Synthesis of Some Biologically Effective 5-substituted-2-(p-tert-butylphenyl)Benzoxazoles

Synthesis of Some Biologically Effective 5-substituted-2-(p-tert-butylphenyl)BenzoxazolesMeryem Taşcı1, &nbsp;&Ouml;zlem Temiz-Arpacı2, 1 Erciyes University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Kayseri, Turkey2Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandogan, Ankara, Turkey.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Benzoxazoles, structural isosteres of natural nucleotides that can interact with biopolymers, constitute an important class of heterocyclic compounds [1,2]. So that benzoxazoles showed potential antitumor, antiviral and antibiotic activities as the new topoisomerase I poisons, HIV-1 reverse transcriptase inhibitors and/or potent DNA gyrase inhibitors. [3-5].&nbsp;&nbsp;&nbsp;&nbsp; In this study, firstly, 5-Amino-2-(p-tert-butylphenyl)-benzoxazole (1) was synthesized by heating&nbsp; 2,4-diaminophenol with p-tert-butyl benzoic acid in polyphosphoric acid (PPA). &nbsp;&nbsp;Then&nbsp; compound 2 was obtained by treating a solution of 2-chloroacetylchloride&nbsp; with 5-amino-2-(p-tert-butylphenyl)-benzoxazole. Finally, compound 2 was treated by some 4-(p-substituted piperazine/ piperidine derivatives and morpholine. All the results compounds (3-12) (Figure) were prepared as original products (except compound 12) with the hope of discovering new effective antimicrobial agents.&nbsp;&nbsp;&nbsp;&nbsp; The 1H-NMR, 13C NMR and mass spectra and elemental analysis results agree with those of the proposed structures.&nbsp; &nbsp; &nbsp; REFERENCESTemiz-Arpaci O., Eylem Cifcioglu Goztepe B., Kaynak-Onurdag F., Ozgen S., Senol F.S., and Erdogan Orhan I . (2013), Synthesis and different biological activities of novel benzoxazoles. Acta Biol. Hung. 64, 249 - 261.Arisoy M., Temiz-Arpaci O., Kaynak-Onurdag F., and Ozgen S. (2012), Synthesis and Antimicrobial activity of novel benzoxazoles. Z. Naturforsch. 67c, 466 - 472.&nbsp;Akbay, A.; Oren, I.; Temiz-Arpaci, O.; Aki-Sener, E.; Yalcin, I. Arzneim. Forsch. 2003, 53(4), 266 -271.&nbsp;Temiz-Arpaci, O.; Tekiner-Gulbas, B.; Yildiz, I.; Aki-Sener, E.; Yalcin,I. Bioorg. Med. Chem. 2005, 13, 6354-6359.Pinar, A.; Yurdakul, P.; Yildiz, I.; Temiz-Arpaci, O.; Acan, N.L.; Aki-Sener, E.; Yalcin I. Biochem. Biophy. Res. Comm. 2004, 317, 670-674.&nbsp;Correspondence:&nbsp;&nbsp;&nbsp; [email protected] &nbsp;&nbsp;&nbsp;/&nbsp;&nbsp;&nbsp; [email protected]</p

Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas.

Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT

Prevalence and predictors of gestational diabetes mellitus: a nationwide multicentre prospective study

Cetinkaya, Esra/0000-0003-2415-1236; Taskiran, Bengur/0000-0003-4842-450X; MELEKOGLU, RAUF/0000-0001-7113-6691; pekkolay, zafer/0000-0002-5323-2257; Ozer, Alev/0000-0002-0934-0226; kilinc, faruk/0000-0002-0198-2558; Aygun, Elif Ganime/0000-0003-3737-7250; KARAKILIC, ERSEN/0000-0003-3590-2656; Aydin, Hasan/0000-0003-4246-0681WOS: 000457530200011PubMed: 30402933Aim Prevalence rates of gestational diabetes mellitus (GDM) show considerable variation among different countries and regions of the world. The primary aim of this study was to determine the nationwide prevalence and predictors of GDM in Turkey. Methods We conducted prospective nationwide screening among pregnant women. Between August 2016 and November 2017, a total of 2643 pregnant women from 51 centres in 12 different regions were enrolled. A two-step screening method and Carpenter and Coustan criteria were used in the diagnosis of GDM. Clinical and biochemical data were obtained using electronic database software. Results The national prevalence of GDM was found to be 16.2% [95% confidence intervals (CI) 15.0% to 17.4%] without a significant difference between urban and rural regions. Women with GDM were older (mean age: 32 +/- 5 vs. 28 +/- 5 years, P < 0.001) and heavier (mean BMI: 27.2 +/- 5.1 vs. 24.7 +/- 4.7 kg/m(2), P < 0.001) than their counterparts without GDM. The prevalence of GDM tended to increase with age (< 25 years, 6.9%; 26-35 years, 15.6%; and 36-45 years, 32.7%; P < 0.001). Maternal age, maternal BMI, history of previous GDM and family history of diabetes mellitus were independent predictors of developing GDM (P < 0.05 for all). Low-risk women (age < 25 years, BMI < 25 kg/m(2), no family history of diabetes) comprised 10.7% of the total population and the prevalence of GDM in these women was 4.5% (95% CI 2.4% to 7.8%). Conclusion The results of this nationwide study indicate that GDM is very common, affecting one in seven pregnancies in Turkey. Implementation of international guidelines on screening and management of this public health problem is required