Study the role of Estradiol and Luteinizing hormones in breast tumors incidence in the women in Al-Najaf Governorate- Iraq

This study aims to illustration the role of some important risk factors which including age, age at menarche , menopausal status, the levels of estradiol(E2) and luteinizing hormones(LH) in the increasing breast tumors incidence by using 120 women, divided into three groups; control group including forty healthy women, benign group containing forty women with breast benign tumor and malignant group of forty women with malignant breast tumor, this last group subdivided into; malignant presurgery and malignant post surgery groups each one contain twenty women.    The results showed that benign breast tumors are  more common in women with interval age 31-40 years whereas malignant breast tumors were more common in women with interval age 41-50 years. Early age at menarche wasn’t significantly associated with increasing breast cancer incidence, contrariwise menopausal status which was significantly associated with increasing this disease .   The results revealed a significant elevation P? 0.05 in the levels of estradiol E2, and Luteinizing hormones in the women with breast cancer before tumor excision and reduction in the levels of these hormones in the women after tumor excision indicating the role of these hormones in the initiation or promotion breast cancer. In conclusion, this study revealed that breast cancer incidence increased in women in forties and fifties of age and increasing the levels of endogenous hormones such as Estradiol, and luteinizing hormones can increased risk of developing breast cancer especially in postmenopausal women. Key word : Brest cancer  , Risk factor ,  Estradiol(E2) ,  luteinizing hormone

Protective Activity of Glycyrrihzaglabra against Histopathological Changes in White Albino Rats

The study was aimsto evaluation the protective activity of methanol-water extract of Glycyrrihzaglabraroot (GL) against histopathological changes induced by cyclophosphamide in white albino rats. Multiple doses for drug and extract were used to investigate the accumulation effect of drug and extract onliver and kidney. Results show that drug causes different harmful changes in rat organs in all doses concentrations used in study and extract have protective activity to prevent changes in tissue in 1000, 750 and 250 mg \kg , but dose 500 was failure to protect liver and lowest effect on kidney. Conclusion of present study is Glycyrrihzaglabrauseful for protective body organs against side effect of drugs and harmful effect of oxidative stress. Keywords: Glycyrrihzaglabra  ,cyclophosphamide, liver, kidney

Total and differential leukocytes count in type 2 diabetes mellitus patients in Iraq

To find the correlation between total and differential leukocytes count and the presence of microalbuminuria in diabetic patients. The results show significant positive correlation between total leukocytes count and microalbuminuria in males and females also there is significant positive correlation between neutrophils count and microalbuminuria in males and females but there is no correlation with other types of leukocytes

Determination Some Minerals in Cancer Tissue

Study was amid to detect sometrace elements in human tumor tissue, Manganese, cobalt, cadmium and Zink was measured in cancer and benign  tissue using atomic absorption ,  result show that cancer tissue have higher concentration of cobalt and Zink than  benign tissue,  it were 156.7±6.5 and 205.79 µg\g respectively.femaleshad higher concentrations  than males in cancer 2011.41±439.79, 114..54±0.05, 157.05±6.50 206.58±20.93 µg\gin Mn, Cd , Co and Zn respectively also in benign tissue Female 2373.37±703.56, 114.56±0.06, 154.50±29.4, 204.65±28.23 µg\g in the same minerals above. Keywords: trace elements, atomic absorption, tumors tissue

In vivo study of antimutagenic and antioxidant activity of Glycyrrihza glabra root extract

The studying was aimed to inhibition the mutagenecity and oxidation of genomic DNA by use methanol-water extract of Glycyrrihza glabra root (GL) against anticancer drug cyclophosphomide in rats by use DNA fragmentation test, the extract characterized by thin layer chromatography TLC, and antioxidant activity by use β- carotene spray, the experiment design to use tow single dose of GL and single dose of the drug in three interaction, extract before, with and after the drug to investigate the mechanism of which extract effect inside cell. Four multiple doses for drug and extract to investigate the accumulation effect in DNA the results show that extract is contain of different polar compound and have antioxidant activity, so the extract is bio-antimutagenesis and poor dismutagenesis activity, the extract can inhibit accumulation effect of mutagenecity and oxidation activity of the drug

Heavy Metals Concentration Detection in Tumor Tissue

Study was amid to detect some trace elements in human tumor tissue, Manganese, cobalt, cadmium and Zink was measured in cancer and benign  tissue using atomic absorption ,  result show that cancer tissue have higher concentration of cobalt and Zink than  benign tissue,  it were 156.7±6.5 and 205.79 µg\g respectively. females had higher concentrations  than males in cancer 2011.41±439.79, 114..54±0.05, 157.05±6.50 206.58±20.93 µg\g in Mn, Cd , Co and Zn respectively also in benign tissue Female 2373.37±703.56, 114.56±0.06, 154.50±29.4, 204.65±28.23 µg\g in the same minerals above. Keywords: trace elements, atomic absorption, tumors tissue

Detection Some Trace Elements in Human Milk and Effect of Some Factors on its Concentrations

Study aim to determination some trace elements in lactating mothers human milk and study effect different factors on its concentration, Age , Body mass index, Home and Smoking habitat, atomic absorption flame less used to measured (Mn, Cd, Co and Zn) in 70 sample of lactating mothers milk which digested using tricolor acetic acid 24%. Result show that concentration of these elements increasing than normal value of these elements,Mn was 1801.40, Cd was 114.64, Co was 288.52 and Zn was 212.10.Also factors were studied effect on minerals concentration,  increasing age was  non effected on minerals concentration, over weight causes increasing it, urban resident causesincreasing in Mn concentration while rural residence causes increasing in others minerals, negative smoking habitat causes increasing in Cd and Co concentrations. Key words: trace element, lactating mother’s human milk, atomic absorptio

Inhibition the mutagenicity of vitamin a by using Olea europaea extract

This study aims to investigate the predisposition of the extraction of the extract of olive leaves (Olea europaea of the family Oleaceae, or the olive family) to frustrate the excretion of the inherent toxic caused by vitamin A (henceforth VA). After being sure that the extraction is inane of any negative effects on the living creature, the following tests are adopted, the mitotic index test of the medulla ossium of the bones, and the chromosomal aberration test. The results showed that toxic dose of vitamin A have cytogenetic effect. It cusses increased in bone marrow cell proliferation and increase in chromosome malformation, the olea leaf extract showed anti-mutagenic activity against the cytogenetic effect of vitamin A it decrees chromosome malformation and kept the Mitotic index in normal level

Effect of Pollutant Water on Some Organs and Blood Parameters in Rats

Water pollution causes dangerous problems in our life. The present study aims to determination effect of chemical polluted water on blood parameter and histological changes in rat organs using Wight albino rats. For this study Hilla fabric plant waste water is used as drinking water to the rats for 30 days. Results show that polluted water causes increased in W.B.Cs count and histopathological changes in liver and kidne

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal