Histopathologic and immunohistochemical investigations of dental abscess formed in maxillofacial area

Background: An abscess is a pocket of pus that forms around the root of an infected tooth. In this study, we aimed to investigate the extracellular matrix proteases ADAMTS1, ADAMTS4, osteonectin, and osteopontin expressions in abscess fluid cells in jaws after implantation and prosthesis operation. Materials and methods: In this clinical study, abscess fluids belonging to 17 patients who applied to the Department of Oral and Maxillofacial Surgery were examined histopathologically and immunohistochemically. In the histopathological examination of the abscess fluid, separation of chromatin bridges in the nuclei of neutrophil cells, pyknosis and apoptotic changes in the nucleus, degenerative change in the cytoplasm, and occasional vacuolar structures were observed. Results: The positive reaction of ADAMTS1 was observed in fibroblast cells, plasma cells, and macrophage cells. The positive reaction of ADAMTS4 was observed in fibroblast cells, osteoclast cells, and some apoptotic leukocyte cells. Osteopontin expression in osteoclastic cells and polymorphonuclear cells was defined as positive. Osteonectin expression was positive in polymorphonuclear leukocytes and hypertrophic fibroblast cells. Conclusions: ADAMTS1 and ADAMTS4 may induce bone destruction with its distinctive property in alveolar bone resorption, which promotes the activation of osteoclasts, which can accelerate the destruction of the extracellular matrix in the acute phase. Furthermore, osteoclastic activity increased with the increase of osteonectin and osteopontin protein expression due to inflammation in the abscess cases

Palaeozoic-Recent geological development and uplift of the Amanos Mountains (S Turkey) in the critically located northwesternmost corner of the Arabian continent

<p>We have carried out a several-year-long study of the Amanos Mountains, on the basis of which we present new sedimentary and structural evidence, which we combine with existing data, to produce the first comprehensive synthesis in the regional geological setting. The ca. N-S-trending Amanos Mountains are located at the northwesternmost edge of the Arabian plate, near the intersection of the African and Eurasian plates. Mixed siliciclastic-carbonate sediments accumulated on the north-Gondwana margin during the Palaeozoic. Triassic rift-related sedimentation was followed by platform carbonate deposition during Jurassic-Cretaceous. Late Cretaceous was characterised by platform collapse and southward emplacement of melanges and a supra-subduction zone ophiolite. Latest Cretaceous transgressive shallow-water carbonates gave way to deeper-water deposits during Palaeocene-Eocene. Eocene southward compression, reflecting initial collision, resulted in open folding, reverse faulting and duplexing. Fluvial, lagoonal and shallow-marine carbonates accumulated during Late Oligocene(?)-Early Miocene, associated with basaltic magmatism. Intensifying collision during Mid-Miocene initiated a foreland basin that then infilled with deep-water siliciclastic gravity flows. Late Miocene-Early Pliocene compression created mountain-sized folds and thrusts, verging E in the north but SE in the south. The resulting surface uplift triggered deposition of huge alluvial outwash fans in the west. Smaller alluvial fans formed along both mountain flanks during the Pleistocene after major surface uplift ended. Pliocene-Pleistocene alluvium was tilted towards the mountain front in the west. Strike-slip/transtension along the East Anatolian Transform Fault and localised sub-horizontal Quaternary basaltic volcanism in the region reflect regional transtension during Late Pliocene-Pleistocene (<4 Ma).</p

Looking for timing variations in the transits of 16 exoplanets

We update the ephemerides of 16 transiting exoplanets using our ground-based observations, new Transiting Exoplanet Survey Satellite data, and previously published observations including those of amateur astronomers. All these light curves were modelled by making use of a set of quantitative criteria with the exofast code to obtain mid-transit times. We searched for statistically significant secular and/or periodic trends in the mid-transit times. We found that the timing data are well modelled by a linear ephemeris for all systems except for XO-2 b, for which we detect an orbital decay with the rate of -12.95 +/- 1.85 ms yr(-1) that can be confirmed with future observations. We also detect a hint of potential periodic variations in the transit timing variation data of HAT-P-13 b, which also requires confirmation with further precise observations

