12 research outputs found
Breaking Functional Connectivity into Components: A Novel Approach Using an Individual-Based Model, and First Outcomes
- Author
- A Baldi
- A Desrochers
- A Uezu
- A Zetterberg
- AC Lees
- AC Martensen
- AW King
- B Gruber
- BA Santos
- C Banks-Leite
- C Banks-Leite
- C Gagne
- C Murcia
- CB Baniya
- Claudia Dislich
- CR Fonseca
- CS Gillies
- D Boscolo
- D Foguekem
- D Kuefler
- D Storch
- DA Roshier
- DF Doak
- DW Macdonald
- E Revilla
- E Revilla
- EE Crone
- FPL de Melo
- G Pe'er
- G Pe'er
- G Pe'er
- GA Zurita
- GA Zurita
- GA Zurita
- GP Malanson
- Guy Pe'er
- HR Pulliam
- I Hanski
- I Hanski
- IN Bronstein
- J Dover
- J Harte
- J Reif
- JC Manolis
- JH Brown
- JM Calabrese
- JM Fryxell
- JM Marzluff
- JM Morales
- JW Beltran
- K Henle
- K Henle
- K McGarigal
- K Riitters
- K Watts
- K Wiegand
- KA With
- KA With
- Karin Frank
- KJ Haynes
- Klaus Henle
- KR Crooks
- KS Van Houtan
- L Fahrig
- L Fahrig
- L Hansson
- L Ries
- L Szemethy
- L Tischendorf
- M Awade
- M Baguette
- M Belisle
- M Belisle
- M Delibes
- M Delibes
- M Ferrer
- MA Bowers
- MC Ribeiro
- MD Delgado
- MJ Mazerolle
- ML Luhrs
- MM Hansbauer
- MM Hansbauer
- MM Hansbauer
- MM Hansbauer
- N Myers
- N Myers
- N Schtickzelle
- NH Schumaker
- NM Haddad
- OJ Burton
- OJ Robertson
- P Turchin
- P Visconti
- P Vogt
- PA Zollner
- PA Zollner
- PD Taylor
- PF Develey
- PG Risser
- R Nathan
- RD Semlitsch
- RM Ewers
- RS Cantrell
- S Kark
- S Kark
- S Kramer-Schadt
- SA Hinsley
- SCF Palmer
- Sean A. Rands
- SK Heinz
- SL Lima
- T Hovestadt
- T Mueller
- T Mueller
- T Wiegand
- TR Lookingbill
- V Braunisch
- V Grimm
- V Grimm
- V Grimm
- V Grimm
- V Grimm
- VM Stevens
- WE Kunin
- WF Laurence
- WZ Lidicker
- Y Turcotte
- YK Li
- Publication venue
- Public Library of Science
- Publication date
- 01/08/2011
- Field of study
Landscape connectivity is a key factor determining the viability of populations in fragmented landscapes. Predicting ‘functional connectivity’, namely whether a patch or a landscape functions as connected from the perspective of a focal species, poses various challenges. First, empirical data on the movement behaviour of species is often scarce. Second, animal-landscape interactions are bound to yield complex patterns. Lastly, functional connectivity involves various components that are rarely assessed separately. We introduce the spatially explicit, individual-based model FunCon as means to distinguish between components of functional connectivity and to assess how each of them affects the sensitivity of species and communities to landscape structures. We then present the results of exploratory simulations over six landscapes of different fragmentation levels and across a range of hypothetical bird species that differ in their response to habitat edges. i) Our results demonstrate that estimations of functional connectivity depend not only on the response of species to edges (avoidance versus penetration into the matrix), the movement mode investigated (home range movements versus dispersal), and the way in which the matrix is being crossed (random walk versus gap crossing), but also on the choice of connectivity measure (in this case, the model output examined). ii) We further show a strong effect of the mortality scenario applied, indicating that movement decisions that do not fully match the mortality risks are likely to reduce connectivity and enhance sensitivity to fragmentation. iii) Despite these complexities, some consistent patterns emerged. For instance, the ranking order of landscapes in terms of functional connectivity was mostly consistent across the entire range of hypothetical species, indicating that simple landscape indices can potentially serve as valuable surrogates for functional connectivity. Yet such simplifications must be carefully evaluated in terms of the components of functional connectivity they actually predict
Capacidade antioxidante e composição química da casca de maracujá (Passiflora edulis)
- Author
- AGARWAL M.
- AJILA C.M.
- ARVANITOYANNIS I.S.
- BENZIE I.F.
- BLIGH E.G.
- BRACA A.
- CHAU C.-F.
- Cinthia Baú Betim Cazarin
- CONTRERAS-CALDERÓN J.
- DA SILVA J. K.
- DA SILVA J.K.
- GOÑI I.
- JANEBRO D. I.
- JIMENEZ-ESCRIG A.
- Juliana Kelly da Silva
- LABUZA T.P.
- LARRAURI J.A.
- LEWIS B.J.
- MARTINEZ R.
- MELETTI L.M.M.
- Mário Roberto Maróstica Junior
- PRIOR R.L.
- PROSKY L.
- QUEIROZ M.S.R.
- RAMFUL D.
- RAMOS A.T.
- Ricardo de Lima Zollner
- SCHNEEMAN B.O.
- SILVA D.C.
- SILVA S.R.D.
- SIMIRGIOTIS M.J.
- SPAGOLLA L.C.
- SWAIN T.
- Talita Cristina Colomeu
- TANG Y.
- TEHRANIFAR A.
- VUKSAN V.
- WACHIRASIRI P.
- YAPO B.M.
- ZERAIK M.L.
- ZERAIK M.L.
- ZERAIK M.L.
- ZERAIK M.L.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Whey protein isolate hydrolysates obtained with free and immobilized alcalase: characterization and detection of residual allergens
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 13/11/2017
- Field of study
Protein antigenicity can be reduced by enzymatic hydrolysis, which can be performed either by free or immobilized enzyme. The immobilized enzyme is removed from the reaction medium and reused, while the free enzyme must be inactivated to stop the reaction83112120FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO2013/08552-2sem informaçã
Oxidative Stress And Susceptibility To Mitochondrial Permeability Transition Precedes The Onset Of Diabetes In Autoimmune Non-obese Diabetic Mice.
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- 27/11/2015
- Field of study
Beta cell destruction in type 1 diabetes (TID) is associated with cellular oxidative stress and mitochondrial pathway of cell death. The aim of this study was to determine whether oxidative stress and mitochondrial dysfunction are present in T1D model (non-obese diabetic mouse, NOD) and if they are related to the stages of disease development. NOD mice were studied at three stages: non-diabetic, pre-diabetic, and diabetic and compared with age-matched Balb/c mice. Mitochondria respiration rates measured at phosphorylating and resting states in liver and soleus biopsies and in isolated liver mitochondria were similar in NOD and Balb/c mice at the three disease stages. However, NOD liver mitochondria were more susceptible to calcium-induced mitochondrial permeability transition as determined by cyclosporine-A-sensitive swelling and by decreased calcium retention capacity in all three stages of diabetes development. Mitochondria H2O2 production rate was higher in non-diabetic, but unaltered in pre-diabetic and diabetic NOD mice. The global cell reactive oxygen species (ROS), but not specific mitochondria ROS production, was significantly increased in NOD lymphomononuclear and stem cells in all disease stages. In addition, marked elevated rates of 2',7'-dichlorodihydrofluorescein (H2DCF) oxidation were observed in pancreatic islets from non-diabetic NOD mice. Using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) and lipidomic approach, we identified oxidized lipid markers in NOD liver mitochondria for each disease stage, most of them being derivatives of diacylglycerols and phospholipids. These results suggest that the cellular oxidative stress precedes the establishment of diabetes and may be the cause of mitochondrial dysfunction that is involved in beta cell death.481494-50
High Emigration Propensity and Low Mortality on Transfer Drives Female-Biased Dispersal of Pyriglena leucoptera in Fragmented Landscapes
- Author
- A Aleixo
- A Desrochers
- A Ibarra-Macias
- A Pusey
- A Raim
- A Trochet
- A Uezu
- AL Clarke
- Alessio Mortelliti
- AT Oliveira-Filho
- C Duca
- CA Morrison
- Carlos Candia-Gallardo
- Cintia Cornelius
- CS Gillies
- CS Gillies
- D Bonte
- D Boscolo
- D Boscolo
- D Collett
- D Costantini
- DE Bowler
- DE Bowler
- E Huhta
- E Mathyssen
- EO Willis
- G Forero-Medina
- H Andrén
- H Sick
- HN Comins
- JA Prevedello
- Jean Paul Metzger
- JMJ Travis
- KE Mabry
- KP Burnham
- KR Crooks
- L Acharya
- L Fahrig
- L Fahrig
- M Awade
- M Baguette
- M Bélisle
- Marcelo Awade
- MC Ribeiro
- MG Betts
- MM Hansbauer
- MM Hansbauer
- NC Stenseth
- O Ovaskainen
- PA Zollner
- PA Zollner
- PA Zollner
- PJ Greenwood
- R Kays
- R Kenward
- R Nathan
- R Nathan
- RA Ims
- RA Kiltie
- RP Moore
- S Dale
- S Dale
- S Saura
- S Woltmann
- SL Lima
- TD Castellón
- V Grimm
- VO Nams
- WD Hamilton
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Stochastic Optimal Foraging: Tuning Intensive and Extensive Dynamics in Random Searches
- Author
- A James
- A James
- A Kacelnick
- AM Hein
- AM Reynolds
- AM Reynolds
- AM Reynolds
- AM Reynolds
- AM Reynolds
- D Campos
- DJ Anderson
- EP Raposo
- EP Raposo
- Ernesto P. Raposo
- EW Montroll
- F Bartumeus
- F Bartumeus
- F Bartumeus
- F Bartumeus
- F Jacob
- Frederic Bartumeus
- G Hoffmann
- Gandhimohan M. Viswanathan
- GM Viswanathan
- GM Viswanathan
- IC Cuthill
- L Liang
- M de Jager
- M de Jager
- MA Lomholt
- Marcos G. E. da Luz
- Mark D. McDonnell
- MC Santos
- MF Shlesinger
- MGE da Luz
- MJ Plank
- ND Dees
- ND Dees
- O Bénichou
- O Bénichou
- PA Zollner
- PA Zollner
- R Kawaii
- S Benhamou
- SA Kauffman
- SA Levin
- SL Lima
- SV Buldyrev
- SV Buldyrev
- TW Shoener
- VAA Jansen
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M.
- Abdullah T.
- Abe R.
- Abe S.
- Abecasis G. R.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acosta-Herrera M.
- Acquilini D.
- Adachi T.
- Adachi Y.
- Adams C.
- Adams K.
- Adanini O.
- Adeleye O.
- Adeniji K.
- Adra D.
- Afifi N.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Afset J. E.
- Agasou A.
- Aghemo A.
- Agranoff D.
- Agrawal S.
- Aguirre L. A.
- Agwuh K.
- Ahmad H. F.
- Ahmad N.
- Ahmed A.
- Ahmed C.
- Ahmed K. A.
- Ai M.
- Ail D.
- Akeroyd L.
- Akhtar M. N.
- Akhtar S.
- Akinkugbe O.
- Aksentijevich A.
- Al Thani A.
- Al-Muftah W.
- Al-Sarraj Y.
- Alarcon C.
- Alarcon-Riquelme M. E.
- Alasdair F.
- Alaverdian D.
- Alavere H.
- Albertos R.
- Albillos A.
- Albrecht W.
- Albrich W.
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- Aldera E. L.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Oxidative stress and susceptibility to mitochondrial permeability transition precedes the onset of diabetes in autoimmune non-obese diabetic mice
- Author
- A. C. R. Leite
- A. E. Vercesi
- Alberici LC
- Alberici LC
- Anderson MS
- Augstein P
- Babad J
- Bao S
- Barcellos-de-Souza P
- Barlovic DP
- Barthson J
- Bonnard C
- Brookes PS
- C. Malaguti
- Chicco AJ
- D. N. Oliveira
- Degasperi GR
- Degasperi GR
- Figueira TR
- Figueira TR
- Fiorina P
- Gauss KA
- Giacco F
- Gurzov EN
- H. C. F. Oliveira
- Han X
- He CJ
- Herlein JA
- Herzog EL
- Hidalgo C
- Hidalgo C
- Huhn R
- Imai Y
- Kaplan RS
- Kim CH
- Kowaltowski AJ
- Kowaltowski AJ
- Kowaltowski AJ
- Kumar S
- Leite AC
- Lemasters JJ
- Liang K
- Ma ZA
- Makino S
- Martinez-Abundis E
- Murphy AN
- Oliveira HC
- P. G. La Guardia
- Paim BA
- Patergnani S
- Payne CM
- Peter-Katalinic J
- R. L. de Lima Zollner
- R. R. Catharino
- Rabinovitch A
- Rizzuto R
- Rizzuto R
- Thomas HE
- Ventura-Oliveira D
- Vercesi AE
- Zong H
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Landscape connectivity and animal behavior: functional grain as a key determinant for dispersal
- Author
- A Coulon
- A Moilanen
- A Sih
- A Sih
- AAG Rittenhouse
- AF Bennet
- BJ Goodwin
- CB Schultz
- CB Schultz
- CG Johnson
- CJ Johnson
- CP Doncaster
- CR Haag
- D Vanvuren
- DA Roff
- DA Roff
- DE Bowler
- DF Fraser
- DR Bowne
- DS Wilson
- DS Wilson
- E Michels
- E Revilla
- ED Doerr
- EM Bayne
- F Adriaensen
- F Burel
- G Gundersen
- G Mennechez
- G Verbeylen
- H Dingle
- H Dyck Van
- H Dyck Van
- Hans Van Dyck
- HF Sakai
- I Hanski
- I Hanski
- I Hanski
- I Hanski
- I Olivieri
- J Clobert
- J Clobert
- J Pither
- JA Stamps
- JA Wiens
- JE Smith
- JF Le Galliard
- JM Calabrese
- JM Morales
- JW Dover
- JY Lemel
- KJ Haynes
- L Bosschieter
- L Tischendorf
- L Tischendorf
- M Baguette
- M Baguette
- M Baguette
- M Baguette
- M Belisle
- M Belisle
- MA Baars
- MA Rankin
- MA Rankin
- Michel Baguette
- N Keyghobadi
- N Kotliar
- N Schtickzelle
- N Schtickzelle
- N Schtickzelle
- NJ Dingemanse
- NM Haddad
- NM Haddad
- OL Sutcliffe
- P Casula
- PA Zollner
- PD Taylor
- PD Taylor
- PJ Drent
- PT McDougall
- R Altwegg
- R Jongman
- R Winfree
- RA Ims
- RL Schooley
- RLH Dennis
- RTT Forman
- S Barbaresi
- S Belichon
- S Hein
- S Schadt
- S Vuilleumier
- SF Matter
- SL Lima
- SN Vignieri
- T Merckx
- TD Castellon
- TM Wiegand
- TM Wiegand
- V Grimm
- VJ Bakker
- VM Stevens
- VM Stevens
- VM Stevens
- WB Watt
- WJ Bell
- YK Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
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- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
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- Baba R
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- Badia JR
- Badji RM
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- Chadwick D
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- Chandler B
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- Cornely OA
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- Cortes B
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- Cosier T
- Cossarizza A
- Costantino G
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- Coton Z
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- Coviello DA
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- de Gordoa LO-R
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- De Grandi A
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- De la Horra C
- De Neef M
- de Pablo R
- de Rojas I
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- De Vivo O
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- Desanctis E
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- di Bartolomeo C
- Di Biagio A
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- Di Pietro M
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- Zanelli G
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- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease