TransNet: A Transfer Learning-Based Network for Human Action Recognition

Human action recognition (HAR) is a high-level and significant research area in computer vision due to its ubiquitous applications. The main limitations of the current HAR models are their complex structures and lengthy training time. In this paper, we propose a simple yet versatile and effective end-to-end deep learning architecture, coined as TransNet, for HAR. TransNet decomposes the complex 3D-CNNs into 2D- and 1D-CNNs, where the 2D- and 1D-CNN components extract spatial features and temporal patterns in videos, respectively. Benefiting from its concise architecture, TransNet is ideally compatible with any pretrained state-of-the-art 2D-CNN models in other fields, being transferred to serve the HAR task. In other words, it naturally leverages the power and success of transfer learning for HAR, bringing huge advantages in terms of efficiency and effectiveness. Extensive experimental results and the comparison with the state-of-the-art models demonstrate the superior performance of the proposed TransNet in HAR in terms of flexibility, model complexity, training speed and classification accuracy

Physical Therapy Treatment Of A Patient With Chronic Low Back Pain And A Previous History Of A Substance Abuse Disorder: A Case Report

The National Survey on Drug Use and Health (NSDUH) reported that an estimated 27 million people in the United States have reported use of an illicit drug within the past month. Low back pain continues to be a major cause of disability in the United States, with an estimated 70 percent of adults experiencing low back pain at some point during their lifetime. Active exercise programs that include pain education and cognitive behavioral therapy demonstrated significant superior outcome at reducing pain intensity, anxiety/depression, disability, and fear-avoidance compared to therapeutic exercise and manual therapy alone for patients with non-specific chronic low back pain. With both illicit and prescription drug use rising in the US, it is likely clinicians will encounter patients with substance abuse disorders, as well as opiate induced hyperalgesia. The use of psychologically informed practice may be beneficial in this patient population. There is ample research on various approaches to treating low back pain, however there is limited research investigating the efficacy of treatment for patients with low back pain and a previous history of opioid dependency. The purpose of this case report was to describe the physical therapy treatment, including pain management strategies, for a patient with low back pain, a previous history of opioid dependency (oxycodone), and apparent opiate induced hyperalgesia.https://dune.une.edu/pt_studcrposter/1103/thumbnail.jp

Induction of detoxification systems in wild red mullet Mullus surmuletus after microplastic ingestion

Marine litter greatly affects marine species and ecosystems (1), however there is little evidence of physiological responses of vertebrates to plastic exposure. In this study, wild mullets Mullus surmuletus were obtained from fishing vessels operating in Mallorca Island (W Mediterranean). Stomach content analyses and identification under microscope determined that 28% of the samples had ingested microplastics. Liver samples of surmullets with and without microplastic ingestion were analysed to determine physiological effects. Results suggest an induction of the detoxification system in M. surmuletus Linnaeus, 1758 but no oxidative stress or cellular damage

BREAKING THE PARADIGM: MARINE SEDIMENTS HOLD TWO-FOLD MICROPLASTICS THAN SEA SURFACE WATERS AND ARE DOMINATED BY FIBERS

Marine compartments are often considered independent environments in studies on plastic pollution (Ali et al., 2021). Consequently, little is known about microplastic (MPs) distribution amongst those habitats closely linked. Here, we perform an interactive assessment of MPs abundance and composition from the pelagic habitat to beaches integrating shallow seafloor sediments of a coastal Mediterranean marine protected area and evaluating MPs ingestion in holothurians, echinoderms, molluscs, and fishes inhabiting the area. We observed a gradient in the accumulation of MPs from the sea surface (0.17 ± 0.39 MPs/m2) to the seafloor (76 ± 108 MPs/m2) and beach sediment (13418 ± 28787 MPs/m2), with a skip of two orders of magnitude. Microplastic abundances fit with those reported for more anthropized Mediterranean areas and suggest coastal environments as potential debris sinking areas. Fibers dominate all the studied habitats. Holothurians showed the highest general MPs and fibers ingestion occurrence (91%), with greater values (9.48 ± 8.05 MPs/individual and 8.24 ± 7.95 fibers/individual) than those reported previously (Bulleri et al., 2021). Considering ecological key role, species distribution, and MPs ingestion values, we suggest Holothuroidea as suitable bioindicators for plastic pollution, particularly for fibers. Fibers are composed primarily of cellulose acetate (29%), whereas styrofoam of polystyrene (64%), and films, fragments, and filaments of a variable percentage of polyethylene and polypropylene. Differences found in the polymer composition amongst plastics´ morphologies are reflected in the variability observed between habitats and marine organisms. Particularly the polymer composition of fibers coincides with that of one of the MPs ingested by invertebrates. Results suggest that shape is a key plastic characteristic in determining polymer distribution patterns along with habitats and in marine species. Finally, this study highlights once again the importance and urgency of local and global actions needed to mitigate plastic pollution and particularly fiber release into the marine environment

Meningothelial Cells React to Elevated Pressure and Oxidative Stress

BACKGROUND: Meningothelial cells (MECs) are the cellular components of the meninges enveloping the brain. Although MECs are not fully understood, several functions of these cells have been described. The presence of desmosomes and tight junctions between MECs hints towards a barrier function protecting the brain. In addition, MECs perform endocytosis and, by the secretion of cytokines, are involved in immunological processes in the brain. However, little is known about the influence of pathological conditions on MEC function; e.g., during diseases associated with elevated intracranial pressure, hypoxia or increased oxidative stress. METHODS: We studied the effect of elevated pressure, hypoxia, and oxidative stress on immortalized human as well as primary porcine MECs. We used MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) bioreduction assays to assess the proliferation of MECs in response to treatment and compared to untreated control cells. To assess endocytotic activity, the uptake of fluorescently labeled latex beads was analyzed by fluorescence microscopy. RESULTS: We found that exposure of MECs to elevated pressure caused significant cellular proliferation and a dramatic decrease in endocytotic activity. In addition, mild oxidative stress severely inhibited endocytosis. CONCLUSION: Elevated pressure and oxidative stress impact MEC physiology and might therefore influence the microenvironment of the subarachnoid space and thus the cerebrospinal fluid within this compartment with potential negative impact on neuronal function

Global economic burden of unmet surgical need for appendicitis

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries