Riesgo de sarcopenia en ancianas con queja de dolor lumbar agudo

Verificou-se o risco de sarcopenia em idosas comunitárias com queixa de dor lombar aguda e comparouse o índice de dor e mobilidade/equilíbrio entre aquelas em risco de sarcopenia e as não sarcopênicas. Pesquisa transversal, subprojeto do estudo epidemiológico e multicêntrico Back Complaints in the Elders (Bace). Participaram idosas com ao menos um episódio de dor lombar aguda no prazo de seis semanas antes da coleta de dados. Avaliou-se a velocidade de marcha (4,6m), a força de preensão palmar (dinamômetro Jamar), o índice de dor (escala analógica de dor) e mobilidade/equilíbrio (Timed Up and Go test). O risco de sarcopenia foi estimado por medida percentual e as comparações pelo teste t para amostras independentes; o nível de significância adotado foi de 5%. Participaram deste estudo 322 idosas: o risco de sarcopenia foi de 54%, ou seja, 173 idosas (71,8±5,2 anos) estavam em risco de sarcopenia e 149 (46%) eram não sarcopênicas (71,5±5,1 anos). Houve diferença quanto à intensidade da dor (p=0,02) e à mobilidade/ao equilíbrio (p=0,01), sendo que aquelas em risco de sarcopenia estavam em piores condições. Os resultados demonstraram risco de sarcopenia entre as idosas com dor lombar aguda. Estas apresentavam maior índice de dor e pior mobilidade/equilíbrio, sugerindo que a sarcopenia, se presente em idosas com essa dor, pode influenciar negativamente na funcionalidade.Se verificó el riesgo de sarcopenia en ancianas comunitarias con queja de dolor lumbar agudo y se comparó el índice de dolor y movilidad/equilibrio entre aquellas en riesgo de sarcopenia y las no sarcopénicas. Investigación transversal, subproyecto del estudio epidemiológico y multicéntrico Back Complaints in the Elders (Bace). Participaron ancianas con al menos un episodio de dolor lumbar agudo hasta seis semanas antes de la recolección de datos. Se evaluó la velocidad de marcha (4,6m), la fuerza de asimiento palmar (dinamómetro Jamar), el índice de dolor (escala analógica de dolor) y movilidad/equilibrio (Timed Up and Go test). El riesgo de sarcopenia fue estimado por medida porcentual y las comparaciones por la prueba t para muestras independientes; el nivel de significancia adoptado fue del 5%. El estudio incluyó a 322 ancianas: el riesgo de sarcopenia fue del 54%, o sea, 173 ancianas (71,8 ± 5,2 años) estaban en riesgo de sarcopenia, y 149 (46%) fueron sarcopénicas (71,5 ± 5,1 años). Se observó una diferencia en cuanto a la intensidad del dolor (p=0,02) y a la movilidad/al equilibrio (p=0,01), siendo que aquellas en riesgo de sarcopenia estaban en peores condiciones. Los resultados demostraron el riesgo de sarcopenia entre ancianas con dolor lumbar agudo. Estas presentaban mayor índice de dolor y peor movilidad/equilibrio, sugiriendo que la sarcopenia, si está presente en ancianas con ese dolor, puede influenciar negativamente en la funcionalidad. Palabras clave |The risk of sarcopenia was verified in community-dwelling older women with complaints of acute low back pain. The pain index and mobility/balance were compared between patients at risk of sarcopenia and the non-sarcopenic ones. This is a cross-sectional research, subproject of the epidemiological and multicenter study Back Complaints in the Elders (BACE). patients were older women with at least one episode of acute low back pain within six weeks prior to data collection. We evaluated the walking speed (4.6 m), grip strength (Jamar dynamometer), pain index (analog pain scale) and mobility/balance (Timed Up and Go test). Risk of sarcopenia was estimated by percentage measure and comparisons by the Independent Samples t Test. A significance level of 5% was adopted. A total of 322 older women participated in this study. The risk of sarcopenia was 54%, i.e., 173 patients (71.8±5.2 years) were at risk of sarcopenia and 149 (46%) were non-sarcopenic (71.5±5.1 years). There was difference for the pain intensity (p=0.02) and the mobility/balance (p=0.01), given that the ones at risk of sarcopenia were in worse conditions. The results showed risk of sarcopenia among older women with acute low back pain. The latter showed higher pain index and worse mobility/balance, suggesting that sarcopenia, if present in older women with this pain, can influence negatively the functionalit

