Participación de los trabajadores en las empresas españolas, con especial atención a su aportación en la toma de decisiones

Análisis de la economía social; examen de los diferentes tipos de participación de los trabajadores; y estudio de la posibilidad de su mayor aportación en la toma de decisiones en las empresas en España.Grado en Relaciones Laborales y Recursos Humano

Fuzzy rules model for global warming decision suport

Ponencia presentada en: VI Congreso Internacional de la Asociación Española de Climatología celebrado en Tarragona del 8 al 11 de octubre de 2008.[EN]In this work a simple box model of the ocean-atmosphere is used to asses the response of the coupled system to the projected increase in the amount of carbon dioxide, by varying internal model parameters, within plausible ranges, as well as the thermal forcing associated with the greenhouse gases. The values of temperature increase are used to build fuzzy logic models based on the Fuzzy Inductive Reasoning (FIR) methodology that are able to deal with the uncertainties associated to the box model parameters. FIR is a data driven methodology that uses fuzzy and pattern recognition techniques to infer system models and to predict their future behavior.[ES]En este trabajo se utiliza un modelo simple del sistema océano-atmósfera para obtener valores de temperatura promediados globalmente. En este modelo, la temperatura es una función del calor agregado al sistema, de la sensitividad de la atmósfera y de la difusividad del océano. A partir de los campos de temperatura obtenidos, se construye un modelo basado en lógica difusa, concretamente usando la metodología del Razonamiento Inductivo Difuso (FIR, por las siglas en inglés), el cual es capaz de predecir el cambio de temperatura global con una gran precisión. Sin embargo, el modelo FIR no permite una interpretación suficientemente sencilla de la dinámica del sistema para que sea útil a los tomadores de decisiones

Diseño y construcción de una estación de monitorio climático con almacenamiento y transmisión de datos

El presente Trabajo monográfico, muestra el diseño de una estación de monitoreo climático, que consiste en censar los datos siguientes: temperatura, humedad relativa, redacción solar, pluviosidad, velocidad y dirección del viento, presión atmosférica y la contaminación del ambiente o también por las siglas CO2

Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus

Objectives: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that share clinical and immunological characteristics. To date, several shared SSc- RA loci have been identified independently. In this study, we aimed to systematically search for new common SSc-RA loci through an inter-disease meta-GWAS strategy. Methods: We performed a meta-analysis combining GWAS datasets of SSc and RA using a strategy that allowed identification of loci with both same-direction and opposingdirection allelic effects. The top single-nucleotide polymorphisms (SNPs) were followed-up in independent SSc and RA case-control cohorts. This allowed us to increase the sample size to a total of 8,830 SSc patients, 16,870 RA patients and 43,393 controls. Results: The cross-disease meta-analysis of the GWAS datasets identified several loci with nominal association signals (P-value < 5 x 10-6), which also showed evidence of association in the disease-specific GWAS scan. These loci included several genomic regions not previously reported as shared loci, besides risk factors associated with both diseases in previous studies. The follow-up of the putatively new SSc-RA loci identified IRF4 as a shared risk factor for these two diseases (Pcombined = 3.29 x 10-12). In addition, the analysis of the biological relevance of the known SSc-RA shared loci pointed to the type I interferon and the interleukin 12 signaling pathways as the main common etiopathogenic factors. Conclusions: Our study has identified a novel shared locus, IRF4, for SSc and RA and highlighted the usefulness of cross-disease GWAS meta-analysis in the identification of common risk loci

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), "A way of making Europe".Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations from CN parity of C4A and C4B augmented risk. The protection contributed per copy of C4A and C4B differed by sex. Stronger protection was afforded by C4A in men and by C4B in women. C4 CN correlated well with its gene expression and serum protein levels, and less C4 was detected for both in SSc patients. Conditioned analysis suggests that C4 genetics strongly contributes to the SSc association within the major histocompatibility complex locus and highlights classical alleles and amino acid variants of HLA-DRB1 and HLA-DPB1 as C4-independent signals

Dimensionamiento de una instalación fotovoltaica de generación distribuida aislada de la red para autoconsumo con sistema de almacenamiento en una vivienda unifamiliar en la Provincia del Guayas y análisis de viabilidad técnica y económica

En esta tesis se analiza la opción de realizar una instalación fotovoltaica aislada en una vivienda unifamiliar en el Recinto el Achiote en la Provincia del Guayas con el propósito de dar a conocer la viabilidad técnica y económica de la instalación.GuayaquilIngeniero en Electricidad Especialización Potenci

AVA como estrategia didáctica para la Comprensión Lectora inferencial en los estudiantes del grado quinto del Centro Educativo Rural Los Encantos Guaimaral.

Este proyecto tiene como objeto caracterizar las competencias lectoras a nivel inferencial en los estudiantes, diseñar una estrategia didáctica basada en ABSD para fortalecer estas competencias, implementar esta estrategia mediante un Ambiente Virtual de Aprendizaje (AVA) y evaluar su impacto a través de una prueba de salida.Los resultados muestran que el ABSD, implementado a través de un AVA, tuvo un impacto positivo en el fortalecimiento de las competencias lectoras inferenciales de los estudiantes.MaestríaMagíster en Recursos Digitales Aplicados a la Educació

Analysis of Oxidative Stress Enzymes and Structural and Functional Proteins on Human Aortic Tissue from Different Aortopathies

The role of oxidative stress in different aortopathies is evaluated. Thirty-two tissue samples from 18 men and 14 women were divided into: 4 control (C) subjects, 11 patients with systemic arterial hypertension (SAH), 4 with variants of Marfan’s syndrome (MV), 9 with Marfan’s syndrome (M), 2 with Turner’s syndrome, and 2 with Takayasu’s arteritis (TA). Aorta fragments were homogenized. Lipoperoxidation (LPO), copper-zinc and manganese superoxide dismutase (Mn and Cu-Zn-SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), endothelial nitric oxide synthase (eNOS), nitrates and nitrites (NO3−/NO2−), and type IV collagen, and laminin were evaluated. There was an increase in Mn- and Cu-Zn-SOD activity in SAH, MV, M, and Turner’s syndrome. There was also an increase in CAT activity in M and Turner’ syndrome. GPx and GST activity decreased and LPO increased in all groups. eNOS was decreased in SAH, MV, and M and NO3−/NO2− were increased in SAH and TA. Type IV collagen was decreased in Turner’s syndrome and TA. Laminin γ-1 was decreased in MV and increased in M. In conclusion, similarities and differences in oxidative stress in the different aortopathies studied including pathologies with aneurysms were found with alterations in SOD, CAT, GPx, GST, and eNOS activity that modify subendothelial basement membrane proteins