Depression and Empathy Predict Emotion-Modulated Startle Reactivity

Research supports varied patterns of emotion-modulated startle (EMS) reactivity among depressed individuals. The purpose of this study was to examine whether these varied patterns can be explained by depression, empathic tendencies, and emotional stimuli. The EMS paradigm is a well-validated measure of emotion-modulated reactivity in which the magnitude of startle reflexes in reaction to acoustic stimuli are recorded while participants view pleasant, neutral, and negative images (Lang, Bradley, & Cuthbert, 1990). Young adults (N = 120; Mage = 19.54, SD = 1.41; 75% female) completed self-report rating scales of depression symptoms and cognitive and affective empathic tendencies and the EMS paradigm. Individuals with low depression, regardless of their cognitive (hp2 = .44 and .47) and affective empathic tendencies (hp2 = .49 and .36), and individuals with high depression and high cognitive and affective empathic tendencies (hp2 = .23, .46, respectively) exhibited the typical linear EMS reactivity pattern of increasing startle reflex magnitude from pleasant to neutral to unpleasant images. In contrast, individuals with high depression along with low cognitive and affective empathic tendencies exhibited blunted EMS reactivity patterns (hp2 = .000, .04, respectively). These findings indicate blunted EMS reactivity patterns only in depressed individuals who have low cognitive and affective empathic tendencies and are likely disengaged from emotional stimuli, thus suggesting variability among depressed individuals in motivational states that prime or inhibit the startle reflex

Quadratic associations between empathy and depression and the moderating influence of dysregulation

Empathic tendencies have been associated with interpersonal and psychological benefits, but empathy at extreme levels or in combination with certain personal characteristics may contribute to risk for depression. This study tested the moderating role of cognitive emotion regulation in depression’s association with empathy using nonlinear models. Young adults (N=304; 77% female; M=19 years) completed measures of cognitive emotion regulation strategies, depression, and affective and cognitive empathy. Individuals with good regulation had low levels of depression overall and their depression symptoms were lowest when levels of affective empathy were average. Individuals with poor regulation had high levels of depression overall, particularly when levels of empathy were moderate to high. Extremely high and low levels of cognitive empathy were associated with elevated depression, and this association was not moderated by regulation. These findings suggest tendencies to respond empathically to others’ needs is neither an adaptive nor maladaptive characteristic but rather moderate empathy, particularly in the context of good regulation, may offer the greatest protection against depression

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Examining Self-Concealment within the Framework of Psychological Inflexibility and Mindfulness: A Preliminary Cross-Sectional Investigation

Although self-concealment has been a central topic in the field of personality and applied psychologies, it remains somewhat unclear how it should be conceptualized. The present study investigated self-concealment within the framework of psychological inflexibility and mindfulness, two major emotion/behavior regulation processes integrated into contemporary cognitive behavioral models of behavioral health. One-thousand sixty college undergraduates (77 % female; n = 816) completed a web-based survey that included the measures of interest. Results revealed that psychological inflexibility was positively and uniquely associated with self-concealment. The association between mindfulness and self-concealment was moderated by gender; higher levels of self-concealment predicted lower levels of mindfulness for women only and were associated with sexual-minority men, but self-concealment did not vary for women as a function of sexual orientation status. Additional results and future directions are also discussed

Examination of Adult Spinal Deformity Patients Undergoing Surgery with Implanted Spinal Cord Stimulators and Intrathecal Pumps.

STUDY DESIGN: Retrospective cohort study of a prospectively collected multi-center database of adult spinal deformity (ASD) patients. OBJECTIVE: We hypothesized that patients undergoing ASD surgery with and without previous SCS/ITP would exhibit increased complication rates but comparable improvement in HRQOL. SUMMARY OF BACKGROUND DATA: ASD patients sometimes seek pain management with spinal cord stimulators (SCS) or intrathecal medication pumps (ITP) prior to spinal deformity correction. Few studies have examined outcomes in this patient population. METHODS: Patients undergoing ASD surgery and eligible for 2-year follow-up were included. Pre-operative radiographs were reviewed for the presence of SCS/ITP. Outcomes included complications, ODI, SF-36 MCS, and SRS-22r. Propensity score matching was utilized. RESULTS: In total, out of 1,034 eligible ASD patients, a propensity score-matched cohort of 60 patients (30 with SCS/ITP, 30 controls) was developed. SCS/ITP were removed intra-operatively in most patients (56.7%, n = 17). The overall complication rate was 80.0% versus 76.7% for SCS/ITP versus control (p \u3e 0.2), with similarly non-significant differences for intraoperative and infection complications (all p \u3e 0.2). ODI was significantly higher among patients with SCS/ITP at baseline (59.2 versus 47.6, p = 0.0057) and at 2-year follow-up (44.4 versus 27.7, p = 0.0295). The magnitude of improvement, however, did not significantly differ (p = 0.45). Similar results were observed for SRS-22r pain domain. Satisfaction did not differ between groups at either baseline or follow-up (p \u3e 0.2). No significant difference was observed in the proportion of patients with SCS/ITP versus control reaching MCID in ODI (47.6% versus 60.9%, p = 0.38). Narcotic usage was more common among patients with SCS/ITP at both baseline and follow-up (p \u3c 0.05). CONCLUSIONS: ASD patients undergoing surgery with SCS/ITP exhibited worse preoperative and post-operative ODI and SRS-22r pain domain; however, the mean improvement in outcome scores was not significantly different from patients without stimulators or pumps. No significant differences in complications were observed between patients with versus without SCS/ITP.Level of Evidence: 3