House Bill 1024: A Chronology

In speaking to those assembled for Legislative Day, Tim Oksman, lobbyist for HB1024 stated that the bill\u27s passage against all odds was a tribute to the respect that the legislators have for the Nursing Profession. For persons interested in the political process surrounding HB1024 this chronology is written. If at times it seems repetitive, it\u27s because the process was. The same core group of people, give or take a couple, said the same things to different people over and over again. Perhaps it is important to emphasize both the frustration and necessity of this repetition and that patience is needed to succeed. In writing this chronology, we realize that we probably haven\u27t told the whole story. We are, therefore, interested in hearing from others who may have been in private practice before or who know of information regarding this or previous attempts to achieve independent practice in the state. We would like to view the total process in addition to the one we remember

Therapeutic Hypothermia after Cardiac Arrest: Experience at an Academically Affiliated Community-Based Veterans Affairs Medical Center

At laboratory and clinical levels, therapeutic hypothermia has been shown to improve neurologic outcomes and mortality following cardiac arrest. We reviewed each cardiac arrest in our community-based Veterans Affairs Medical Center over a three-year period. The majority of cases were in-hospital arrests associated with initial pulseless electrical activity or asystole. Of a total of 100 patients suffering 118 cardiac arrests, 29 arrests involved comatose survivors, with eight patients completing therapeutic cooling. Cerebral performance category scores at discharge and six months were significantly better in the cooled cohort versus the noncooled cohort, and, in every case except for one, cooling was offered for appropriate reasons. Mean time to initiation of cooling protocol was 3.7 hours and mean time to goal temperature of 33°C was 8.8 hours, and few complications clearly related to cooling were noted in our case series. While in-patient hospital mortality of cardiac arrest was high at 65% mortality during hospital admission, therapeutic hypothermia was safe and feasible at our center. Our cooling times and incidence of favorable outcomes are comparable to previously published reports. This study demonstrates the feasibility of implementing, a cooling protocol a community setting, and the role of neurologists in ensuring effective hospital-wide implementation

Dietary Response of Sympatric Deer to Fire Using Stable Isotope Analysis of Liver Tissue

Carbon (δ13C) and nitrogen (δ15N) isotopes in biological samples from large herbivores identify photosynthetic pathways (C3 vs. C4 ) of plants they consumed and can elucidate potential nutritional characteristics of dietary selection. Because large herbivores consume a diversity of forage types, δ13C and δ15N in their tissue can index ingested and assimilated diets through time. We assessed δ13C and δ15N in metabolically active liver tissue of sympatric mule deer (Odocoileus hemionus) and white-tailed deer (O. virginianus) to identify dietary disparity resulting from use of burned and unburned areas in a largely forested landscape. Interspecific variation in dietary disparity of deer was documented 2–3 years post-fire in response to lag-time effects of vegetative response to burning and seasonal (i.e., summer, winter) differences in forage type. Liver δ13C for mule deer were lower during winter and higher during summer 2 years post-fire on burned habitat compared to unburned habitat suggesting different forages were consumed by mule deer in response to fire. Liver δ15N for both species were higher on burned than unburned habitat during winter and summer suggesting deer consumed more nutritious forage on burned habitat during both seasons 2 and 3 years post-fire. Unlike traditional methods of dietary assessment that do not measure uptake of carbon and nitrogen from dietary components, analyses of stable isotopes in liver or similar tissue elucidated δ13C and δ15N assimilation from seasonal dietary components and resulting differences in the foraging ecology of sympatric species in response to fire

Dietery Response of Sympatric Deer to Fire Using Stable ISotope Analysis of Liver Tissue

Carbon (δ13C) and nitrogen (δ15N) isotopes in biological samples from large herbivores identify photosynthetic pathways (C3 vs. C4 ) of plants they consumed and can elucidate potential nutritional characteristics of dietary selection. Because large herbivores consume a diversity of forage types, δ13C and δ15N in their tissue can index ingested and assimilated diets through time. We assessed δ13C and δ15N in metabolically active liver tissue of sympatric mule deer (Odocoileus hemionus) and white-tailed deer (O. virginianus) to identify dietary disparity resulting from use of burned and unburned areas in a largely forested landscape. Interspecific variation in dietary disparity of deer was documented 2–3 years post-fire in response to lag-time effects of vegetative response to burning and seasonal (i.e., summer, winter) differences in forage type. Liver δ13C for mule deer were lower during winter and higher during summer 2 years post-fire on burned habitat compared to unburned habitat suggesting different forages were consumed by mule deer in response to fire. Liver δ15N for both species were higher on burned than unburned habitat during winter and summer suggesting deer consumed more nutritious forage on burned habitat during both seasons 2 and 3 years post-fire. Unlike traditional methods of dietary assessment that do not measure uptake of carbon and nitrogen from dietary components, analyses of stable isotopes in liver or similar tissue elucidated δ13C and δ15N assimilation from seasonal dietary components and resulting differences in the foraging ecology of sympatric species in response to fire

Dimethylsulfoxide exposure modulates HL-60 cell rolling interaction

Human leukaemic HL-60 cells are widely used for studying interactions involving adhesion molecules [e.g. P-selectin and PSGL-1 (P-selectin glycoprotein ligand-1)] since their rolling behaviour has been shown to mimic the dynamics of leucocyte rolling in vitro. HL-60 cells are neutrophilic promyelocytes that can undergo granulocytic differentiation upon exposure to compounds such as DMSO (dimethylsulfoxide). Using a parallel plate flow chamber functionalized with recombinant P-selectin–Fc chimaera, undifferentiated and DMSO-induced (48, 72 and 96 h) HL-60 cells were assayed for rolling behaviour. We found that depending on P-selectin incubation concentration, undifferentiated cells incurred up to a 6-fold increase in rolling velocity while subjected to an approximately 10-fold increase in biologically relevant shear stress. HL-60 cells exposed to DMSO for up to 72 h incurred up to a 3-fold increase in rolling velocity over the same shear stress range. Significantly, cells exposed for up to 96 h incurred up to a 9-fold decrease in rolling velocity, compared with undifferentiated HL-60 cells. Although cell surface and nuclear morphological changes were evident upon exposure to DMSO, flow cytometric analysis revealed that PSGL-1 expression was unchanged, irrespective of treatment duration. The results suggest that DMSO-treated HL-60 cells may be problematic as a substitute for neutrophils for trafficking studies during advanced stages of the LAC (leucocyte adhesion cascade). We suggest that remodelling of the cell surface during differentiation may affect rolling behaviour and that DMSO-treated HL-60 cells would behave differently from the normal leucocytes during inflammatory response in vivo

Global Savings, Assets and Financial Inclusion: Lessons, Challenges, and Directions

Global Savings, Assets and Financial Inclusion: Lessons, Challenges, and Direction

Large Scale Composite Manufacturing for Heavy Lift Launch Vehicles

Risk reduction for the large scale composite manufacturing is an important goal to produce light weight components for heavy lift launch vehicles. NASA and an industry team successfully employed a building block approach using low-cost Automated Tape Layup (ATL) of autoclave and Out-of-Autoclave (OoA) prepregs. Several large, curved sandwich panels were fabricated at HITCO Carbon Composites. The aluminum honeycomb core sandwich panels are segments of a 1/16th arc from a 10 meter cylindrical barrel. Lessons learned highlight the manufacturing challenges required to produce light weight composite structures such as fairings for heavy lift launch vehicles

The Ursinus Weekly, November 2, 1972

Election 1972: Vote! • Ecology group gears up truck • The U.C. Student Activities Committee divides eleven thousand dollars • Negative demerit proposal accepted by administration • Specks burns • Halloween dance draws one hundred fifty people, or U.C., the east coast\u27s number one suitcase college • Editorial: The Rot • Spotlight: Cris Crane • Fidler on the wax: Close to the edge • Forum guest Fred Kolb: mentalist or magician? • West Chester vs Ursinus: What a game! • Harriers bounce back! • Won, lost, and tied • Sports buff\u27s cornerhttps://digitalcommons.ursinus.edu/weekly/1090/thumbnail.jp

Why are Some Engaged and Not Others? Explaining Environmental Engagement among Small Firms in Tourism

This paper examines the reasons for different levels of environmental engagement among small firms in tourism. Drawing on theories of motivation, notably Social Cognitive Theory, Motivation Systems Theory and Goal Orientation Theory, as well as the literature on environmental sensitivity, it proposes a novel conceptual framework that is subsequently used to inform an empirical study. The findings of the research suggest that varying levels of environmental engagement may be explained by differences in worldviews, self-efficacy beliefs, context beliefs and goal orientation. The paper concludes by considering the policy implications of the results. © 2011 John Wiley & Sons, Ltd

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

Cullin-RING ligases are multisubunit E3 ubiquitin ligases that recruit substrate-specific adaptors to catalyze protein ubiquitylation. Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recognition into a single multidomain protein, of which the best known are BTB-BACK-Kelch domain proteins, including KEAP1. Cul3 assembly requires a BTB protein "3-box" motif, analogous to the F-box and SOCS box motifs of other Cullin-based E3s. To define the molecular basis for this assembly and the overall architecture of the E3, we determined the crystal structures of the BTB-BACK domains of KLHL11 both alone and in complex with Cul3, along with the Kelch domain structures of KLHL2 (Mayven), KLHL7, KLHL12, and KBTBD5. We show that Cul3 interaction is dependent on a unique N-terminal extension sequence that packs against the 3-box in a hydrophobic groove centrally located between the BTB and BACK domains. Deletion of this N-terminal region results in a 30-fold loss in affinity. The presented data offer a model for the quaternary assembly of this E3 class that supports the bivalent capture of Nrf2 and reveals potential new sites for E3 inhibitor design