171 research outputs found
Semicosimplicial DGLAs in deformation theory
We identify Cech cocycles in nonabelian (formal) group cohomology with
Maurer-Cartan elements in a suitable L-infinity algebra. Applications to
deformation theory are described.Comment: Largely rewritten. Abstract modified. 15 pages, Latex, uses xy-pi
Derived coisotropic structures II: stacks and quantization
We extend results about -shifted coisotropic structures from part I of
this work to the setting of derived Artin stacks. We show that an intersection
of coisotropic morphisms carries a Poisson structure of shift one less. We also
compare non-degenerate shifted coisotropic structures and shifted Lagrangian
structures and show that there is a natural equivalence between the two spaces
in agreement with the classical result. Finally, we define quantizations of
-shifted coisotropic structures and show that they exist for .Comment: 45 pages. Contains the second half of arXiv:1608.01482v1 with new
material adde
Deformation quantisation for unshifted symplectic structures on derived Artin stacks
We prove that every -shifted symplectic structure on a derived Artin
-stack admits a curved deformation quantisation. The classical
method of quantising smooth varieties via quantisations of affine space does
not apply in this setting, so we develop a new approach. We construct a map
from DQ algebroid quantisations of unshifted symplectic structures on a derived
Artin -stack to power series in de Rham cohomology, depending only on a
choice of Drinfeld associator. This gives an equivalence between even power
series and certain involutive quantisations, which yield anti-involutive curved
deformations of the dg category of perfect complexes. In
particular, there is a canonical quantisation associated to every symplectic
structure on such a stack, which agrees for smooth varieties with the
Kontsevich--Tamarkin quantisation for even associators.Comment: 27pp.; v2 Propositions 1.23 and 3.10 added; v3 several small
additions; v4 several changes following referee's comments, to appear in
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The Unintended Consequences of a European Neighbourhood Policy without Russia
After Russia’s retreat from the European Neighbourhood Policy, the EU’s policy towards its eastern neighbours was split up. The internal unintended consequence of the EU’s choice to leave its policy unaltered was a tension between the objective of privileged relations with ENP countries and a promise to recognise the interests of Russia as an equal partner. Externally, the unintended outcome was that this fostered two opposing strategic environments: a cooperative one for the EaP and a competitive one with Russia. In terms of the management of unintended consequences, the EU has actively sought to reinforce its normative hegemony towards EaP countries, while at the same time mitigating certain negative unintended effects
The challenges of renewed independence: The Baltic states since 1991
This article offers a comparative assessment of how successfully Estonia, Latvia, and Lithuania have coped with the challenges of renewed independence since 1991, focusing on various aspects of political, economic, and social development. In the post-communist context the Baltic states have clearly outpaced other former Soviet republics and also performed reasonably well in comparison to the countries of Eastern Europe. The convergence of the Baltic experience, which began already in the early 20th century, has continued in the recent past as well, as the three states have adopted a number of similar approaches in domestic politics, the search for security, and economic policy. They also face a number of similar unsolved problems, including considerable political alienation, tensions in relations with Russia, socioeconomic disparity, and demographic challenges. The most important difference in the issues confronting the Baltic states today continues to be the large non-Baltic, mainly Russian presence in Estonia and Latvia, a result of Soviet-era policies. How to effect the meaningful integration of a multiethnic society remains a continuing challenge in these two countries. In contrast, population shifts under Soviet rule never became massive in Lithuania, and ethnic relations are a minor issue there today
Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data.
Trio-based whole-exome sequence (WES) data have established confident genetic diagnoses in ∼40% of previously undiagnosed individuals recruited to the Deciphering Developmental Disorders (DDD) study. Here we aim to use the breadth of phenotypic information recorded in DDD to augment diagnosis and disease variant discovery in probands. Median Euclidean distances (mEuD) were employed as a simple measure of similarity of quantitative phenotypic data within sets of ≥10 individuals with plausibly causative de novo mutations (DNM) in 28 different developmental disorder genes. 13/28 (46.4%) showed significant similarity for growth or developmental milestone metrics, 10/28 (35.7%) showed similarity in HPO term usage, and 12/28 (43%) showed no phenotypic similarity. Pairwise comparisons of individuals with high-impact inherited variants to the 32 individuals with causative DNM in ANKRD11 using only growth z-scores highlighted 5 likely causative inherited variants and two unrecognized DNM resulting in an 18% diagnostic uplift for this gene. Using an independent approach, naive Bayes classification of growth and developmental data produced reasonably discriminative models for the 24 DNM genes with sufficiently complete data. An unsupervised naive Bayes classification of 6,993 probands with WES data and sufficient phenotypic information defined 23 in silico syndromes (ISSs) and was used to test a "phenotype first" approach to the discovery of causative genotypes using WES variants strictly filtered on allele frequency, mutation consequence, and evidence of constraint in humans. This highlighted heterozygous de novo nonsynonymous variants in SPTBN2 as causative in three DDD probands
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
The Authoritarian Past and South European Democracies: an introduction
It is the object of the contributors to this volume to compare how Southern European
democracies have reacted to past authoritarian regimes. This introduction has three
sections. In the first we seek to frame the concepts of authoritarian legacies, transitional
justice and the politics of the past as they are applied here. In the second we analyse the
forms of transitional justice that were present during the processes of democratisation in
Southern Europe, while the third section presents an outline of the volume and of the
contributions made by its authors
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