Lysosome-Associated Membrane Protein-1 (LAMP-1) Is the Melanocyte Vesicular Membrane Glycoprotein Band II

Coated vesicles play a critical role in the process of melanogenesis. Antisera raised against a coated vesicle fraction from mouse melanoma cells recognize two major glycoprotein antigens, band I (47-55 kd) and band II (90-120 kd). We demonstrate that band II is lysosome-associated membrane protein 1 (LAMP-1) by the following criteria: 1) the molecular weight and abundance of LAMP-1 varies among tissues but is always identical to that of band II; 2) band II and LAMP-1 co-migrate in sucrose gradient sedimentation studies; 3) immunodepletion of cell extracts with antivesicle serum removes all LAMP-1; and 4) intact organelles immunoisolated with antivesicle serum contain band II and LAMP1. Our results further confirm the long-suspected relationship between melanosomes and the lysosomal lineage of organelles

Angular Dependence of ϕ

The dependence of ϕ-meson photoproduction on the polar angle is investigated in the framework of a multisource thermal model. We present a detailed comparison between our results and experimental data of the neutral decay mode in the reaction γp→pϕ(KSKL). The results are in good agreement with the experimental data. It is found that the movement factor bz increases linearly with the photon beam energies

Practical ID-based encryption for wireless sensor network

In this paper, we propose a new practical identity-based encryption scheme which is suitable for wireless sensor network (WSN). We call it \textit{Receiver-Bounded Online/Offline Identity-based Encryption} (RB-OOIBE). It splits the encryption process into two parts -- the offline and the online part. In the offline part, all heavy computations are done without the knowledge of the receiver\u27s identity and the plaintext message. In the online stage, only light computations such as modular operation and symmetric key encryption are required, together with the receiver\u27s identity and the plaintext message. Moreover, since each offline ciphertext can be re-used for the same receiver, the number of offline ciphertexts the encrypter holds only confines the number of receivers instead of the number of messages to be encrypted. In this way, a sensor node (with limited computation power and limited storage) in WSN can send encrypted data easily: A few offline ciphertexts can be computed in the manufacturing stage while the online part is light enough for the sensor to process. We propose an efficient construction for this new notion. The scheme can be proven selective-ID CCA secure in the standard model. Compared to previous online/offline identity-based encryption schemes, our scheme is exempt from a high storage requirement, which is proportional to the number of messages to be sent. The improvement is very significant if many messages are sent to few receivers

Experimental study of an ORC (organic Rankine cycle) for low grade waste heat recovery in a ceramic industry

This paper deals about an experimental application of an ORC (organic Rankine cycle) in a ceramic industry for low grade waste heat recovery. The ORC module used in this application was initially designed and constructed to satisfy the main specifications for an efficient power system, highlighting a volumetric expander with large built-in volume ratio. Furthermore, the performance of the ORC was experimentally characterized in a test bench in a previous work, achieving a maximum gross electrical efficiency of 12.32%. Taking this as a starting point, the aim of this work is to verify the performance of this ORC operating in actual industrial conditions, besides to profiting the information extracted from the application to assess its profitability. For this, the system performance is experimentally characterized in the industry, discussing and comparing the results obtained to laboratory data. From these experimental results a model of the system is developed, which allows predicting the net electrical production of the system along a typical year of operation and quantifying the energy and environmental benefits of the project. Moreover, from the electrical generation, investment costs required and industrial electricity price, a feasibility study is conducted to address the profitability of the application.The authors are indebted to the Minister of industry of 'Generalitat Valenciana' (Spain) for its financial assistance under project INIDIV2010022 and Rank (R), the ORC manufacturer, for its support in this project. Also to thank greatly the Jaume I University for its financial support under the PhD grant PREDOC/2013/28 of 'Convocatoria d'ajudes predoctorals per a la formacio de personal investigador del Pla de promocio de la investigacio de la Universitat Jaume I de Castello (Spain)'.Peris, B.; Navarro-Esbri, J.; Moles, F.; Mota Babiloni, A. (2015). Experimental study of an ORC (organic Rankine cycle) for low grade waste heat recovery in a ceramic industry. Energy. 85:534-542. https://doi.org/10.1016/j.energy.2015.03.065S5345428

A superconducting nanowire photon number resolving four-quadrant detector-based Gigabit deep-space laser communication receiver prototype

Deep space explorations require transferring huge amounts of data quickly from very distant targets. Laser communication is a promising technology that can offer a data rate of magnitude faster than conventional microwave communication due to the fundamentally narrow divergence of light. This study demonstrated a photon-sensitive receiver prototype with over Gigabit data rate, immunity to strong background photon noise, and simultaneous tracking ability. The advantages are inherited from a joint-optimized superconducting nanowire single-photon detector (SNSPD) array, designed into a four-quadrant structure with each quadrant capable of resolving six photons. Installed in a free-space coupled and low-vibration cryostat, the system detection efficiency reached 72.7%, the detector efficiency was 97.5%, and the total photon counting rate was 1.6 Gcps. Additionally, communication performance was tested for pulse position modulation (PPM) format. A series of signal processing methods were introduced to maximize the performance of the forward error correction (FEC) code. Consequently, the receiver exhibits a faster data rate and better sensitivity by about twofold (1.76 photons/bit at 800 Mbps and 3.40 photons/bit at 1.2 Gbps) compared to previously reported results (3.18 photon/bit at 622 Mbps for the Lunar Laser Communication Demonstration). Furthermore, communications in strong background noise and with simultaneous tracking ability were demonstrated aimed at the challenges of daylight operation and accurate tracking of dim beacon light in deep space scenarios

Controlling the Bureaucracy of the Antipoverty Program

Rapid progress made in various areas of regenerative medicine in recent years occurred both at the cellular level, with the Nobel prize-winning discovery of reprogramming (generation of induced pluripotent stem (iPS) cells) and also at the biomaterial level. The use of four transcription factors, Oct3/4, Sox2, c-Myc, and Klf4 (called commonly "Yamanaka factors") for the conversion of differentiated cells, back to the pluripotent/embryonic stage, has opened virtually endless and ethically acceptable source of stem cells for medical use. Various types of stem cells are becoming increasingly popular as starting components for the development of replacement tissues, or artificial organs. Interestingly, many of the transcription factors, key to the maintenance of stemness phenotype in various cells, are also overexpressed in cancer (stem) cells, and some of them may find the use as prognostic factors. In this review, we describe various methods of iPS creation, followed by overview of factors known to interfere with the efficiency of reprogramming. Next, we discuss similarities between cancer stem cells and various stem cell types. Final paragraphs are dedicated to interaction of biomaterials with tissues, various adverse reactions generated as a result of such interactions, and measures available, that allow for mitigation of such negative effects