R & D of prototype iTOF-MRPC at CEE

The cooling storage ring (CSR) external-target experiment (CEE) is a spectrometer running at the Heavy Ion Research Facility (HIRFL) at Lanzhou. The CEE is the first large-scale nuclear physics experimental device by China to operate in the fixed-target mode with an energy of 1 GeV. The purpose of the CEE is to study the properties of dense nuclear matter. CEE uses a multi-gap resistive plate chamber (MRPC) as its internal time-of-flight (iTOF) detector for the identification of final-state particles. An iTOF-MRPC prototype with 24 gaps was designed to meet the requirements of CEE, and the readout electronics of the prototype use the FPGA-based time digitization technology. Using cosmic ray tests, the time resolution of the iTOF prototype was found to be approximately 30 ps. In order to further understand how to improve the time resolution of MRPC, ANSYS HFSS was used to simulate the signal transmission process in MRPC. The main factors affecting the timing performance of the MRPC and, accordingly, the optimization scheme are presented.Comment: 11 pages,9 figure

Study of e+e−→ppˉe^+e^- \rightarrow p\bar{p} in the vicinity of ψ(3770)\psi(3770)

Using 2917 $\rm{pb}^{-1}$ of data accumulated at 3.773~$\rm{GeV}$, 44.5~$\rm{pb}^{-1}$ of data accumulated at 3.65~$\rm{GeV}$ and data accumulated during a $\psi(3770)$ line-shape scan with the BESIII detector, the reaction $e^+e^-\rightarrow p\bar{p}$ is studied considering a possible interference between resonant and continuum amplitudes. The cross section of $e^+e^-\rightarrow\psi(3770)\rightarrow p\bar{p}$, $\sigma(e^+e^-\rightarrow\psi(3770)\rightarrow p\bar{p})$, is found to have two solutions, determined to be ($0.059\pm0.032\pm0.012$) pb with the phase angle $\phi = (255.8\pm37.9\pm4.8)^\circ$ ($<$0.11 pb at the 90% confidence level), or $\sigma(e^+e^-\rightarrow\psi(3770)\rightarrow p\bar{p}) = (2.57\pm0.12\pm0.12$) pb with $\phi = (266.9\pm6.1\pm0.9)^\circ$ both of which agree with a destructive interference. Using the obtained cross section of $\psi(3770)\rightarrow p\bar{p}$, the cross section of $p\bar{p}\rightarrow \psi(3770)$, which is useful information for the future PANDA experiment, is estimated to be either ($9.8\pm5.7$) nb ($<17.2$ nb at 90% C.L.) or $(425.6\pm42.9)$ nb

Chimeric aptamers in cancer cell-targeted drug delivery

Aptamers are single-stranded structured oligonucleotides (DNA or RNA) that can bind to a wide range of targets ("apatopes") with high affinity and specificity. These nucleic acid ligands, generated from pools of random-sequence by an in vitro selection process referred to as systematic evolution of ligands by exponential enrichment (SELEX), have now been identified as excellent tools for chemical biology, therapeutic delivery, diagnosis, research, and monitoring therapy in real-time imaging. Today, aptamers represent an interesting class of modern Pharmaceuticals which with their low immunogenic potential mimic extend many of the properties of monoclonal antibodies in diagnostics, research, and therapeutics. More recently, chimeric aptamer approach employing many different possible types of chimerization strategies has generated more stable and efficient chimeric aptamers with aptamer-aptamer, aptamer-nonaptamer biomacromolecules (siRNAs, proteins) and aptamer-nanoparticle chimeras. These chimeric aptamers when conjugated with various biomacromolecules like locked nucleic acid (LNA) to potentiate their stability, biodistribution, and targeting efficiency, have facilitated the accurate targeting in preclinical trials. We developed LNA-aptamer (anti-nucleolin and EpCAM) complexes which were loaded in iron-saturated bovine lactofeerin (Fe-blf)-coated dopamine modified surface of superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs). This complex was used to deliver the specific aptamers in tumor cells in a co-culture model of normal and cancer cells. This review focuses on the chimeric aptamers, currently in development that are likely to find future practical applications in concert with other therapeutic molecules and modalities

Modelling Z → ττ processes in ATLAS with τ-embedded Z → μμ data

This paper describes the concept, technical realisation and validation of a largely data-driven method to model events with Z→ττ decays. In Z→μμ events selected from proton-proton collision data recorded at √s=8 TeV with the ATLAS experiment at the LHC in 2012, the Z decay muons are replaced by τ leptons from simulated Z→ττ decays at the level of reconstructed tracks and calorimeter cells. The τ lepton kinematics are derived from the kinematics of the original muons. Thus, only the well-understood decays of the Z boson and τ leptons as well as the detector response to the τ decay products are obtained from simulation. All other aspects of the event, such as the Z boson and jet kinematics as well as effects from multiple interactions, are given by the actual data. This so-called τ-embedding method is particularly relevant for Higgs boson searches and analyses in ττ final states, where Zarrowττ decays constitute a large irreducible background that cannot be obtained directly from data control samples. In this paper, the relevant concepts are discussed based on the implementation used in the ATLAS Standard Model H→ττ analysis of the full datataset recorded during 2011 and 2012

Experimental investigation into the use of natural rein-forcements for sustainable composite materials

none4noThe present work investigates the manufacturability of different composites reinforced with natural fibres that are hemp and bamboo vinyl. Feasibility of different processes were studied and mechanical properties of obtained composite materials were examined by using non-destructive analysis and tensile tests to assess the manufacturability. Hemp fibres were manufactured by using braiding technology to produce differently oriented textiles. Bamboo reinforcement were employed in form of vinyl sheets. Matrices were made of traditional or innovative polymeric materials. The composite materials were processed through Resin Transfer Moulding (RTM) or Resin Powder Moulding (RPM). Applicability onto different shapes were assessed. The obtained material performances have been compared with both analytical and numerical models to evaluate their applicability. Eventually, results are discussed pointing out foreseen opportunities for the industrial application of investigated materials.mixedDel Borrello, Michele; Secchi, Matteo; Campana, Giampaolo; Mele, MattiaDel Borrello, Michele; Secchi, Matteo; Campana, Giampaolo; Mele, Matti