How genomics can help biodiversity conservation

The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main approaches and applications in biodiversity and conservation genomics, considering practical factors, such as cost, time, prerequisite skills, and current shortcomings of applications. Most approaches perform best in combination with reference genomes from the target species or closely related species. We review case studies to illustrate how reference genomes can facilitate biodiversity research and conservation across the tree of life. We conclude that the time is ripe to view reference genomes as fundamental resources and to integrate their use as a best practice in conservation genomics.info:eu-repo/semantics/publishedVersio

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Peculiaridades do transtorno obsessivo-compulsivo na infância e na adolescência

<abstract language="eng">Obsessive-compulsive disorder (OCD) has a bimodal age of onset and a range of treatment outcomes. Although most of the studies carried out so far have considered childhood and adult forms of OCD as the same disorder, more recent data have suggested that OCD children, as well as adults with an early onset of their obsessive-compulsive symptoms, may represent a distinct subgroup. This review briefly summarizes the most common clinical characteristics of the OCD presentation in children and adolescents, shows data reinforcing the idea that age of onset may be an important distinguishing feature and discusses the importance of a systematic assessment of age of onset for identifying more homogeneous subgroups of OCD patients

Genetics of early-onset obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is characterized by recurrent, intrusive and disturbing thoughts as well as by repetitive stereotypic behaviors. Epidemiological data are similar in children and adults, i.e., between 1 and 3% of the general population suffer from OCD. Children with OCD are often seriously impaired in their development. OCD, especially of early onset, has been shown to be familial. Several candidate genes of predominantly neurotransmitter systems have been analyzed and a total of three genome-wide linkage scans have been performed until now. Analyses of candidate genes in linkage regions have not provided evidence for their involvement in OCD, with the exception of the glutamate transporter gene SLC1A1 on 9p24. Genome-wide association analyses are in progress and the results will promote further independent replication studies. The consideration of subtypes regarding age of onset, symptom dimensions and/or comorbid disorders is needed