964 research outputs found
The persistence of a proxy for cooking emissions in megacities: a kinetic study of the ozonolysis of self-assembled films by simultaneous small and wide angle X-ray scattering (SAXS/WAXS) and Raman microscopy
Bound Pairs: Direct Evidence for Long-range Attraction between Like-Charged Colloids
We report observations of stable bound pairs in very dilute deionized aqueous
suspensions of highly charged polystyrene colloidal particles, with monovalent
counterions, using a confocal laser scanning microscope. Through an analysis of
several thousands of time series of confocal images recorded deep inside the
bulk suspension, we find that the measured pair-potential, U(r) has a
long-range attractive component with well depths larger than the thermal
energy. These observations provide a direct and unequivocal evidence for the
existence of long-range attraction in U(r) of like-charged colloidal particles.Comment: 8 pages, 4 figures, submitted to Phys. Rev. Let
Elongation rate and average length of amyloid fibrils in solution using isotope-labelled small-angle neutron scattering.
Funder: Boehringer Ingelheim FondsFunder: University of BathWe demonstrate a solution method that allows both elongation rate and average fibril length of assembling amyloid fibrils to be estimated. The approach involves acquisition of real-time neutron scattering data during the initial stages of seeded growth, using contrast matched buffer to make the seeds effectively invisible to neutrons. As deuterated monomers add on to the seeds, the labelled growing ends give rise to scattering patterns that we model as cylinders whose increase in length with time gives an elongation rate. In addition, the absolute intensity of the signal can be used to determine the number of growing ends per unit volume, which in turn provides an estimate of seed length. The number of ends did not change significantly during elongation, demonstrating that any spontaneous or secondary nucleation was not significant compared with growth on the ends of pre-existing fibrils, and in addition providing a method of internal validation for the technique. Our experiments on initial growth of alpha synuclein fibrils using 1.2 mg ml-1 seeds in 2.5 mg ml-1 deuterated monomer at room temperature gave an elongation rate of 6.3 ± 0.5 Å min-1, and an average seed length estimate of 4.2 ± 1.3 μm
Active colloids in complex fluids
We review recent work on active colloids or swimmers, such as self-propelled
microorganisms, phoretic colloidal particles, and artificial micro-robotic
systems, moving in fluid-like environments. These environments can be
water-like and Newtonian but can frequently contain macromolecules, flexible
polymers, soft cells, or hard particles, which impart complex, nonlinear
rheological features to the fluid. While significant progress has been made on
understanding how active colloids move and interact in Newtonian fluids, little
is known on how active colloids behave in complex and non-Newtonian fluids. An
emerging literature is starting to show how fluid rheology can dramatically
change the gaits and speeds of individual swimmers. Simultaneously, a moving
swimmer induces time dependent, three dimensional fluid flows, that can modify
the medium (fluid) rheological properties. This two-way, non-linear coupling at
microscopic scales has profound implications at meso- and macro-scales: steady
state suspension properties, emergent collective behavior, and transport of
passive tracer particles. Recent exciting theoretical results and current
debate on quantifying these complex active fluids highlight the need for
conceptually simple experiments to guide our understanding.Comment: 6 figure
Apparent wave function collapse caused by scattering
Some experimental implications of the recent progress on wave function
collapse are calculated. Exact results are derived for the center-of-mass wave
function collapse caused by random scatterings and applied to a range of
specific examples. The results show that recently proposed experiments to
measure the GRW effect are likely to fail, since the effect of naturally
occurring scatterings is of the same form as the GRW effect but generally much
stronger. The same goes for attempts to measure the collapse caused by quantum
gravity as suggested by Hawking and others. The results also indicate that
macroscopic systems tend to be found in states with (Delta-x)(Delta-p) =
hbar/sqrt(2), but microscopic systems in highly tiltedly squeezed states with
(Delta-x)(Delta-p) >> hbar.Comment: Final published version. 20 pages, Plain TeX, no figures. Online at
http://astro.berkeley.edu/~max/collapse.html (faster from the US), from
http://www.mpa-garching.mpg.de/~max/collapse.html (faster from Europe) or
from [email protected]
Exploring the nanostructures accessible to an organic surfactant atmospheric aerosol proxy
The composition of atmospheric aerosols varies with time, season, location, and environment. This affects key aerosol properties such as hygroscopicity and reactivity, influencing the aerosol’s impact on the climate and air quality. The organic fraction of atmospheric aerosol emissions often contains surfactant material, such as fatty acids. These molecules are known to form three-dimensional nanostructures in contact with water. Different nanostructures have marked differences in viscosity and diffusivity that are properties whose understanding is essential when considering an aerosol’s atmospheric impact. We have explored a range of nanostructures accessible to the organic surfactant oleic acid (commonly found in cooking emissions), simulating variation that is likely to happen in the atmosphere. This was achieved by changing the amount of water, aqueous phase salinity and by addition of other commonly coemitted compounds: sugars and stearic acid (the saturated analogue of oleic acid). The nanostructure was observed by both synchrotron and laboratory small/wide angle X-ray scattering (SAXS/WAXS) and found to be sensitive to the proxy composition. Additionally, the spacing between repeat units in these nanostructures was water content dependent (i.e., an increase from 41 to 54 Å in inverse hexagonal phase d-spacing when increasing the water content from 30 to 50 wt %), suggesting incorporation of water within the nanostructure. A significant decrease in mixture viscosity was also observed with increasing water content from ∼104 to ∼102 Pa s when increasing the water content from 30 to 60 wt %. Time-resolved SAXS experiments on levitated droplets of this proxy confirm the phase changes observed in bulk phase mixtures and demonstrate that coexistent nanostructures can form in droplets. Aerosol compositional and subsequent nanostructural changes could affect aerosol processes, leading to an impact on the climate and urban air pollution
Does the universe in fact contain almost no information?
At first sight, an accurate description of the state of the universe appears
to require a mind-bogglingly large and perhaps even infinite amount of
information, even if we restrict our attention to a small subsystem such as a
rabbit. In this paper, it is suggested that most of this information is merely
apparent, as seen from our subjective viewpoints, and that the algorithmic
information content of the universe as a whole is close to zero. It is argued
that if the Schr\"odinger equation is universally valid, then decoherence
together with the standard chaotic behavior of certain non-linear systems will
make the universe appear extremely complex to any self-aware subsets that
happen to inhabit it now, even if it was in a quite simple state shortly after
the big bang. For instance, gravitational instability would amplify the
microscopic primordial density fluctuations that are required by the Heisenberg
uncertainty principle into quite macroscopic inhomogeneities, forcing the
current wavefunction of the universe to contain such Byzantine superpositions
as our planet being in many macroscopically different places at once. Since
decoherence bars us from experiencing more than one macroscopic reality, we
would see seemingly complex constellations of stars etc, even if the initial
wavefunction of the universe was perfectly homogeneous and isotropic.Comment: 17 pages, LATeX, no figures. Online with refs at
http://astro.berkeley.edu/~max/nihilo.html (faster from the US), from
http://www.mpa-garching.mpg.de/~max/nihilo.html (faster from Europe) or from
[email protected]
Opportunities for organoids as new models of aging.
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use. More importantly, they may not reflect directly on the process of aging in people. Human cell culture provides an alternative, but many functional signs of aging occur at the level of tissues rather than cells and are therefore not readily apparent in traditional cell culture models. Organoids have the potential to effectively balance between the strengths and weaknesses of traditional models of aging. They have sufficient complexity to capture relevant signs of aging at the molecular, cellular, and tissue levels, while presenting an experimentally tractable alternative to animal studies. Organoid systems have been developed to model many human tissues and diseases. Here we provide a perspective on the potential for organoids to serve as models for aging and describe how current organoid techniques could be applied to aging research
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Measurements of traffic-dominated pollutant emissions in a Chinese megacity
Direct measurements of NOx, CO and aromatic volatile organic compound (VOC) (benzene, toluene, C2-benzenes and C3-benzenes) flux were made for a central area of Beijing using the eddy-covariance technique. Measurements were made during two intensive field campaigns in central Beijing as part of the Air Pollution and Human Health (APHH) project, the first in November–December 2016 and the second during May–June 2017, to contrast wintertime and summertime emission rates. There was little difference in the magnitude of NOx flux between the two seasons (mean NOx flux was 4.41 mg m−2 h−1 in the winter compared to 3.55 mg m−2 h−1in the summer). CO showed greater seasonal variation, with mean CO flux in the winter campaign (34.7 mg m−2 h−1) being over twice that of the summer campaign (15.2 mg m−2 h−1). Larger emissions of aromatic VOCs in summer were attributed to increased evaporation due to higher temperatures. The largest fluxes in NOx and CO generally occurred during the morning and evening rush hour periods, indicating a major traffic source with high midday emissions of CO, indicating an additional influence from cooking fuel. Measured NOx and CO fluxes were then compared to the MEIC 2013 emissions inventory, which was found to significantly overestimate emissions for this region,providing evidence that proxy-based emissions inventories have positive biases in urban centres. This first set of pollutant fluxes measured in Beijing provides an important benchmark of emissions from the city which can help to inform and evaluate current emissions inventories
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