Solar Neutrinos. II. Experimental

A method is described for observing solar neutrinos from the reaction Cl/ sup 37/( nu ,e/sup -/)Ar/sup 37/ in C/sub 2/Cl/sub 4/. Two 5 00-gal tanks of C/ sub 2/Cl/sub 4/ were placed in a limestone mine (1800 m.w.e.) and the resulting Ar/sup 37/ activity induced by cosmic mesons( mu ) was measured to determine the necessary conditions for solar neutrino observations. (R.E.U.

The Observations Of The X-Ray Source Hz Herculis-Hercules X-1

NASAESASRCAstronom

A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus

Disruption of Golgi -mannosidase II activity can result in type II congenital dyserythropoietic anemia and can induce lupus-like autoimmunity in mice. Here, we isolate a mutant human embryonic kidney (HEK) 293T cell line, called Lec36, that displays sensitivity to ricin that lies between the parental HEK 293T cells, whose secreted and membrane-expressed proteins are dominated by complex-type glycosylation, and 293S Lec1 cells, which only produce oligomannose-type N-linked glycans. The stem cell marker, 19A, was transiently expressed in the HEK 293T Lec36 cells, and in parental HEK 293T cells with and without the potent Golgi -mannosidase II inhibitor, swainsonine. Negative-ion nano-electrospray ionization mass spectra of the 19A N-linked glycans from HEK 293T Lec36 and swainsonine-treated HEK 293T cells were qualitatively indistinguishable and, as shown by collision-induced dissociation spectra, dominated by hybrid-type glycosylation. Nucleotide sequencing revealed mutations in each allele of MAN2A1, the gene encoding Golgi -mannosidase II: a point mutation in one allele mapping to the active site and an in-frame deletion of twelve-nucleotides in the other. Expression of wild-type but not the mutant MAN2A1 alleles in Lec36 cells restored processing of the 19A reporter glycoprotein to complex-type glycosylation. The Lec36 cell line will be useful for expressing therapeutic glycoproteins with hybrid-type glycans and provides a sensitive host for detecting mutations in human MAN2A1 causing type II congenital dyserythropoietic anemia

The effect of type I migration on the formation of terrestrial planets in hot-Jupiter systems

Context: Our previous models of a giant planet migrating through an inner protoplanet/planetesimal disk find that the giant shepherds a portion of the material it encounters into interior orbits, whilst scattering the rest into external orbits. Scattering tends to dominate, leaving behind abundant material that can accrete into terrestrial planets. Aims: We add to the possible realism of our model by simulating type I migration forces which cause an inward drift, and strong eccentricity and inclination damping of protoplanetary bodies. This extra dissipation might be expected to enhance shepherding at the expense of scattering, possibly modifying our previous conclusions. Methods: We employ an N-body code that is linked to a viscous gas disk algorithm capable of simulating: gas accretion onto the central star; gap formation in the vicinity of the giant planet; type II migration of the giant planet; type I migration of protoplanets; and the effect of gas drag on planetesimals. We use the code to re-run three scenarios from a previous work where type I migration was not included. Results: The additional dissipation introduced by type I migration enhances the inward shepherding of material but does not severely reduce scattering. We find that > 50% of the solids disk material still survives the migration in scattered exterior orbits: most of it well placed to complete terrestrial planet formation at < 3 AU. The shepherded portion of the disk accretes into hot-Earths, which survive in interior orbits for the duration of our simulations. Conclusions: Water-rich terrestrial planets can form in the habitable zones of hot-Jupiter systems and hot-Earths and hot-Neptunes may also be present. These systems should be targets of future planet search missions.Comment: Accepted by A&A. 15 pages, 14 figures. Higher resolution pdf available at http://www.users.globalnet.co.uk/~mfogg/7950fogg.pd

The H2 velocity structure of inner knots in HH 212: asymmetries and rotation

High-resolution R~50 000 long-slit spectroscopy of the inner knots of the highly symmetrical protostellar outflow HH 212 was obtained in the 1-0 S(1) line of H2 at 2.12 micron with a spatial resolution of ~0.45 arcsec. At the resulting velocity resolution of ~6 km s-1, multiple slit oriented observations of the northern first knot NK1 clearly show double-peaked line profiles consistent with either a radiative bow shock or dual (forward and reverse) shocks. In contrast, the velocity distribution of the southern first knot SK1 remains single-peaked, suggesting a significantly lower jet velocity and possibly a different density variation in the jet pulses in the southern flow compared to the northern flow. Comparison with a semi-empirical analytical model of bow shock emission allows us to constrain parameters such as the bow inclination to the line of sight, the bow shock and jet velocities for each flow. Although a few features are not reproduced by this model, it confirms the presence of several dynamical and kinematical asymmetries between opposite sides of the HH 212 bipolar jet. The position-velocity diagrams of both knots exhibit complex dynamics that are broadly consistent with emission from a bow shock and/or jet shock, which does not exclude jet rotation, although a clear signature of jet rotation in HH 212 is missing. Alternative interpretations of the variation of radial velocity across these knots, such as a variation in the jet orientation, as well as for the velocity asymmetries between the flows, are also considered. The presence of a correlation between flow velocity and collimation in each flow is suggested.Comment: Accepted for publication in Astronomy and Astrophysics, 16 page

Parallel Measurement and Modeling of Transport in the Darht II Beamline on ETA II

To successfully tune the DARHT II transport beamline requires the close coupling of a model of the beam transport and the measurement of the beam observables as the beam conditions and magnet settings are varied. For the ETA II experiment using the DARHT II beamline components this was achieved using the SUICIDE (Simple User Interface Connecting to an Integrated Data Environment) data analysis environment and the FITS (Fully Integrated Transport Simulation) model. The SUICIDE environment has direct access to the experimental beam transport data at acquisition and the FITS predictions of the transport for immediate comparison. The FITS model is coupled into the control system where it can read magnet current settings for real time modeling. We find this integrated coupling is essential for model verification and the successful development of a tuning aid for the efficient convergence on a useable tune. We show the real time comparisons of simulation and experiment and explore the successes and limitations of this close coupled approach

Security Implications of Running Windows Software on a Linux System Using Wine

Linux is considered to be less prone to malware compared to other operating systems, and as a result Linux users rarely run anti-malware. However, many popular software applications released on other platforms cannot run natively on Linux. Wine is a popular compatibility layer for running Windows programs on Linux. The level of security risk that Wine poses to Linux users is largely undocumented. This project was conducted to assess the security implications of using Wine, and to determine if any specific types of malware or malware behavior have a significant effect on the malware being successful in Wine. Dynamic analysis (both automated and manual) was applied to 30 malware samples both in a Windows environment and Linux environment running Wine. Behavior analyzed included file system, registry, and network access, and the spawning of processes, and services. The behavior was compared to determine malware success in Wine. The study results provide evidence that Wine can pose serious security implications when used to run Windows software in a Linux environment. Five samples of Windows malware were run successfully through Wine on a Linux system. No significant relationships were discovered between the success of the malware and its high-level behavior or malware type. However, certain API calls could not be recreated in a Linux environment, and led to failure of malware to execute via Wine. This suggests that particular malware samples that utilize these API calls will never run completely successfully in a Linux environment. As a consequence, the success of some samples can be determined from observing the API calls when run within a Windows environment

Method and apparatus for electromagnetic powder deposition

The present invention provides a method for depositing powder particles on a substrate. The method comprises forming a planar plasma armature, accelerating the plasma armature, accelerating a column of gas with the plasma armature; and accelerating the powder particles with the column of gas. The present invention provides for a railgun, comprising first and second conducting rails, and first and second insulating rails. The insulating and conducting rails form a bore of the railgun. The first and second conducting rails are separated by the insulating rails. At least one of the rails has a port in the wall thereof, the port is adapted to introducing powder particles into the bore.Board of Regents, University of Texas Syste

Challenges of and Insights into Acid-Catalyzed Transformations of Sugars

The selective transformation of hexose and pentose sugars to intermediate platform chemicals, such as furans, is an essential step in the conversion of cellulosic and hemicellulosic biomass to biofuels and biochemicals. Yet, many challenges in achieving commercially viable processes remain. In this feature article, we outline challenges that need to be overcome to enable these transformations. Then, we present the newly introduced acid-catalyzed isomerization of aldose sugars to ketose sugars via a class of solid Lewis acid catalysts (e.g., Sn-Beta, Ti-Beta). We elucidate mechanistic insights arising from subnanometer cooperativity and solvent effects that can be controlled to tune reaction pathways and selectivity and draw parallels between heterogeneous and homogeneous Lewis acid catalysts. Subsequently, we discuss fructose dehydration to 5-hydroxyl-methylfurfural (HMF) via homogeneous and heterogeneous Brønsted acid-catalyzed chemistry. We show how fundamental insights arising from the combination of kinetics, spectroscopy, and multiscale simulations rationalize the improved yield of HMF in water–organic cosolvents. The stability of heterogeneous Lewis acid catalysts under low pH enables tandem Brønsted and Lewis acid-catalyzed reactions in a single pot that overcomes equilibrium limitations and gives a high HMF yield starting from sugar raw materials. Additionally, we provide an overview of multicomponent adsorption of biomass derivatives from solution in microporous materials and discuss how structure–property relations can lead to superior micro- and micromesoporous carbon adsorbents for reactive adsorption toward high HMF yield. Finally, we provide an outlook for the field