Rapport préliminaire sur les activités de la mission syro-française de Ras Shamra-Ougarit en 2007 et 2008 (67e et 68e campagnes)

Ce rapport présente les résultats préliminaires des travaux de terrain de la mission archéologique syro-française de Ras Shamra – Ougarit pour les campagnes de 2007 et 2008 qui se sont déroulées à Ras Shamra et sur plusieurs sites côtiers. Sur le tell de Ras Shamra, quatre opérations de fouilles ont été menées  : la poursuite du chantier du «  Rempart » et de celui de la «  Grand-rue », la reprise du dégagement du «  pont-barrage » sur le Nahr ed-Delbé et un nouveau chantier conjoint dans le secteur du «  Temple de Dagan ». Deux autres opérations ont commencé en 2008  : la prospection géomagnétique du tell et l’étude des techniques de taille de la pierre à Ougarit. Les travaux de la mission se sont portés également sur les sites côtiers du royaume d’Ougarit dans le cadre d’un nouveau programme conjoint visant à reconstituer l’évolution des paléo-environnements portuaires et la mobilité des paysages littoraux. La présentation des activités de terrain est complétée par une réflexion sur le plan de l’antique cité d’Ougarit et les premiers résultats de l’étude d’un atelier de travail du silex (Bronze récent final) mis au jour dans le chantier «  Grand-rue ».This report presents preliminary results from the Syrian-French archaeological excavations at Ras Shamra-Ugarit for the field seasons of 2007 and 2008, which took place at Ras Shamra and a number of coastal sites. At Ras Shamra tell, four excavations were undertaken : work continued at the sites of “Rempart” and “Grand-rue”, with further investigations of the “pont-barrage” on the Nahr ed-Delbe, in addition to a new joint site in the area of the “Temple de Dagan”. Two other projects began in 2008 : the geomagnetic survey of the tell and a study of the techniques of stone quarrying at Ugarit. The expedition’s work also extended to the coastal sites of the Kingdom of Ugarit within the framework of a new program looking to reconstruct the evolution of its harbours and mobility of the coastal landscapes. The presentation of the fieldwork activities is complemented by a piece looking at the plan of the ancient city of Ugarit and the first results of a study investigating a flint workshop (Late Bronze Age) unearthed at the “Grand-rue” site.خلاصة – يقدم هذا التقرير النتائج الأولية للبعثة الأثرية السورية-الفرنسية العاملة في موقع رأس شمرا- أوغاريت عن الأعمال تاميدانية في رأس شمرا خلال عامي 2007 و2008 وعدد من المواقع الساحلية. في موقع تل رأس شمرا، تمّ تنفيذ أربع عمليات حفر : إستكمال الحفريات في حقل « الأسوار» وحقل « الشارع الكبير»، ومتابعة أعمال الكشف على « الجسر-السد» على نهر الدلبة، بالإضافة الى المباشرة في تنفيذ تنقيب مشترك في حقل معبد « داغان». بالمقابل ثم المباشرة بتنفيذ عمليتين في أوغاريت خلال عام 2008 : عمليات مسح جيومغناطيسية للتل، ودراسة تقنية تتعلّق بطرق تقصيب وتشذيب أحجار البناء. تضمّنت أعمال البعثة أيضاً، العمل على المواقع الساحلية لمملكة أوغاريت وذلك ضمن إطار برنامج جديد مشترك يهدف إلى وضع تصوّر لتطوّر الظروف البيئية للمرافئ بالأضافة إلى تصوّر عام لكينونة الشريط الساحلي. إستكمال عرض الأعمال الميدانية بوضع تصوّر لمخطط المدينة القديمة لأوغاريت والنتائج الأولية لمشغل للأدوات الصوانية إكتشف في حقل « الشارع الكبير» يعود إلى عصر البرونز الحديث النهائي

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Vertical velocity and turbulence aspects during Mistral events as observed by UHF wind profilers

International audienceThe general purpose of this paper is to experimentally study mesoscale dynamical aspects of the Mistral in the coastal area located at the exit of the Rhône-valley. The Mistral is a northerly low-level flow blowing in southern France along the Rhône-valley axis, located between the French Alps and the Massif Central, towards the Mediterranean Sea. The experimental data are obtained by UHF wind profilers deployed during two major field campaigns, MAP (Mesoscale Alpine Program) in autumn 1999, and ESCOMPTE (Expérience sur Site pour COntraindre les Modèles de Pollution atmosphériques et de Transports d'Emission) in summer 2001. Thanks to the use of the time evolution of the vertical profile of the horizontal wind vector, recent works have shown that the dynamics of the Mistral is highly dependent on the season because of the occurrence of specific synoptic patterns. In addition, during summer, thermal forcing leads to a combination of sea breeze with Mistral and weaker Mistral due to the enhanced friction while, during autumn, absence of convective turbulence leads to substantial acceleration as low-level jets are generated in the stably stratified planetary boundary layer. At the exit of the Rhône valley, the gap flow dynamics dominates, whereas at the lee of the Alps, the dynamics is driven by the relative contribution of "flow around" and "flow over" mechanisms, upstream of the Alps. This paper analyses vertical velocity and turbulence, i.e. turbulent dissipation rate, with data obtained by the same UHF wind profilers during the same Mistral events. In autumn, the motions are found to be globally and significantly subsident, which is coherent for a dry, cold and stable flow approaching the sea, and the turbulence is found to be of pure dynamical origin (wind shears and mountain/lee wave breaking), which is coherent with non-convective situations. In summer, due to the ground heating and to the interactions with thermal circulation, the vertical motions are less pronounced and no longer have systematic subsident charateristics. In addition, those vertical motions are found to be much less developed during the nighttimes because of the stabilization of the nocturnal planetary boundary layer due to a ground cooling. The enhanced turbulent dissipation-rate values found at lower levels during the afternoons of weak Mistral cases are consistent with the installation of the summer convective boundary layer and show that, as expected in weaker Mistral events, the convection is the preponderant factor for the turbulence generation. On the other hand, for stronger cases, such a convective boundary layer installation is perturbed by the Mistral

Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal ă cord-derived microvascular endothelial cells

International audienceBackground: the heterogeneity of endothelial cell types underlies their remarkable ability to sub-specialize and provide specific requirements for a given vascular bed. Here, we compared rat microvascular endothelial cells (MECs) derived from the brain and spinal cord in both basal and inflammatory conditions.Methods: We used whole rat genome microarrays to compare, at different time points, basal and TNF-α-induced gene expression of rat MECs from in vitro models of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB). Validation at both messenger RNA (mRNA) and protein levels was performed on freshly extracted microvessels (MVs) from the brain and spinal cord (BMVs and SCMVs, respectively), as these were considered the closest in vivo tissues to cultured MECs.Results: Most of the genes encoding adhesion/tight junction molecules and known endothelial markers were similarly expressed in brain and spinal cord MECs (BMECs and SCMECs, respectively). However, one striking finding was the higher expression of several Hox genes, which encode transcription factors involved in positional identity. The differential expression of Hoxa9 and Hoxb7 at the mRNA levels as well as protein levels was confirmed in BMVs and SCMVs. Although the TNF-α response was in general higher in BMECs than in SCMECs at 12 h, the opposite was observed at 48 h. Furthermore, we found that expression of Tnfrsf1a and Tnfrsf1b encoding the TNF receptor super-family member 1a/TNFR1 and 1b/TNFR2, respectively, were constitutively higher in BMVs compared to SCMVs. However, only Tnfrsf1b was induced in SCMECs in response to TNF-α at 24 and 48 h.Conclusions: Our results support a role for HOX members in defining the positional identities of MECs in vivo. Our data also suggest that the delayed transcriptional activation upon TNF-α treatment in SCMECs results from the requirement of the TNF-induced expression of Tnfrsf1b. In contrast, its high basal expression in BMECs might be sufficient to confer an immediate and efficient TNF-α response

Additional file 1: Table S1. of Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells

TNF-α modulated expression of genes involved in the TNF-α signaling pathway in BMECs and SCMECs. (DOC 53 kb

Rapport préliminaire sur les activités de la mission archéologique syro-française de Ras Shamra−Ougarit en 2009 et 2010 (69e et 70e campagnes)

International audienceThis report presents preliminary results from the Syrian-French archaeological mission at Ras Shamra – Ugarit for the fields seasons of 2009 and 2010. At Ras Shamra tell, the study of the the Late Bronze Age city continued at several sites (“rempart”, “Grand-rue” with the excavations of a water well, “pont-barrage”, area east of the royal palace), with the study of the ashlar mansonry, in addition to a new site in the so-called “Maison de Yabninu”. Two others projects —soundings in the area of the so-called “Temple de Dagan” and a georadar survey— have helped to improve our knowledge of the city’s urban fabric. The expedition’s work also extended to the neighbouring site of Ras Ibn Hani in order to provide insights into the Holocene morphogenesis of the tombolo. Research on archaeological and epigraphic material was also undertaken in the museums of Damascus, Aleppo and Lattakia during these two campaigns.Ce rapport présente les résultats préliminaires des travaux de terrain de la mission archéologique syro-française de Ras Shamra – Ougarit qui se sont déroulés en 2009 et 2010. Sur le tell de Ras Shamra, l’étude de la ville d’Ougarit au Bronze récent s’est poursuivie sur plusieurs chantiers (« Rempart » et « Grand-rue » avec la fouille d’un puits en eau, « pont-barrage », étude du quartier à l’est du Palais royal), au travers de l’étude des techniques de construction (taille de la pierre), et par une nouvelle opération portant sur la Maison dite « de Yabninou ». Deux opérations (sondage dans le secteur du temple dit « de Dagan » et prospection géoradar) ont privilégié l’approche diachronique afin de mieux comprendre l’évolution urbanistique de la cité. Les travaux géoarchéologiques de la mission ont porté également sur le site voisin de Ras Ibn Hani afin de reconnaître l’évolution géomorphologique du tombolo au cours de l’Holocène. Au cours de ces deux campagnes, de nombreuses études portant sur le matériel archéologique et épigraphique des fouilles anciennes et récentes se sont par ailleurs poursuivies dans les musées de Damas, d’Alep et de Lattaquié