Safety by design: dialogues between designers and builders using virtual reality

© 2015 The Author(s). Published by Taylor & Francis.Designers can contribute to enhancing the safety of construction work by considering how their decisions impact on both the physical environment in which construction workers operate and the means and methods they use. To do so, however, designers require knowledge about safety hazards on site and the opportunity to examine their designs early in projects. Through a set of studies virtual reality tools were used to examine the potential for collaborative dialogue between designers and builders to provide a forum for learning and proactive change of a design to make a project safer to build. In the tests, participants viewed proposed designs using virtual reality to examine various alternative design and construction scenarios. The study shows that consultation and dialogue with an experienced construction professional are highly beneficial for designers to appreciate the implications of designs on safety, and that designers are more willing to adapt design details than to change aesthetic aspects of their designs

Постать Тараса Шевченка в рецепції Ліни Костенко

У статті розглядається поетика творення Ліною Костенко образу Кобзаря крізь призму власного "я", через пережиті відчуття поета-шістдесятника, що своєю проекцією нагадують душевні терзання великого поета.В статье рассмотрена поэтика создания Линой Костенко образа Тараса Шевченко сквозь призму собственного "я", через пережитые ощущения поэта-шестидесятника, своей проекцией напоминающие душевные терзания великого поэта.The article deals with the problem of the poetics creation by Lina Kostenko Taras Shevchenko’ image through a prism her own mind, through sensations of the poet-sixtier, by the projection reminding sincere torments the great poet is considered

The broad spectrum of unbearable suffering in end of life cancer studied in dutch primary care

<p>Abstract</p> <p>Background</p> <p>Unbearable suffering most frequently is reported in end-of-life cancer patients in primary care. However, research seldom addresses unbearable suffering. The aim of this study was to comprehensively investigate the various aspects of unbearable suffering in end-of-life cancer patients cared for in primary care.</p> <p>Methods</p> <p>Forty four general practitioners recruited end-of-life cancer patients with an estimated life expectancy of half a year or shorter. The inclusion period was three years, follow-up lasted one additional year. Practices were monitored bimonthly to identify new cases. Unbearable aspects in five domains and overall unbearable suffering were quantitatively assessed (5-point scale) through patient interviews every two months with a comprehensive instrument. Scores of 4 (serious) or 5 (hardly can be worse) were defined unbearable. The last interviews before death were analyzed. Sources providing strength to bear suffering were identified through additional open-ended questions.</p> <p>Results</p> <p>Seventy six out of 148 patients (51%) requested to participate consented; the attrition rate was 8%, while 8% were alive at the end of follow-up. Sixty four patients were followed up until death; in 60 patients interviews were complete. Overall unbearable suffering occurred in 28%. A mean of 18 unbearable aspects was present in patients with serious (score 4) overall unbearable suffering. Overall, half of the unbearable aspects involved the domain of traditional medical symptoms. The most frequent unbearable aspects were weakness, general discomfort, tiredness, pain, loss of appetite and not sleeping well (25%-57%). The other half of the unbearable aspects involved the domains of function, personhood, environment, and nature and prognosis of disease. The most frequent unbearable aspects were impaired activities, feeling dependent, help needed with housekeeping, not being able to do important things, trouble accepting the situation, being bedridden and loss of control (27%-55%). The combination of love and support was the most frequent source (67%) providing strength to bear suffering.</p> <p>Conclusions</p> <p>Overall unbearable suffering occurred in one in every four end-of-life cancer patients. Half of the unbearable aspects involved medical symptoms, the other half concerned psychological, social and existential dimensions. Physicians need to comprehensively assess suffering and provide psychosocial interventions alongside physical symptom management.</p

Feasibility Study for Siting Anaerobic Digestion Facility at UMass Amherst Campus

Feasibility Study for possible AD facility at UMass Amherst: Includes Assessment of Proposed Site, Potential Organic Materials Quanitities and Characteristics, Conceptual Organics Processing Facilities, Project Pro Forma Financial Analysis and Conclusions

An impact assessment for urban stormwater use

The adoption of stormwater collection and use for a range of non-potable applications requires that the perceived risks, particularly those associated with public health, are addressed. Pollutant impacts have been assessed using E. coli and a scoring system on a scale of 0 to 5 to identify the magnitude of impacts and also the likelihood of exposure to stormwater during different applications. Combining these identifies that low or medium risks are generally predicted except for domestic car washing and occupational irrigation of edible raw food crops where the predicted high risk would necessitate the introduction of remedial action

ANALISIS YURIDIS PUTUSAN LEPAS DARI SEGALA TUNTUTAN (ONSLAG VAN VALLE RECHT VEVOLGING) DALAM TINDAK PIDANA PERSETUBUHAN TERHADAP ANAK (Putusan Nomor: 210/ Pid.A /2007/PN.Kbj)

Hukum pidana dalam hal pengaturan tentang kejahatan terhadap anak telah di atur sebagaimana di dalam Undang-Undang Nomor 23 Tahun 2003 tentang Perlindungan Anak. Terkait dengan kasus persetubuhan yang dilakukan terhadap anak dapat dilakukan mulai dari proses penyidikan sampai pada akhirnya proses pemidanaan di pengadilan juga sudahlah di atur dalam Undang-Undang Nomor 3 Tahun 1997 tentang Pengadilan Anak. Hal ini dikarenakan tindak pidana terhadap anak berbeda dengan tindak pidana umum (konvensional) yang di perbuat oleh orang dewasa. Meskipun mengenai proses penyidikan sampai nantinya di keluarkannya suatu putusan oleh hakim telah di atur secara jelas di dalam undang-undang tetapi masih terdapat kejanggalan di dalam suatu kasus kejahatan terhadap anak, khususnya kejahatan seksual terhadap anak. Terkait dengan suatu kejahatan terhadap anak yang di mana pelakunya merupakan orang yang belum dewasa juga di perlukan suatu pertimbangan hakim yang tegas terlebih apabila kasus tersebut terdapat juga unsur budaya daripada daerah /tempat tempat terjadinya kejahatan terhadap anak tersebut. Sehingga hakim harus jeli dan benar-benar memahami mengenai suatu unsur adat di dalam suatu daerah yang berada dalam kewenangan pengadilannya.Hal ini juga di peruntukkan kepada hakim untuk lebih menggali hukum yang tumbuh dan berkembang di dalam masyarakat sehingga nantinya hakim tidaklah hanya sebagai corongnya undang-undang saja

The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma

BACKGROUND: Despite high metastasis rates, adjuvant/neoadjuvant systemic therapy for localised soft tissue sarcoma (STS) is not used routinely. Progress requires tailoring therapy to features of tumour biology, which need exploration in well-documented cohorts. Hypoxia has been linked to metastasis in STS and is targetable. This study evaluated hypoxia prognostic markers in the phase III adjuvant radiotherapy VorteX trial. METHODS: Formalin-fixed paraffin-embedded tumour biopsies, fresh tumour/normal tissue and blood were collected before radiotherapy. Immunohistochemistry for HIF-1α, CAIX and GLUT1 was performed on tissue microarrays and assessed by two scorers (one pathologist). Prognostic analysis of disease-free survival (DFS) used Kaplan-Meier and Cox regression. RESULTS: Biobank and outcome data were available for 203 out of 216 randomised patients. High CAIX expression was associated with worse DFS (hazard ratio 2.28, 95% confidence interval: 1.44-3.59, P<0.001). Hypoxia-inducible factor-1α and GLUT1 were not prognostic. Carbonic anhydrase IX remained prognostic in multivariable analysis. CONCLUSIONS: The VorteX-Biobank contains tissue with linked outcome data and is an important resource for research. This study confirms hypoxia is linked to poor prognosis in STS and suggests that CAIX may be the best known marker. However, overlap between single marker positivity was poor and future work will develop an STS hypoxia gene signature to account for tumour heterogeneity

Cervical lymph node metastasis in adenoid cystic carcinoma of the larynx: a collective international review

Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to standardize a treatment protocol. One of the controversial points is the decision whether or not to perform an elective neck dissection on these patients. Because there is contradictory information about this issue, we have critically reviewed the literature from 1912 to 2015 on all reported cases of AdCC of the larynx in order to clarify this issue. During the most recent period of our review (1991-2015) with a more exact diagnosis of the tumor histology, 142 cases were observed of AdCC of the larynx, of which 91 patients had data pertaining to lymph node status. Eleven of the 91 patients (12.1%) had nodal metastasis and, based on this low proportion of patients, routine elective neck dissection is therefore not recommended

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, one year survival rates are only around ~45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease. This review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human osteosarcoma. Finally, the current position of canine osteosarcoma genetic research is discussed and areas for additional work within the canine population are identified