Absolute dimensions of solar-type eclipsing binaries : NY Hya: a test for magnetic stellar evolution models

Funding: Europlanet 2024 RI has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 871149. N.P.’s work was supported by Fundação para a Ciência e a Tecnologia (FCT) through the research grants UIDB/04434/2020 and UIDP/04434/2020. U.G.J. acknowledges funding from the Novo Nordisk Foundation Interdisciplinary Synergy Programme grant no. NNF19OC0057374 and from the European Union H2020-MSCA-ITN-2019 under Grant no. 860470 (CHAMELEON). J.V. acknowledges support from the Grant Agency of the Czech Republic (GACR 22-34467S). J.C.M. acknowledges financial support by Spanish grants PID2021-125627OBC31 funded by MCIU/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, PGC2018-098153-B-C33 funded by MCIU/AEI, by the programme Unidad de Excelencia María de Maeztu CEX2020-001058-M, and by the Generalitat de Catalunya/CERCA programme. P.L.P. was partly funded by Programa de Iniciación en Investigación-Universidad de Antofagasta. INI-17-03.The binary star NY Hya is a bright, detached, double-lined eclipsing system with an orbital period of just under five days with two components each nearly identical to the Sun and located in the solar neighbourhood. The objective of this study is to test and confront various stellar evolution models for solar-type stars based on accurate measurements of stellar mass and radius. We present new ground-based spectroscopic and photometric as well as high-precision space-based photometric and astrometric data from which we derive orbital as well as physical properties of the components via the method of least-squares minimisation based on a standard binary model valid for two detached components. Classic statistical techniques were invoked to test the significance of model parameters. Additional empirical evidence was compiled from the public domain; the derived system properties were compared with archival broad-band photometry data enabling a measurement of the system's spectral energy distribution that allowed an independent estimate of stellar properties. We also utilised semi-empirical calibration methods to derive atmospheric properties from Str\"{o}mgren photometry and related colour indices. Data was used to confront the observed physical properties with classic and magnetic stellar evolution models.Peer reviewe

The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia.

RATIONALE: The NEWMEDS initiative (Novel Methods leading to New Medications in Depression and Schizophrenia, http://www.newmeds-europe.com ) is a large industrial-academic collaborative project aimed at developing new methods for drug discovery for schizophrenia. As part of this project, Work package 2 (WP02) has developed and validated a comprehensive battery of novel touchscreen tasks for rats and mice for assessing cognitive domains relevant to schizophrenia. OBJECTIVES: This article provides a review of the touchscreen battery of tasks for rats and mice for assessing cognitive domains relevant to schizophrenia and highlights validation data presented in several primary articles in this issue and elsewhere. METHODS: The battery consists of the five-choice serial reaction time task and a novel rodent continuous performance task for measuring attention, a three-stimulus visual reversal and the serial visual reversal task for measuring cognitive flexibility, novel non-matching to sample-based tasks for measuring spatial working memory and paired-associates learning for measuring long-term memory. RESULTS: The rodent (i.e. both rats and mice) touchscreen operant chamber and battery has high translational value across species due to its emphasis on construct as well as face validity. In addition, it offers cognitive profiling of models of diseases with cognitive symptoms (not limited to schizophrenia) through a battery approach, whereby multiple cognitive constructs can be measured using the same apparatus, enabling comparisons of performance across tasks. CONCLUSION: This battery of tests constitutes an extensive tool package for both model characterisation and pre-clinical drug discovery.This work was supported by the Innovative Medicine Initiative Joint Undertaking under grant agreement no. 115008 of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013). The authors thank Charlotte Oomen for valuable comments on the manuscript.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s00213-015-4007-

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Collider aspects of flavour physics at high Q

This review presents flavour related issues in the production and decays of heavy states at LHC, both from the experimental side and from the theoretical side. We review top quark physics and discuss flavour aspects of several extensions of the Standard Model, such as supersymmetry, little Higgs model or models with extra dimensions. This includes discovery aspects as well as measurement of several properties of these heavy states. We also present public available computational tools related to this topic.Comment: Report of Working Group 1 of the CERN Workshop ``Flavour in the era of the LHC'', Geneva, Switzerland, November 2005 -- March 200

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd