active measurements demonstrated a >12 Gbps Tx/Rx link at 5 m with bit error rate (BER) < 10?6 at 1.6 pJ/b/m. These results pave the way for future cost-effective, energy-efficient, high-data rate backhaul/fronthaul systems for 5G communications.info:eu-repo/semantics/acceptedVersio

The Fungal Cell Wall : Structure, Biosynthesis, and Function

N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M. are part of the MRC Centre for Medical Mycology. J.P.L. acknowledges support from ANR, Aviesan, and FRM.Peer reviewedPublisher PD

Bioinformatics Training Network (BTN): a community resource for bioinformatics trainers

Funding bodies are increasingly recognizing the need to provide graduates and researchers with access to short intensive courses in a variety of disciplines, in order both to improve the general skills base and to provide solid foundations on which researchers may build their careers. In response to the development of ‘high-throughput biology’, the need for training in the field of bioinformatics, in particular, is seeing a resurgence: it has been defined as a key priority by many Institutions and research programmes and is now an important component of many grant proposals. Nevertheless, when it comes to planning and preparing to meet such training needs, tension arises between the reward structures that predominate in the scientific community which compel individuals to publish or perish, and the time that must be devoted to the design, delivery and maintenance of high-quality training materials. Conversely, there is much relevant teaching material and training expertise available worldwide that, were it properly organized, could be exploited by anyone who needs to provide training or needs to set up a new course. To do this, however, the materials would have to be centralized in a database and clearly tagged in relation to target audiences, learning objectives, etc. Ideally, they would also be peer reviewed, and easily and efficiently accessible for downloading. Here, we present the Bioinformatics Training Network (BTN), a new enterprise that has been initiated to address these needs and review it, respectively, to similar initiatives and collections