N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.PostprintPostprintPeer reviewe

Use of recycled aluminum - polyethylene composite films as anodic electrodes for electrocoagulation of wastewater

artículo para uso de películas de aluminio polietilenoThis work evaluates the use of aluminum contained in the aluminum-polyethylene films as anodic electrodes using the electrocoagulation technique to reduce the pollutants contents of an industrial wastewater quickly and effectively. Two different current densities were applied 25 and 12.5 mA cm-2. When the current density of 25 mA cm-2 is used, the aluminum electrodes reduce the COD of wastewater by about 65% and the aluminum-polyethylene films electrodes reduces the COD by 56%. The color and turbidity reductions are 87 and 90% respectively. The use of aluminum-polyethylene films as electrodes in the electrocoagulation process contributes to the pollutant removal without the addition of chemical reagents or changing the pH, so it is both effective and environmentally friendly.Centro Conjunto de Investigación en Química Sustentable, UAEM-UNAM, CONACYT, UAEMe

Water consumption and preliminary crop coefficients of two Populus ×canadensis clones (‘I-214’ and ‘I-488’) grown at low planting density

Aim of study: The productivity of poplar plantations in Mediterranean climates might be reduced due to lower precipitations in a climate change scenario. Therefore, understanding the water consumption in these plantations is essential for their management. The objective of this study was to estimate water consumption and preliminary crop coefficients (kc) of two universally used poplar clones (Populus x Canadensis ‘I-214’ and ‘I-488’).Area of study: Central Chile (36º 05 'LS; 72º 47' LW; 470 m.a.s.l.).Materials and methods: Commercial stands of poplar clones established in 2009 and 2010 at low density (6×6 m) were used to experiment during the 2016-2017 growing season. In each of them, water balance was measuring, by determining evaporation using micro lysimeters and transpiration using the sap flow. Additionally, the water status and the leaf area index (LAI) were measured to understand the behaviour of both clones.Main results: Although the water supplied to both clones was the same, the transpiration (T) was higher for ‘I-488’ than ‘I-214’, at those moments in which the evapotranspiration (ETr) and the vapour pressure deficit (VPD) was higher. On the other hand, differences were observed in plant water status, ‘I-488’ had more negative xilematic water potential (Ψx) compared to ‘I-214’. In turn, I-214 proved to have a higher Leaf Area Index (LAI) than I-488 and grew more during the season, refuting its greater efficiency.Research highlights: These results allow characterizing the water behaviour of both clones in Mediterranean climate condition, but it is necessary to extend the study to more seasons and different age ranges.Keywords: Crop coefficient; water consumption; water balance; poplar

DESARROLLO DE UN SOFTWARE DESDE TERAPIA OCUPACIONAL PARA VALORACIÓN DE HABILIDADES PERCEPTIVO-COGNITIVAS, OBTENIENDO UN CONCEPTO OCUPACIONAL Y PLAN DE ACCIÓN INMEDIATO, EN NIÑOS DE 6 A 10 AÑOS EN EDAD ESCOLAR DEL INSTITUTO SALESIANO SAN JUAN BOSCO.

Este proyecto de investigación buscó desarrollar un software desde Terapia Ocupacional para valorar las habilidades perceptivo cognitivas, en niños de 6 a 10 años en edad escolar, que son las destrezas necesarias para el desempeño ocupacional en la escuela, para esto se recopilaron 14 pruebas de 2 baterías estandarizadas; 8 subpruebas del DTVP-2 “Método de la evaluación de la percepción visual de Marianne Frostig”; y 6 subpruebas de la ENI “Evaluación Neuropsicológica Infantil”, con las cuales se elabora un protocolo de valoración el cual lleva por nombre SVH-E “software de valoración de habilidades escolares”, una herramienta interactiva que se implementa a través de una tablet electrónica, donde el niño interactúa directamente con una aplicación lúdica, que paralelamente evalúa al menor sin que él lo detecte; esta aplicación nos arrojara una tabla de calificación de las áreas ya mencionadas, un concepto ocupacional y el plan de acción para la prevención de futuros problemas de aprendizaje. Siendo el fin último disminuir el tiempo requerido en el proceso de valoración; haciéndolo más rápido, ágil, verás y atractivo; evitando tener un proceso extenuante, abrumador, agotador y repetitivo. Para la validación de este proceso se realizo la aplicación de pruebas piloto en el Instituto Salesiano san Juan Bosco, con una muestras base de 89 escolares, identificación los beneficios y falencias del proceso realizado, e identificando las habilidades y/o falencias, según edad cronológica, escolaridad y genero

High prognostic value of measurable residual disease detection by flow cytometry in chronic lymphocytic leukemia patients treated with front-line fludarabine, cyclophosphamide, and rituximab, followed by three years of rituximab maintenance

It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. In this study, we analyzed the outcome of 84 patients at 3 years of follow-up after first-line treatment with fludarabine, cyclophosphamide and rituximab (FCR) induction followed by 36 months of rituximab maintenance thearpy. MRD was assessed by a quantitative four-color flow cytometry panel with a sensitivity level of 10-4. Eighty out of 84 evaluable patients (95.2%) achieved at least a partial response or better at the end of induction. After clinical evaluation, 74 patients went into rituximab maintenance and the primary endpoint was assessed in the final analysis at 3 years of follow-up. Bone marrow (BM) MRD analysis was performed after the last planned induction course and every 6 months in cases with detectable residual disease during the 36 months of maintenance therapy. Thirty-seven patients (44%) did not have detectable residual disease in the BM prior to maintenance therapy. Interestingly, 29 patients with detectable residual disease in the BM after induction no longer had detectable disease in the BM following maintenance therapy. After a median followup of 6.30 years, the median overall survival (OS) and PFS had not been reached in patients with either undetectable or detectable residual disease in the BM, who had achieved a complete response at the time of starting maintenance therapy. Interestingly, univariate analysis showed that after rituximab maintenance OS was not affected by IGHV status (mutated vs. unmutated OS: 85.7% alive at 7.2 years vs. 79.6% alive at 7.3 years, respectively). As per protocol, 15 patients (17.8%), who achieved a complete response and undetectable peripheral blood and BM residual disease after four courses of induction, were allowed to stop fludarabine and cyclophosphamide and complete two additional courses of rituximab and continue with maintenance therapy for 18 cycles. Surprisingly, the outcome in this population was similar to that observed in patients who received the full six cycles of the induction regimen. These data show that, compared to historic controls, patients treated with FCR followed by rituximab maintenance have high-quality responses with fewer relapses and improved OS. The tolerability of this regime is favorable. Furthermore, attaining an early undetectable residual disease status could shorten the duration of chemoimmunotherapy, reducing toxicities and preventing long-term side effects. The analysis of BM MRD after fludarabine-based induction could be a powerful predictor of post-maintenance outcomes in patients with CLL undergoing rituximab maintenance and could be a valuable tool to identify patients at high risk of relapse, influencing further treatment strategies

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Marejadas rurales y luchas por la vida, vol. iv: permanencias, resistencias y luchas por la vida

Volumen 4. Permanencias, resistencias y luchas por la vida, coordinado por: Elisabeth A. Mager Hois, Miguel Ángel Paz Frayre y Carla Zamora Lomelí, integra 15 capítulos y está dividido en tres secciones, la primera denominada Permanencia, contiene 5 capítulos que intentan establecer como eje común la lucha continua en las comunidades campesinas para continuar con la vida rural. La segunda, Identidad y resistencia, está compuesta por 4 capítulos que reflexionan sobre varios procesos de resistencia de la vida rural ante los cambios globales e internos en su propio proceso de vida, otros trabajos intentan encontrar aquellos elementos que generan y mantienen alguna forma de identidad, y la tercera sección, Lucha por la vida, contiene 6 trabajos que demuestran todas aquellas posibilidades que existen en el medio rural para sostenerse y mantenerse, generando diferentes formas y estrategias que los une en la continua lucha por vivir con pocas pretensiones y con difíciles perspectivas pero siempre encontrando alternativas.ASOCIACIÓN MEXICANA DE ESTUDIOS RURALES, INSTITUTO DE CIENCIAS AGROPECUARIAS Y RURALES (ICAR), UNIVERSIDAD DE GUADALAJARA, FACULTAD DE ESTUDIOS SUPERIORES ACATLÁN-UNAM, ECOSUR, CUCOSTA SUR GRANA, EL COLEGIO DE MICHOACÁN A.C., UNIVERSIDAD MICHOACANA DE SAN NICOLAS HIDALG