10 THz Ultrafast Function Generator - generation of rectangular and triangular pulse trains-

We report the synthesis of arbitrary optical waveforms by manipulating the spectral phases of Raman sidebands with a wide frequency spacing line-by-line. Trains of rectangular and triangular pulses are stably produced at an ultrahigh repetition rate of 10.6229 THz, reminiscent of an ultrafast function generator.Comment: 7 Pages, 5 Figure

Students’ understanding about clinical research and their willingness to participate in clinical trials

Drug development is a tedious process involving a huge amount of time and money. Clinical trials are the important part of the drug development process. In clinical trials, subject recruitment is challenging especially when recruiting the Generation Y (millennial) population group. This might be generational or due to few barriers. In the present research, in-class surveys were done in the College of Health and Human Services and the College of Business at Eastern Michigan University to determine whether an educational intervention impacts the willingness of Generation Y to participate in clinical research. This interventional group (active group or exposure group) was compared to a placebo group (without any educational intervention). In both treatment groups, the number of students who were willing to participate in clinical trials was \u3e 90%. This clearly indicates that the intervention used did not work, or it simply means that the students are willing to participate in clinical trials. Between Generation Y (n = 114) and the 35 years or older group (n = 2), far more of Generation Y, almost 98.3%, indicated that they were willing to participate in clinical research. This trend might be different if the sample size were similar. When asked “How knowledgeable are you about clinical research?” participants with science backgrounds clearly indicated more knowledge than non-science professions. Three quarters of participants said they have complete knowledge about clinical research, but upon further analysis it was seen that they answered incorrectly when asked what clinical research is. Therefore, further research is needed on these parameters with a better exposure of the treatment group and with equal sample size in both the comparing groups, since the number of participants older than 35 years in the present study was too limited to make any reliable conclusions

RASPBERRY PI BASED WIRELESS LOAD CONTROL AND MONITORING USING INTERACTIVE VOICE RESPONSE SYSTEM

With the current advancement in wireless networks and various technologies implemented for automation, more innovative and improved ideas are developed to build automation systems facilitating remote controlling and monitoring of devices. In this paper, a GSM based wireless home automation system is proposed and deployed which executes its function of controlling and monitoring appliances remotely. It is compliant, cost effective, low power consumption; highly efficient GSM (Global System for Mobile Communication) based wireless home system. The Interactive Voice Response System (IVRS) is improvised to embellish the system’s security and ease of operation. With the help of this system the user can access his home appliances from anywhere and at any time as per the requirement aiding convenience. The system permits the user direct devices through his mobile by sending voice commands using IVRS system. It also enables the user to monitor the status of loads with SMS update. A detailed system analysis is carried out and presented in this paper

Synergistic Effects of Cilostazol and Probucol on ER Stress-Induced Hepatic Steatosis via Heme Oxygenase-1-Dependent Activation of Mitochondrial Biogenesis

The selective type-3 phosphodiesterase inhibitor cilostazol and the antihyperlipidemic agent probucol have antioxidative, anti-inflammatory, and antiatherogenic properties. Moreover, cilostazol and probucol can regulate mitochondrial biogenesis. However, the combinatorial effect of cilostazol and probucol on mitochondrial biogenesis remains unknown. Endoplasmic reticulum (ER) stress is a well-known causative factor of nonalcoholic fatty liver disease (NAFLD) which can impair mitochondrial function in hepatocytes. Here, we investigated the synergistic effects of cilostazol and probucol on mitochondrial biogenesis and ER stress-induced hepatic steatosis. A synergistic effect of cilostazol and probucol on HO-1 and mitochondrial biogenesis gene expression was found in human hepatocellular carcinoma cells (HepG2) and murine primary hepatocytes. Furthermore, in an animal model of ER stress involving tunicamycin, combinatorial treatment with cilostazol and probucol significantly increased the expression of HO-1 and mitochondrial biogenesis-related genes and proteins, whereas it downregulated serum ALT, eIF2 phosphorylation, and CHOP expression, as well as the lipogenesis-related genes SREBP-1c and FAS. Based on these results, we conclude that cilostazol and probucol exhibit a synergistic effect on the activation of mitochondrial biogenesis via upregulation of HO-1, which confers protection against ER stress-induced hepatic steatosis

Hybrid additive manufacturing of 3D electronic systems

A novel hybrid additive manufacturing (AM) technology combining digital light projection (DLP) stereolithography (SL) with 3D micro-dispensing alongside conventional surface mount packaging is presented in this work. This technology overcomes the inherent limitations of individual AM processes and integrates seamlessly with conventional packaging processes to enable the deposition of multiple materials. This facilitates the creation of bespoke end-use products with complex 3D geometry and multi-layer embedded electronic systems. Through a combination of four-point probe measurement and non-contact focus variation microscopy, it was identified that there was no obvious adverse effect of DLP SL embedding process on the electrical conductivity of printed conductors. The resistivity maintained to be less than 4  ×  10−4 Ω centerdot cm before and after DLP SL embedding when cured at 100 °C for 1 h. The mechanical strength of SL specimens with thick polymerized layers was also identified through tensile testing. It was found that the polymerization thickness should be minimised (less than 2 mm) to maximise the bonding strength. As a demonstrator a polymer pyramid with embedded triple-layer 555 LED blinking circuitry was successfully fabricated to prove the technical viability

Hybrid inorganic-organic capsules for efficient intracellular delivery of novel siRNAs against influenza A (H1N1) virus infection

This work was supported by ARUK project grant 21210 ‘Sustained and Controllable Local Delivery of Anti-inflammatory Therapeutics with Nanoengineered Microcapsules’. The work was also supported in part by Russian Foundation of Basic Research grants No. 16-33-50153 mol_nr, No. 16-33-00966 mol_a, Russian Science Foundation grant No. 15-15-00170 and Russian Governmental Program ‘‘Nauka’’, No. 1.1658.2016, 4002