Efeitos do brinquedo terapêutico em serviços hospitalares pediátricos / Effects of therapeutic toy in pediatric hospital services

O seguinte estudo tem como objetivo descrever os efeitos do brinquedo terapêutico em serviços hospitalares pediátricos. Trata-se de uma revisão integrativa da literatura, de abordagem qualitativa, de natureza exploratória e descritiva. A elaboração da pergunta norteadora ocorreu fazendo uso do acrônimo PICo (população, interesse e contexto), sendo P (pediatria), I (uso de brinquedo terapêutico) e C (emergências e urgências), o que gerou na seguinte indagação: Como se dá a utilização do brinquedo terapêutico nos serviços de emergências e urgências pediátricas? O levantamento nas bases de dados foi efetuado na Medical Literature Analysis and Retrieval System On-line (MEDLINE), por meio da PubMed; Banco de Dados em Enfermagem (BDENF) e Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), por intermédio da Biblioteca Virtual de Saúde (BVS), e a Biblioteca Virtual (Scielo). Os Descritores em Ciências da Saúde (DeCS) utilizados foram: “jogos e brinquedos”, “terapêutica”, "hospitais" e “pediatria”, cruzados entre si pelo operador booleano AND. A utilização do brinquedo terapêutico pode contribuir para explorar os interesses, expectativas e necessidades das crianças. As brincadeiras puderam desenvolver características como controle de situação, autonomia, competição, solidariedade, assim como relação família-paciente. Em virtude do que foi mencionado, percebe-se que crianças podem se beneficiar do brinquedo terapêutico. Nesse sentido, é importante que haja capacitação dos profissionais em relação ao saber usar os brinquedos a fim de promover um atendimento mais leve e humanizado para aquela criança que está em dor e sofrimento

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Os desafios do atendimento de pacientes com sequelas cardiovasculares decorrentes de trauma do tórax / Challenges in the care of patients with cardiovascular sequels resulting from chest trauma

Introdução: O tórax apresenta estruturas de diversos sistemas de sustentação da vida, dentre eles o respiratório e o cardiovascular. Por conter, estruturas nobres para a manutenção da vida, os potenciais para ocorrer lesões graves em decorrência de traumas são muito grandes, como dados mostram, 25% das mortes são secundárias a trauma torácico. Dentro deste contexto, questiona-se quais os desafios no atendimento de pacientes com sequelas cardiovasculares decorrentes de traumas torácicos? Portanto, esse estudo tem como objetivo identificar as dificuldades enfrentadas na assistência de saúde de pacientes com repercussões cardiovasculares devido a trauma de tórax, através da elaboração de um formulário baseado em revisão bibliográfica de dados da literatura científica publicados sobre esse tema. Metodologia: O trabalho baseia-se numa revisão integrativa de literatura, na qual foram analisados artigos publicados em revistas científicas, utilizando-se das bases de dados da BVS (Biblioteca Virtual da Saúde), como: Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) e Scielo (Scientific Electronic Library Online). Resultados: Após as análises e seleção, restaram-se sete artigos para integrar a discussão. Os artigos selecionados, estão descritos na tabela, com autores, título, metodologia, resultados e conclusão. Em seguida, foi realizada uma discussão acerca destes artigos. Conclusão: Cada um dos casos revisados neste estudo demonstra a necessidade e a importância de acompanhamento cuidadoso de todos os pacientes que sofreram trauma torácico fechado, mesmo que a avaliação cardíaca inicial possa ser negativa.