Modelado de interacciones sensibles al contexto mediante reglas en ambientes inteligentes

La Inteligencia Ambiental (AmI) propone la creación de entornos o ambientes inteligentes que se adapten a las necesidades, gustos e intereses de la gente que vive en ellos. Su principal objetivo es crear espacios constituidos por interfaces inteligentes e intuitivas integradas en objetos cotidianos con los que el usuario interacciona de forma natural y sin esfuerzo. Estas interfaces poseen capacidad para reconocer la presencia de diferentes usuarios, y modificar su comportamiento en función de la identidad de dicho usuario, sus necesidades y las características del contexto o entorno donde se encuentren. Dentro del campo de AmI, esta tesis se centra en el modelado de las interacciones que tienen lugar en este tipo de entornos. Para ello se hace necesario el estudio de un modelo, basado en una relación unívoca Tag-Objeto, en el que los objetos puedan tener asociadas más de una característica (en un único Tag), siendo el usuario el que decida con cuál de ellas interactúa a través de su terminal, teniendo en cuenta también los recursos disponibles en él y el historial de interacciones previas. Un entorno inteligente, además de contener objetos aumentados con Tag RFID, estará ubicado en una localización específica, es decir, en una zona geográfica bien definida. Esta característica hace posible otro tipo de interacciones, aquellas basadas en la localización. Así, un entorno o espacio inteligente no solamente proporcionará servicios al usuario cuando interaccione con alguno de los objetos que tiene definidos, sino que también es capaz de ofrecer otros servicios al usuario basándose simplemente en su localización. OBCAS propone una solución para el modelado de interacciones sensibles al contexto mediante reglas en ambientes inteligentes en la que las reglas no van a estar definidas de forma independiente, sino que van a formar parte del comportamiento de un conjunto de agentes. OBCAS está compuesto por un sistema multi-agente que tendrá un componente en el lado servidor y otro en el lado móvil. Todos los agentes que componen este sistema se comunican utilizando el protocolo FIPA y utilizando en el lenguaje de contenido el modelo ontológico definido en OBCAS-Ontology (Kernel). El kernel es una ontología cuya función es la representación e integración de los diferentes modelos (ontologías) y sus relaciones, de forma que representen a todos los elementos o artefactos que participan en la hipótesis para el modelado de escenarios y el desarrollo de aplicaciones NFC ubicuas y sensibles al contexto. Este sistema puede ser utilizado en cualquier aplicación en la que se realicen interacciones sensibles al contexto, y para verificar su eficacia se ha desarrollado AGATHA, un sistema de alarmas que monitoriza el cumplimiento de un conjunto de restricciones que están asociadas a ciertos usuarios. Esta aplicación ha demostrado la rapidez con la que el sistema es capaz de reaccionar y adaptarse al contexto del usuario, evitando por ejemplo que un agresor se acerque a una víctima o que un anciano se pierda.Ambient Intelligence (AmI) proposes the creation of smart environments able to adapt to the needs, tastes and interests of the people living in them. Its main objective is to create spaces constituted by intelligent and intuitive interfaces embedded in everyday objects with which the user interacts naturally and effortlessly. These interfaces have the capacity to recognize the presence of different users, and modify their behavior depending on the user's identity, needs and characteristics of the context or environment. Within the field of AmI, this thesis is focused on the modeling of the interactions that take place in these environments. In order to do so, it is necessary to study a model based on an univocal Tag-Object relationship, where objects can have associated more than one characteristic (to one tag), and the user decides which one to interact with through its terminal. The resources available in the terminal, and the history of previous interactions are also considered. A smart environment contains objects augmented with RFID Tag, and it is located in a specific location, i.e. a well-defined geographical area. This feature makes possible other interactions, those based on location. Hence, a space or smart environment not only provide intelligent services to the user when interacting with any of the objects that have been defined, but it is also able to provide the user with other services based simply on its location. OBCAS proposes a solution for modeling context-sensitive interactions in smart environments through rules, in which the rules will not be defined independently, but they will be part of the behavior of a set of agents. OBCAS comprises a multi-agent system that will have a component on the server side and another one on the mobile side. All agents making up the system use the FIPA protocol, and the ontological model OBCAS-Ontology (Kernel). The Kernel is an ontology whose function is the representation and integration of the different models (ontologies) and their relationships, so representing all the elements or artifacts involved in the scenario modeling and the development of ubiquitous and context-awareness NFC application. This system can be used in any application with context-aware interactions. In order to verify its efficacy has been developed AGATHA, an alarm system which monitors the performance of a set of constraints that are associated with certain users. This application has demonstrated the speed with which the system is able to react and adapt to the context of the user, e.g. preventing the approaching of an attacker to a victim

An Alert System for People Monitoring Based on Multi- Agents using Maps

This paper describes an alert system for people monitoring based on multi-agent using maps. This system monitors the users’ physical context using their mobile phone. The data acquisition is made using the available sensors on mobile phone. A set of agents on mobile phones are responsible for collecting, processing and sending data to the server. Another set of agents on server stores the data and checks the preconditions of the restrictions associated with the user, in order to trigger the appropriate alarms. These alarms are sent not only to the user that violates a restriction, but also to the one responsible for supervising the person monitored. The supervisor can control all the supervised people through a map interface with functionality such as sending a SMS or making a call directly from the map. The applicability of the system will be illustrated with an example for Alzheimer patient monitoring. These patients will carry on normal activity in the home environment or home for the elderly, monitored by their family or by nurses

Prevalence and Associated Factors of Low Bone Mineral Density in the Femoral Neck and Total Hip in Axial Spondyloarthritis: Data from the CASTRO Cohort

Studies on osteoporosis in axial spondyloarthritis (axSpA) have focused on the lumbar segment, and few studies have assessed bone mineral density (BMD) in the hip and femoral neck in these patients. The aim of this study was to evaluate the prevalence of low BMD and osteopenia in the total hip or femoral neck and the factors associated with these conditions in axSpA patients. This was a single-centre, observational, cross-sectional study among consecutive patients with axSpA according to the ASAS criteria from the CASTRO registry. All patients underwent total hip and femoral neck DXA BMD measurements. Low BMD was defined as a Z-score less than −1, and osteopenia was defined as a T-score less than −1. Multivariate logistic and generalised linear regressions were used to evaluate factors independently associated with low BMD and osteopenia in the hip or femoral neck and those associated with variability in BMD, respectively. A total of 117 patients were included, among which 30.8% were female and the mean age was 45 years. A total of 36.0% of patients had low BMD (28.1% in the total hip and 27.4% in the femoral neck), and 56.0% of patients had osteopenia (44.7% in the total hip and 53.8% in the femoral neck). A multivariate logistic regression showed that age, radiographic sacroiliitis and ASAS-HI were independently associated with low BMD in the total hip or femoral neck. Factors that were independently associated with osteopenia were Body Mass Index, disease duration, radiographic sacroiliitis and ASAS-HI. In conclusion, 36% of the patients with axSpA had low BMD in the total hip or femoral neck. A younger age and radiographic sacroiliitis were the most important factors associated with decreased BMD

Implementación de gestores del conocimiento en la escritura académica: alcance y límites

Panorámica sobre la elaboración, escritura y defensa de trabajos académicos con gestores bibliográficos, señalando su alcance, y sobre todo, sus límites

Accurate Identification of ALK Positive Lung Carcinoma Patients: Novel FDA-Cleared Automated Fluorescence In Situ Hybridization Scanning System and Ultrasensitive Immunohistochemistry

Background: Based on the excellent results of the clinical trials with ALK-inhibitors, the importance of accurately identifying ALK positive lung cancer has never been greater. However, there are increasing number of recent publications addressing discordances between FISH and IHC. The controversy is further fuelled by the different regulatory approvals. This situation prompted us to investigate two ALK IHC antibodies (using a novel ultrasensitive detection-amplification kit) and an automated ALK FISH scanning system (FDA-cleared) in a series of non-small cell lung cancer tumor samples. Methods: Forty-seven ALK FISH-positive and 56 ALK FISH-negative NSCLC samples were studied. All specimens were screened for ALK expression by two IHC antibodies (clone 5A4 from Novocastra and clone D5F3 from Ventana) and for ALK rearrangement by FISH (Vysis ALK FISH break-apart kit), which was automatically captured and scored by using Bioview's automated scanning system. Results: All positive cases with the IHC antibodies were FISH-positive. There was only one IHC-negative case with both antibodies which showed a FISH-positive result. The overall sensitivity and specificity of the IHC in comparison with FISH were 98% and 100%, respectively. Conclusions: The specificity of these ultrasensitive IHC assays may obviate the need for FISH confirmation in positive IHC cases. However, the likelihood of false negative IHC results strengthens the case for FISH testing, at least in some situation

Informe de gestión 2017-2020

Este documento reseña la gestión del Banco de la República entre 2017 y 2020, un período durante el cual el Banco logró consolidar una inflación baja y estable, con tasas de crecimiento cada vez más cercanas al potencial. A partir de marzo de 2020 se adoptaron políticas novedosas que lograron evitar una crisis profunda en medio de la pandemia del Coronavirus, un choque de enormes dimensiones para la humanidad. De otra parte, se tomaron medidas importantes tendientes a fortalecer la Administración del Banco, con un mayor control de los recursos financieros destinados a los distintos objetivos del Plan de Desarrollo. El Banco continúa siendo la institución estatal independiente que genera mayor confianza entre los colombianos por su transparencia, su ajuste a exigentes metas de resultados macroeconómicos y empresariales, y por el cumplimiento efectivo de las funciones de banca central y culturales encomendadas por la Constitución y la ley. RESUMEN EJECUTIVO La economía colombiana enfrentó en los últimos cuatro años algunos de los eventos que mayor impacto han tenido sobre su desempeño en más de un siglo. El precio internacional del petróleo cayó a menos de la tercera parte entre junio de 2014 y enero de 2016 y, nuevamente, entre septiembre de 2018 y abril de 2020; se presentaron frecuentes choques en el precio local de los alimentos, y la pandemia reciente ocasionó uno de los mayores desastres que ha padecido la humanidad en su historia. El Banco de la República (Banrep), sus directivos y empleados tuvieron que responder rápidamente a las nuevas circunstancias, un proceso que ha implicado grandes cambios en la forma como se han ejecutado y cumplido las funciones de la banca central y las del área cultural a cargo de la organización. De otra parte, el Plan Estratégico 2017-2021 sentó las bases para el nuevo programa de modernización del Banco, y en el presente Informe de gestión 2017-2020 se describen y analizan los retos enfrentados en el período y la forma en que se adaptó y modernizó la institución para hacerles frente. También se mencionan los principales desafíos que se avizoran hacia el futuro, con el fin de contribuir al diseño de los planes de la administración entrante. En este Resumen ejecutivo se presenta una síntesis del documento completo. En la sección II se hace un recuento de la situación económica de Colombia y el mundo en el cuatrienio reciente, y las medidas de política adoptadas por la Junta Directiva del Banco de la República (JDBR) para mantener la inflación baja y estable y contribuir a la recuperación del crecimiento de la economía. En la sección III se registran los avances y logros en los temas estratégicos del Plan Estratégico 2017-2021. En particular, se mencionan la política monetaria y de estabilidad financiera, la política cambiaria, la política de pagos, y otros temas relacionados con la eficiencia y eficacia en el Plan. La sección IV está dedicada a la gestión cultural, y en la sección V se describe la evolución de los temas de apoyo táctico para el logro de los objetivos del Plan: capital humano y cultura organizacional, tecnología e infraestructura; se incluye, además, un resumen de los avances en materia ambiental. En la sección VI se presentan los principales elementos de la respuesta del Banco ante la emergencia sanitaria del COVID-19. En la sección VII se describe el manejo de las reservas internacionales y se analizan el presupuesto y las utilidades del Banco. En la sección VIII se enuncian algunos desafíos futuros

GEODIVULGAR: Geología y Sociedad

Fac. de Ciencias GeológicasFALSEsubmitte

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Geodivulgar: Geología y Sociedad

Con el lema “Geología para todos” el proyecto Geodivulgar: Geología y Sociedad apuesta por la divulgación de la Geología a todo tipo de público, incidiendo en la importancia de realizar simultáneamente una acción de integración social entre estudiantes y profesores de centros universitarios, de enseñanza infantil, primaria, de educación especial y un acercamiento con público con diversidad funcional