Citogenetičko oštećenje u turskih radnika na koksnim pećima izloženih policikličkim aromatskim ugljikovodicima: povezanost s genskim polimorfizmima CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1 i GSTP1

The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasinblocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample.Cilj je ovog ispitivanja bio utvrditi učestalost kromosomskih aberacija (CA) i mikronukleusa (CBMN) u limfocitima periferne krvi turskih radnika na koksnim pećima te utjecaj genskih polimorfizama CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1 i GSTP1 na te biopokazatelje. Profesionalna je izloženost ovih radnika značajno povećala učestalost CA i CBMN, ali genski polimorfizmi nisu utjecali na ove parametre bez obzira na to je li se radilo o radnicima ili o kontrolnoj skupini. Međutim, značaj je naših rezultata ograničen zbog malog uzorka te su potrebna daljnja istraživanja s većim uzorkom da ih se potvrdi

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at √s=0.9 and 2.36 TeV

Measurements of inclusive charged-hadron transverse-momentum and pseudorapidity distributions are presented for proton-proton collisions at root s = 0.9 and 2.36 TeV. The data were collected with the CMS detector during the LHC commissioning in December 2009. For non-single-diffractive interactions, the average charged-hadron transverse momentum is measured to be 0.46 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 0.9 TeV and 0.50 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 2.36 TeV, for pseudorapidities between -2.4 and +2.4. At these energies, the measured pseudorapidity densities in the central region, dN(ch)/d eta vertical bar(vertical bar eta vertical bar and pp collisions. The results at 2.36 TeV represent the highest-energy measurements at a particle collider to date

Impact Of Asynchronism on Wireless Relay Channels

In this work, we investigate the effects of asynchronism arised by time delay between the source and relay transmissions over the wireless relay channel. We revise the maximum-a-posteriori (MAP) type detector designed for synchronous case and proposed a receiver for asynchronous relay channel. We also integrate source-relay cooperation with the low density parity check (LDPC) codes in decode and forward (DF) mode to enhance the system performance. The convergence threshold of the overall system is evaluated using extrinsic information transfer (EXIT) chart analysis. Also the performance of asynchronous system is compared with synchronous counterpart via Monte Carlo simulations for various level of delay time. Using the convergence behaviour and simulation results, it's demonstrated that that the proposed receiver can cope with asynchronized transmission over the ergodic fading relay channel

Multilevel Coded Cooperation for Wireless Vehicular Networks

At the physical layer of wireless vehicular networks, coded cooperation is a possible way of realizing uplink transmit diversity at the mobile vehicles equipped with single antenna. In this work, in order to increase the power and bandwidth efficiency, a multilevel coded cooperative system using orthogonal signalling is proposed. Orthogonal signalling not only enables transmission of both users data in single channel symbol but also provides independent detection at the receiver. We investigate the performance of the system by derivation of pairwise and bit error probabilities together with Monte-Carlo simulations

Improving the performance of distributed turbo trellis coding scheme over relay channel

In this work, for a turbo trellis coded communication system over relay channel, system performance is tried to be enhanced by employing different mappings at relay and source. Moreover, considering the trellis encoders at the source and relay together, the trellis of relay encoder is designed to minimize the overall system symbol error rate. The performance of the proposed algoritms are figured out via simulations and superior performance is achieved compared with classical channel coded scheme

Delay Minimization for Massive MIMO Based Cooperative Mobile Edge Computing System With Secure Offloading

Mobile edge computing (MEC) has been envisioned as a promising technology for enhancing the computational capacities of mobile devices by enabling task offloading. In this paper, we present a novel framework for a cooperative MEC system by employing Massive Multiple-Input Multiple-Output (MIMO) and non-orthogonal multiple access (NOMA) technologies, including security aspects. Specifically, in the proposed cooperative MEC system, there is no strong direct transmission link between the cell-edge user and the MEC server; consequently, the user sends their tasks to the MEC server through the helpers at the cell-centers. In the proposed framework, we minimize the overall delay, including secure offloading under the constraints of computing capability and transmit power. The proposed algorithm minimizes the overall delay in downlink and uplink transmission while satisfying security constraints to solve the formulated problem. The simulation results show that Massive MIMO based NOMA improves the performance of the secure MEC system by employing more than one helper

Clinical significance of renal cortical thickness in patients with chronic kidney disease

WOS: 000429225000007PubMed ID: 28618770Purpose: The aim of this study was to evaluate the correlations between laboratory findings and ultrasonographic measurements of renal length and cortical thickness in patients receiving follow-up for chronic kidney disease (CKD). Methods: A total of 41 CKD patients (18 males and 23 females; mean age, 65.2 years; range, 42 to 85 years) with a low glomerular filtration rate who did not require renal replacement therapy were included in this prospective study. Patients were followed up with laboratory assays at bimonthly intervals and with ultrasonography performed twice a year. Renal cortical thickness, renal length, and estimated glomerular filtration rate (eGFR) values were compared using the paired-samples t test. Additionally, Pearson correlation analysis was conducted between renal length and cortical thickness measurements and eGFR values to assess kidney function. Results: At the beginning of the study and after 24 months, mean eGFR values of the 41 patients were 35.92 mL/min and 28.38 mL/min, respectively. The mean renal length was 91.29 mm at the beginning of the study and 90.24 mm at the end of the study. The mean cortical thickness was 5.76 +/- 2.05 mm at the beginning of the study and 5.28 +/- 1.99 mm at the end of the study. A statistically significant positive association was found between eGFR and mean renal length (r= 0.66, P< 0.01) and between eGFR and mean cortical thickness (r= 0.85, P< 0.01), with the latter being more prominent. Conclusion: Our study suggests that ultrasonographic cortical thickness measurements may be an important imaging technique in the follow-up care of patients with CKD

Two Different Causes of Decreased Activity on Ipsilateral Iliac Artery in Renal Transplant Scintigraphy

WOS: 000435346400033PubMed ID: 2974260

Spectrum of nontumoral renal pathologies in tumor nephrectomies: nontumoral renal parenchyma changes

WOS: 000316644700005PubMed ID: 23142019Non-neoplastic changes are not rarely seen in renal parenchyma of nephrectomy specimens removed for primary renal neoplasms. These changes often involve both kidneys, thus causing impairment of renal function, reducing patient's quality of life and sometimes threatening it. Renal tissue accompanying the tumor provides an opportunity in order to evaluate these changes. However, the clinician should make available clinical and laboratory findings involving renal functions of the patient to the pathologist. It is also important that the pathologist must have appropriate knowledge and experience in nephropathology. In this study, we aimed to correlate these changes with the clinical data and make inquiries regarding our experience with nonneoplastic kidney pathology. Consecutive 403 nephrectomy specimens with primary renal neoplasms submitted to our department between 2003 and 2009 were re-examined. Twenty-three nephrectomy materials from 21 patients had non-neoplastic changes, 2 of which were bilateral. Patient follow-up data were obtained from electronic medical records. Of all cases, eight had diabetic nephropathy; 2, amyloidosis; 5, segmental proliferative and/or sclerotic glomerulonephritis; and 6, cystic renal changes. These findings were seen in 5% of nephrectomy specimens diagnosed as clear cell renal cell carcinoma (RCC), chromophobe cell RCC and oncocytoma, whereas this rate was two times higher in nephrectomy specimens with papillary RCC. Most patients with renal failure who were diagnosed with clear cell carcinoma died within the first two years. Despite limited number of cases in our series, prognosis of cases with clear cell RCC were poorer. Consequently, we think that non-neoplastic changes should be reported along with the details regarding the tumor in order to achieve best treatment planning. (c) 2013 Elsevier Inc. All rights reserved

Factors influencing engraftment in autologous peripheral hematopoetic stem cell transplantation (PBSCT)

WOS: 000245704500005PubMed ID: 17292672Autologous peripheral blood stem cells transplantation (PBSCT) is a therapeutic option which can be used in various hematological neoplastic disorders; and it can prolong disease free survival and total survival and at times it may be curative. In this study, we investigated variables influencing PBSCT in 91 patients who had undergone PBSCT between 1998 and 2002 in our center, retrospectively. PBSC collection was performed after mobilization with G-CSF or chemotherapy plus growth factor. Only high dose chemotherapy was used for conditioning regimes. The median number of CD34+ was 11.5 x 10(6)/kg. Posttransplant neutrophil engraftment (> 500/mu L) was requiring a median of 10 days, it was 13 days for platelet engraftment (> 20,000/mu L). For neutrophil and platelet engraftment, we investigated; sex, age, diagnosis and CD34+ cells, the time interval between diagnosis and transplantation, number of apheresis, conditioning regime, growth factor initiation day as independent variables. In univariate analysis CD34+ cell number (> 10 x 10(6)/kg), time interval more than one year between diagnosis and transplantation and BEAM conditioning was found to be significant for neutrophil engraftment. But in multivariate analysis none of them was found to be significant. For platelet engraftment in univariate analysis CD34+ cell number (> 7 x 10(6)/kg), primary diagnosis of multiple myeloma initiation day of growth factor (> 2 day) was found to be significant. In multivariate analyses only CD34+ cell count was found to be significant (p = 0.005). In conclusion, as in previous studies we found that the only predictor of engraftment kinetics was CD34+ cell count. (c) 2006 Published by Elsevier Ltd