Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Enquête sur la composition des armoires à pharmacie familiales

TOULOUSE3-BU Santé-Centrale (315552105) / SudocSudocFranceF

Composition des armoires à pharmacie familiales : échantillon de 207 foyers de la région Aquitaine

La France figure au 1er rang européen de la consommation des médicaments, il n’est pas envisageable de concevoir un foyer sans armoire à pharmacie. Cependant, il n’existe que très peu de données sur ce sujet. L’objectif de notre étude a été d’étudier la composition des armoires à pharmacie dans les foyers. Sur le 1er semestre 2010, un questionnaire d’investigation sur la composition des armoires à pharmacie a été distribué à tous les patients se rendant dans une pharmacie des Pyrénées-Atlantiques. Sur 207 questionnaires exploitables, l’armoire à pharmacie contenait en moyenne 12,1  ±  12,1 noms de spécialités différents avec 19,8  ±  17,9 conditionnements différents (le plus fréquemment : classe V : divers et classe A : système digestif et métabolisme) et en moyenne 5,6  ±  7,5 conditionnements sont périmés (28,4 % du contenu). L’armoire à pharmacie comporte une quantité importante de médicaments, ceci encourageant la démarche et le rôle d’éducation thérapeutique du pharmacien et du médecin traitant

Comportement d'une collection de porte-greffes de vigne en présence d'une population de nématodes (<em>Meloidogyne sp.</em>) originaire du Sud-Ouest de la France

La présente étude vise à compléter les connaissances actuelles sur la résistance des porte-greffes de la vigne aux populations de Meloidogyne autochtones. La population utilisée, qui appartient au complexe M. incognita-arenaria semble nettement plus agressive que ies populations de M. arenaria originaire du Languedoc, en particulier vis-à-vis de Vitis Rupestris et de certains de ses hybrides. Toutefois, le classement relatif des porte-greffes ne semble pas profondément modifié, notamment en ce qui concerne les plus résistants. +++ The present study aims at completing the knowledge available at present concerning the resistance of vine stocks to the populations of autochthonous Meloidogyne. The population used, which belongs to the M. incognita-arenaria complex seems distinctly more aggressive than the populations of M. arenaria originating from the Languedoc, in particular in regard to the Rupestris and certain of its hybrids. Nevertheless, the relative classification of stocks does not seem to be changed greatly, notably in so far as the most resistant are concerned

Les vins de Bordeaux. Itinéraires de la qualité (Tome 2)

À la suite du premier volume Vins et vignobles. Les itinéraires de la qualité (Antiquité – XXIe siècle), paru en 2014, où des chercheurs en sciences sociales, historiens, géographes, sociologues…, en collaboration avec des œnologues, des agronomes et d’autres spécialistes des sciences du vivant, remettent en cause l’affirmation selon laquelle les vins qualitatifs étaient nés au XVIIIe siècle, une équipe pluridisciplinaire de l’Institut des sciences de la vigne et du vin de Bordeaux signe sur la qualité un second volume, Les vins de Bordeaux. Les itinéraires de la qualité. Dans celui-ci, les auteurs confirment la longue durée de l’histoire du vignoble de Bordeaux où la montée en qualité apparaît comme une construction historique à laquelle prennent part l’évolution des savoirs, celle des pratiques de vinification mais aussi celle du monde du commerce et de la critique. Leur cheminement conduit à la mise en avant de l’" âme du bordeaux " qui au-delà de l’origine, au-delà des qualités organoleptiques, façonne la typicité d’un vin de Bordeaux au sein d’un marché où les vins sont de plus en plus sans défauts. Le bordeaux apparaît alors comme un vin d’assemblage à cause de la diversité des sols de chaque cru, à cause de la variabilité du climat, un vin pour lequel le vigneron est au service du terroir, à l’opposé de beaucoup d’autres vins du Monde, principalement des vins technologiques s’émancipant de son origine pour répondre à un goût, souvent boisé, qui serait celui préféré par les nouveaux consommateurs

Structure of sediment-associated bacterial communities along a hydrocarbon contamination gradient in coastal sediment

The bacterial diversity of a chronically oil-polluted retention basin sediment located in the Berre lagoon (Etang-de-Berre, France) was investigated. This study combines chemical and molecular approaches in order to define how the in situ petroleum hydrocarbon contamination level affects the bacterial community structure of a subsurface sediment. Hydrocarbon content analysis clearly revealed a gradient of hydrocarbon contamination in both the water and the sediment following the basin periphery from the pollution input to the lagoon water. The nC17 and pristane concentrations suggested alkane biodegradation in the sediments. These results, combined with those of terminal-restriction fragment length polymorphism analysis of the 16S rRNA genes, indicated that bacterial community structure was obviously associated with the gradient of oil contamination. The analysis of bacterial community composition revealed dominance of bacteria related to the Proteobacteria phylum (Gamma-, Delta-, Alpha-, Epsilon- and Betaproteobacteria), Bacteroidetes and Verrucomicrobium groups and Spirochaetes, Actinobacteria and Cyanobacteria phyla. The adaptation of the bacterial community to oil contamination was not characterized by dominance of known oildegrading bacteria, because a predominance of populations associated to the sulphur cycle was observed. The input station presented particular bacterial community composition associated with a low oil concentration in the sediment, indicating the adaptation of this community to the oil contamination

Parentage of grapevine rootstock 'Fercal' finally elucidated

International audienceUsing a set of 20 microsatellite markers, 'B.C. n degrees 1B' (mother) and '31 Richter' (father) were demonstrated to be the true parents of 'Fercal' rootstock. '333 Ecole de Montpellier' was definitively excluded as the putative father. 'B.C. n degrees 1A' and 'B.C. n degrees 1B' were shown to be distinct genotypes. 'Ugni blanc', and not 'Colombard', was discovered to be the Pais vinifera father of 'B.C. n degrees 1B'

Etude du déterminisme génétique de diverses sources de résistance de la vigne au mildiou

National audienc