Near-infrared interferometric observation of the Herbig Ae star HD144432 with VLTI/AMBER

We study the sub-AU-scale circumstellar environment of the Herbig Ae star HD144432 with near-infrared (NIR) VLTI/AMBER observations to investigate the structure of its inner dust disk. The interferometric observations were carried out with the AMBER instrument in the H and K band. We interpret the measured H- and K-band visibilities, the near- and mid-infrared visibilities from the literature, and the SED of HD144432 by using geometric ring models and ring-shaped temperature-gradient disk models with power-law temperature distributions. We derived a K-band ring-fit radius of 0.17 \pm 0.01 AU and an H-band radius of 0.18 \pm 0.01 AU (for a distance of 145 pc). This measured K-band radius of \sim0.17 AU lies in the range between the dust sublimation radius of \sim0.13 AU (predicted for a dust sublimation temperature of 1500 K and gray dust) and the prediction of models including backwarming (\sim0.27 AU). We found that an additional extended halo component is required in both the geometric and temperature-gradient modeling. In the best temperature- gradient model, the disk consists of two components. The inner part of the disk is a thin ring with an inner radius of \sim0.21 AU, a temperature of \sim1600 K, and a ring thickness \sim0.02 AU. The outer part extends from \sim1 AU to \sim10 AU with an inner temperature of \sim400 K. We find that the disk is nearly face-on with an inclination angle of < 28 degree. Our temperature-gradient modeling suggests that the NIR excess is dominated by emission from a narrow, bright rim located at the dust sublimation radius, while an extended halo component contributes \sim6% to the total flux at 2 {\mu}m. The MIR model emission has a two-component structure with \sim20% flux from the inner ring and the rest from the outer part. This two-component structure suggests a disk gap, which is possibly caused by the shadow of a puffed-up inner rim.Comment: 7 pages, 5 figures, accepted by A&

Replication study of SNP associations for colorectal cancer in Hong Kong Chinese

BACKGROUND: Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC. METHODS: An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs. RESULTS: Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs4779584 on 15q14 and rs12953717 on 18q21.2. There was significant linear association between CRC risk and the number of independent risk variants possessed by an individual (P=2.29 × 10(-5)). CONCLUSION: These results indicate that some previously reported SNP associations also impact on CRC risk in the Chinese population. Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations. Our results suggest that many associations for CRC are likely to generalise across populations

CAST constraints on the axion-electron coupling

In non-hadronic axion models, which have a tree-level axion-electron interaction, the Sun produces a strong axion flux by bremsstrahlung, Compton scattering, and axio-recombination, the "BCA processes." Based on a new calculation of this flux, including for the first time axio-recombination, we derive limits on the axion-electron Yukawa coupling g_ae and axion-photon interaction strength g_ag using the CAST phase-I data (vacuum phase). For m_a < 10 meV/c2 we find g_ag x g_ae< 8.1 x 10^-23 GeV^-1 at 95% CL. We stress that a next-generation axion helioscope such as the proposed IAXO could push this sensitivity into a range beyond stellar energy-loss limits and test the hypothesis that white-dwarf cooling is dominated by axion emission

Processing of Thionin Precursors in Barley Leaves by a Vacuolar Proteinase

Thionins are synthesized as precursors with a signal peptide and a long C-terminal acidic peptide that is post-translationally processed. A fusion protein including the maltose-binding protein from Eschrrichia coli (MalE), thionin DG3 froin barley leaves, and its acidic C-terminal peptide has been used to obtain antibodies that recognize both domains of the precursor. In barley leaf sections. mature thionins accuinulated in the vacuolar content, while the acidic peptide was not detected in any cell fraction. Brefeldin A and inonensin inhibited processing of the precursor but its export from the microsomal fraction was not inhibited. Both purified vacuoles aiid an acid (pH 5.5) extract from leaves processed the fusion protein into a MalE-thionin and an acidic peptide fragment. A 70-kDa proteinase that effected this cleavage was purified froin the acid extract. Processing of the fusion protein by both lysed vacuoles and the purified proteinase was inhibited by Zn2+ and by Cu2+, but not by inhibitors of the previously described vacuolar processing thiol or aspartic proteinases. In vivo processing of the thionin precursor in leaf sections was also inhibited by Zn+, and Cu2+, Variants of the fusion protein with altered processing sites that represented thme of thionin precursors from different taxa were readily processed by the proteinase, whereas changing the polarity of either the C-terminal or N-terminal residues of the processing site prevented cleavage by the proteinase

Star and protoplanetary disk properties in Orion's suburbs

(Note: this is a shortened version of the original "structured" A&A format abstract.) We performed a large optical spectroscopic and photometric survey of the Lynds~1630N and 1641 clouds. We provide a catalog of 132 confirmed young stars in L1630N and 267 such objects in L1641. We identify 28 transition disk systems, 20 of which were previously unknown, as well as 42 new transition disk candidates for which we have broad-band photometry but no optical spectroscopy. We estimate mass accretion rates M_acc from the equivalent widths of the H_alpha, H_beta, and HeI 5876\AA emission lines, and find a dependence on stellar mass of M_acc propto Mstar^alpha, with alpha~3.1 in the subsolar mass range that we probe. An investigation of a large literature sample of mass accretion rate estimates yields a similar slope of alpha~2.8 in the subsolar regime, but a shallower slope of alpha~2.0 if the whole mass range of 0.04 M_sun-5 Msun is included. Among the transition disk objects, the fraction of stars that show significant accretion activity is relatively low compared to stars with still optically thick disks (26\pm11% vs. 57\pm6%, respectively). However, those transition disks that do show significant accretion have the same median accretion rate as normal optically thick disks of 3-4*10^{-9} M_sun/yr. We find that the ages of the transition disks and the WTTSs without disks are statistically indistinguishable, and both groups are significantly older than the CTTSs. These results argue against disk-binary interaction or gravitational instability as mechanisms causing a transition disk appearance. Our observations indicate that disk lifetimes in the clustered population are shorter than in the distributed population. We propose refined Halpha equivalent width criteria to distinguish WTTSs from CTTSs.Comment: 52 pages, 16 tables, 29 figures. Accepted by A&A. Table numbering error correcte

bioNMF: a versatile tool for non-negative matrix factorization in biology

BACKGROUND: In the Bioinformatics field, a great deal of interest has been given to Non-negative matrix factorization technique (NMF), due to its capability of providing new insights and relevant information about the complex latent relationships in experimental data sets. This method, and some of its variants, has been successfully applied to gene expression, sequence analysis, functional characterization of genes and text mining. Even if the interest on this technique by the bioinformatics community has been increased during the last few years, there are not many available simple standalone tools to specifically perform these types of data analysis in an integrated environment. RESULTS: In this work we propose a versatile and user-friendly tool that implements the NMF methodology in different analysis contexts to support some of the most important reported applications of this new methodology. This includes clustering and biclustering gene expression data, protein sequence analysis, text mining of biomedical literature and sample classification using gene expression. The tool, which is named bioNMF, also contains a user-friendly graphical interface to explore results in an interactive manner and facilitate in this way the exploratory data analysis process. CONCLUSION: bioNMF is a standalone versatile application which does not require any special installation or libraries. It can be used for most of the multiple applications proposed in the bioinformatics field or to support new research using this method. This tool is publicly available at

Les Houches 2015: Physics at TeV colliders - new physics working group report

We present the activities of the 'New Physics' working group for the 'Physics at TeV Colliders' workshop (Les Houches, France, 1-19 June, 2015). Our report includes new physics studies connected with the Higgs boson and its properties, direct search strategies, reinterpretation of the LHC results in the building of viable models and new computational tool developments. Important signatures for searches for natural new physics at the LHC and new assessments of the interplay between direct dark matter searches and the LHC are also considered.Comment: Proceedings of the New Physics Working Group of the 2015 Les Houches Workshop, Physics at TeV Colliders, Les Houches 1-19 June 2015. 197 page

Methamphetamine withdrawal induces activation of CRF neurons in the brain stress system in parallel with an increased activity of cardiac sympathetic pathways.

Methamphetamine (METH) addiction is a major public health problem in some countries. There is evidence to suggest that METH use is associated with increased risk of developing cardiovascular problems. Here, we investigated the effects of chronic METH administration and withdrawal on the activation of the brain stress system and cardiac sympathetic pathways. Mice were treated with METH (2 mg/kg, i.p.) for 10 days and left to spontaneous withdraw for 7 days. The number of corticotrophin-releasing factor (CRF), c-Fos, and CRF/c-Fos neurons was measured by immunohistochemistry in the paraventricular nucleus of the hypothalamus (PVN) and the oval region of the bed nucleus of stria terminalis (ovBNST), two regions associated with cardiac sympathetic control. In parallel, levels of catechol-o-methyl-transferase (COMT), tyrosine hydroxylase (TH), and heat shock protein 27 (Hsp27) were measured in the heart. In the brain, chronic-METH treatment enhanced the number of c-Fos neurons and the CRF neurons with c-Fos signal (CRF+/c-Fos+) in PVN and ovBNST. METH withdrawal increased the number of CRF+neurons. In the heart, METH administration induced an increase in soluble (S)-COMT and membrane-bound (MB)-COMT without changes in phospho (p)-TH, Hsp27, or pHsp27. Similarly, METH withdrawal increased the expression of S- and MB-COMT. In contrast to chronic treatment, METH withdrawal enhanced levels of (p)TH and (p)Hsp27 in the heart. Overall, our results demonstrate that chronic METH administration and withdrawal activate the brain CRF systems associated with the heart sympathetic control and point towards a METH withdrawal induced activation of sympathetic pathways in the heart. Our findings provide further insight in the mechanism underlining the cardiovascular risk associated with METH use and proposes targets for its treatment