An Exclusive Window onto Higgs Yukawa Couplings

We show that both flavor-conserving and flavor-violating Yukawa couplings of the Higgs boson to first- and second-generation quarks can be probed by measuring rare decays of the form h->MV, where M denotes a vector meson and V indicates either gamma, W or Z. We calculate the branching ratios for these processes in both the Standard Model and its possible extensions. We discuss the experimental prospects for their observation. The possibility of accessing these Higgs couplings appears to be unique to the high-luminosity LHC and future hadron colliders, providing further motivation for those machines.Comment: 6 pages, 2 figures, 1 tabl

Focus topics for the ECFA study on Higgs / Top / EW factories

In order to stimulate new engagement and trigger some concrete studies in areas where further work would be beneficial towards fully understanding the physics potential of an $e^+e^-$ Higgs / Top / Electroweak factory, we propose to define a set of focus topics. The general reasoning and the proposed topics are described in this document.Comment: v3: fixed spelling of two author

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. Results Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory. Conclusion We conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens.Peer reviewe

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

BackgroundThe Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function.ResultsHere, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory.ConclusionWe conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens.</p

Synthesizing CSCL perspectives on the theory, methods, design, and implementation of future learning spaces

This pre-conference workshop brings together a number of leading learning scientists, as well as talented younger researchers, working in an emerging, but fragmented line of research focused on ‘Future Learning Spaces’ (FLSs). Significant advances in this area of scholarship have been made in recent years, spurred by billions of dollars of investments into building or re-designing educational spaces — both physical and digital, formal and informal — to accommodate learning in a networked society. To advance our theoretical understanding on the role of space in learning, vital work remains to be done to frame concepts, synthesize dispersed research agendas and share the results of work that is relevant to the broader FLSs project. To do this, this workshop is organized in four themes that address current challenges and opportunities for FLSs research: Theory, methods, design, and implementation. The workshop includes a combination of invited presenters and key contributors who have advanced research in this area; and active participants, who are interested in deepening their understanding through active participation in the workshop. The objectives of this symposium are to (1) deepen participants’ understandings of current FLSs research; (2) cross-fertilize related threads of inquiry for mutual gain; (3) rise above the individual threads to develop syntheses between them; and (4) build collaborative partnerships for future work.</p