Amelioration of radiation-induced cellular alterations in rats administered with solvent fractions of methanol leaf extracts of Adansonia digitata and Corchorus olitorius

Exposure of rats to radiation results in an increase of free radical level from subtoxic (24 μg/mol) to a toxic concentration (120 μg/mol) in the system of rats. Free radical level above 120 μg/mol, leads to dysregulated Nf-kB and Nrf-2, thus exacerbating oxidative stress and cellular alterations in rats. This study investigated the effects of solvents (n-hexane, ethylacetate and n-butanol) fractions of Adansonia digitata and Corchorus olitorius leaves in radiation-induced Nf-kB and Nrf-2 dysregulation in Cellular System of Rats. A total of 48 rats (198 ± 5.00g) were used in this study and were distributed into 8 groups of 6 each. Group I were fed with rat chow and distilled water only, all other groups were irradiated, such that groups II, III, IV, V, VI, VII, VIII and IX were administered distilled water, n-hexane fractions of A. digitata and C. olitorius, ethylacetate fractions of A. digitata and C. olitorius, n-butanol fractions of A. digitata and C. olitorius and Vitamin-C at 1000 mg/kg body weight respectively. Secondary metabolites screening of A. digitata and C. olitorius revealed the presence of flavonoids, polyphenol, alkaloids, tannins and saponins. irradiation significantly (p<0.05) increased Nf-kB, alkaline phosphatase (ALP), alanine transaminase (ALT) and significantly (p<0.05) reduced Nrf-2 and antioxidant capacity. Administration of solvents fractions at 1000 mg/kg bwt significantly (p<0.05) reduced Nf-kB, ALP, ALT and significantly (p<0.05) increased Nrf-2 and antioxidant capacity of rats in the treated groups, such that, n-butanol fraction is the most effective. Data were analysed using analysis of variance and Duncan multiple range test at p<0.05. n-butanol fractions, can therefore be explored as oral remedy against cellular alterations in rats

An empirical analysis on customers’ acceptance of Islamic micro finance in Kano State, North Western-Nigeria : the moderating effect of awareness

Purpose: The objective of this research paper is to conceptualize the model in examining the moderating effect of awareness on attitude, knowledge, and customers’ acceptance of Islamic micro finance in Kano State, North Western-Nigeria. As, Islamic micro financial institutions deliver loans to small and medium enterprises (SMEs). Since, it serves as a means of curving of some social vices such as poverty, ethno-religious crises, farmers and herdsmen crises, cattle rustling, arm rubbers and kidnappers among others. Despite it great contributions to the growth of the economy there is deprived awareness on Islamic micro finance which leads to inadequate investment and patronage by the people in Kano State. Investors and the general public can use this research for guidance towards investments of their capital into Islamic micro finance for maximum profits. Also, stake holders, SMEs, traders and farmers can utilize the outcome of this study. Similarly, stock exchange commission, Central Bank of Nigeria and other financial institutions can use the results of this study towards making policies and strategies. -- Design/methodology/approach: Questionnaire was used and data was collected by random sample of 400 selected Islamic micro finance customers in Kano state, Nigeria. PLSSEM was used in analysing and testing the formulated hypotheses. -- Findings: Result indicated that knowledge and attitude have positive and significant relationship on acceptance of Islamic micro finance, while, awareness did not moderate relationship between attitudes but moderates knowledge and acceptance of Islamic micro finance.peer-reviewe

Development of Bench Scale Water Treatment Unit for the Treatment of Medium Turbid Water: The Use of Natural Coagulant

Water purification is a process used to enhance water quality and make it more acceptable for specific end-use. The rising increase for portable drinking water has made natural coagulant application for water purification a welcome development. Most reported researches were on the use of natural coagulants in a laboratory batch scale. Because of those above, a bench-scale laboratory study was carried out on the application of Balanites Aegyptiaca seed as a natural coagulant. The outcome showed its usefulness toward water purification. This paper reported the developed bench-scale water treatment plant's performance utilising Balanites Aegyptiaca seed stock solution and the powdered kennel as bio-coagulant. Some design equations were adopted. The treatment units considered include coagulation/flocculation, sedimentation, and filtration. The total tank design capacity was 20 litres with the overflow area's actual size for sedimentation of 7.46 litres. 0.5 Hp electric motor with a speed of 600 rpm and a speed gear drop of 120 rpm were selected. 0.0127 m pipe flow line diameter connecting the tanks with a corresponding pipe flow velocity of 0.108 m/s was obtained from the design. However, in both the coagulation, sedimentation and filtration units, the material balance obtained showed a steadiness in the material flow across sedimentation and filtration units. However, among the parameters tested in the raw turbid water, the turbid water revealed turbidity of 514 NTU, the colour of 5600 CTU, the conductivity of 276 µs/cm, pH of 7.10 and total coliform bacteria count of 85 CFU/100 mL which were above the recommended set standard of WHO and NIS. The result of the treated water using the stock solution and the powdered kennel (bio-coagulant) on the developed water treatment unit showed a remarkable reduction in the tested parameters in the raw turbid water used for the treatment process. Total coliform count reduces from 85 CFU/100 ml to 10 CFU/ml in both cases. It was observed that conductivity increases after the treatment, but other inorganic constituents reduce significantly though not to WHO and NIS's recommended set standard. The 0-dosage treatment conducted also showed a reduction in all the tested parameters

Rural Households’ Attitude to Diversification into Non-farm Enterprises in Katsina State, Nigeria

The study investigated the rural households’ attitude to diversification into non-farm enterprises in Katsina State, Nigeria. A multistage sampling procedure was used to select 256 farmers for the study. Data were obtained with the aid of questionnaire and analyzed using percentage and regression analysis. The most positive attitude was “that non-farm enterprise is a crucial pathway to food security for rural households”.  It was closely followed by “non-farm enterprise is a source of agricultural household savings used for food purchase in hard times” and “non-farm enterprise provides a means to cope or survive when farming fails”. Farmers expressed positive attitude to diversification into non-farm enterprises and do not depend on agriculture as a sole means of livelihood but diversified income sources; the diversified farmers had higher income level. Government should support the existing non-farm enterprises and encourage creation of new ones; also improve formal credit access. Furthermore, technical support and skills acquisition training programs should be provided to enhance the performance and efficiency of non-farm enterprises in rural areas

Rural Households’ Attitude to Diversification into Non-farm Enterprises in Katsina State, Nigeria

The study investigated the rural households’ attitude to diversification into non-farm enterprises in Katsina State, Nigeria. A multistage sampling procedure was used to select 256 farmers for the study. Data were obtained with the aid of questionnaire and analyzed using percentage and regression analysis. The most positive attitude was “that non-farm enterprise is a crucial pathway to food security for rural households”.  It was closely followed by “non-farm enterprise is a source of agricultural household savings used for food purchase in hard times” and “non-farm enterprise provides a means to cope or survive when farming fails”. Farmers expressed positive attitude to diversification into non-farm enterprises and do not depend on agriculture as a sole means of livelihood but diversified income sources; the diversified farmers had higher income level. Government should support the existing non-farm enterprises and encourage creation of new ones; also improve formal credit access. Furthermore, technical support and skills acquisition training programs should be provided to enhance the performance and efficiency of non-farm enterprises in rural areas

Rural Households’ Attitude to Diversification into Non-farm Enterprises in Katsina State, Nigeria

The study investigated the rural households’ attitude to diversification into non-farm enterprises in Katsina State, Nigeria. A multistage sampling procedure was used to select 256 farmers for the study. Data were obtained with the aid of questionnaire and analyzed using percentage and regression analysis. The most positive attitude was “that non-farm enterprise is a crucial pathway to food security for rural households”.  It was closely followed by “non-farm enterprise is a source of agricultural household savings used for food purchase in hard times” and “non-farm enterprise provides a means to cope or survive when farming fails”. Farmers expressed positive attitude to diversification into non-farm enterprises and do not depend on agriculture as a sole means of livelihood but diversified income sources; the diversified farmers had higher income level. Government should support the existing non-farm enterprises and encourage creation of new ones; also improve formal credit access. Furthermore, technical support and skills acquisition training programs should be provided to enhance the performance and efficiency of non-farm enterprises in rural areas

Global economic burden of unmet surgical need for appendicitis

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe