SANDBOX CONTRACTING: AN EVALUATION OF GAMIFIED VS. TRADITIONAL CONTRACTING TRAINING METHODS AT THE USAF ENLISTED CONTRACTING TECHNICAL SCHOOL

This thesis involved an evaluation of gamified versus current (traditional) training methods employed by the instructors and faculty at the Air Force’s 344th Training Squadron (344 TRS) at Lackland Air Force Base, Texas, and by the professors at the Naval Postgraduate School (NPS) in Monterey, California. For our project, we designed and developed a first-person shooter (FPS) video game, titled Sandbox Contracting, that teaches the player basic contracting skills. Over the course of six weeks, we utilized this FPS video game to conduct an experiment in which a control group received the current (traditional) training methods employed by 344 TRS and NPS and a treatment group received the gamified version of the training. We assessed each student’s learning as well as their reaction to the assigned learning modality (traditional versus gaming) using post-training evaluation surveys. Traditional training methods outperformed gamified methods in most cases, but not all. We found that game design and mechanics impacted the student’s reactions and ultimately, the success of using gamified methods for learning. Additionally, the results demonstrated a genuine interest in using games for learning among the Air Force contracting students, given the right game design and mechanics. Lastly, we offer suggestions for areas in which further research should be conducted in the gamified versus traditional training arena.Outstanding ThesisCaptain, United States Air ForceCaptain, United States Air ForceCaptain, United States Air ForceApproved for public release. Distribution is unlimited

Gamification in Defense Acquisition Training and Education

Excerpt from the Proceedings of the Nineteenth Annual Acquisition Research SymposiumLeveraging research conducted as part of an Acquisition Research Program sponsored thesis, this paper expands upon an essay written by our research team (submitted to USNI), in which we argue that gamified learning (building games to promote learning of traditional material) presents a unique opportunity for enhancing education and training within the defense workforce. We provide an in-depth explanation of what gamification is and why it might be particularly useful for enhancing learning in non-traditional defense contexts, using defense acquisition as a test case. We present initial evidence from our empirical research to highlight the opportunities and challenges for advancing military education into the present age through gamified learning methods. Finally, we outline future directions for research in gamification for defense applications, bringing attention to the need for collaboration across the defense-focused entities exploring the potential for gaming in future defense education and training.Approved for public release; distribution is unlimited

Molecular Evolution in Collapsing Prestellar Cores

We have investigated the evolution and distribution of molecules in collapsing prestellar cores via numerical chemical models, adopting the Larson-Penston solution and its delayed analogues to study collapse. Molecular abundances and distributions in a collapsing core are determined by the balance among the dynamical, chemical and adsorption time scales. When the central density n_H of a prestellar core with the Larson-Penston flow rises to 3 10^6 cm^{-3}, the CCS and CO column densities are calculated to show central holes of radius 7000 AU and 4000 AU, respectively, while the column density of N2H+ is centrally peaked. These predictions are consistent with observations of L1544. If the dynamical time scale of the core is larger than that of the Larson-Penston solution owing to magnetic fields, rotation, or turbulence, the column densities of CO and CCS are smaller, and their holes are larger than in the Larson-Penston core with the same central gas density. On the other hand, N2H+ and NH3 are more abundant in the more slowly collapsing core. Therefore, molecular distributions can probe the collapse time scale of prestellar cores. Deuterium fractionation has also been studied via numerical calculations. The deuterium fraction in molecules increases as a core evolves and molecular depletion onto grains proceeds. When the central density of the core is n_H=3 10^6 cm^{-3}, the ratio DCO+/HCO+ at the center is in the range 0.06-0.27, depending on the collapse time scale and adsorption energy; this range is in reasonable agreement with the observed value in L1544.Comment: 21 pages, 17 figure

Rotation of the pre-stellar core L1689B

The search for the onset of star formation in pre-stellar cores has focussed on the identification of an infall signature in the molecular line profiles of tracer species. The classic infall signature is a double peaked line profile with an asymmetry in the strength of the peaks such that the blue peak is stronger. L1689B is a pre-stellar core and infall candidate but new JCMT HCO+ line profile data, presented here, confirms that both blue and red asymmetric line profiles are present in this source. Moreover, a dividing line can be drawn between the locations where each type of profile is found. It is argued that it is unlikely that the line profiles can be interpreted with simple models of infall or outflow and that rotation of the inner regions is the most likely explanation. A rotational model is developed in detail with a new 3D molecular line transport code and it is found that the best type of model is one in which the rotational velocity profile is in between solid body and Keplerian. It is firstly shown that red and blue asymmetric line profiles can be generated with a rotation model entirely in the absence of any infall motion. The model is then quantitively compared with the JCMT data and an iteration over a range of parameters is performed to minmize the difference between the data and model. The results indicate that rotation can dominate the line profile shape even before the onset of infall.Comment: Accepted by MNRAS, 7 pages, 4 figure

An evaluation of a nurse led unit: an action research study

This study is an exemplar of working in a participatory way with members of the public and health and social care practitioners as co-researchers. A Nurse Consultant Older People working in a nurse-led bed, intermediate care facility in a community hospital acted as joint project lead with an academic researcher. From the outset, members of the public were part of a team of 16 individuals who agreed an evaluation focus and were involved in all stages of the research process from design through to dissemination. An extensive evaluation reflecting all these stakeholders’ preferences was undertaken. Methods included research and audit including: patient and carer satisfaction questionnaire surveys, individual interviews with patients, carers and staff, staff surveys, graffiti board, suggestion box, first impressions questionnaire, patient tracking and a bed census. A key aim of the study has been capacity building of the research team members which has also been evaluated. In terms of impact, the co-researchers have developed research skills and knowledge, grown in confidence, developed in ways that have impacted elsewhere in their lives, developed posters, presented at conferences and gained a better understanding of the NHS. The evaluation itself has provided useful information on the processes and outcomes of intermediate care on the ward which was used to further improve the service

The initial conditions of isolated star formation - VI. SCUBA mapping of prestellar cores

Observations have been carried out with SCUBA at the JCMT of 52 molecular cloud cores that do not contain any sign of protostellar activity. These are all therefore candidate prestellar cores, which are believed to represent the stage of star formation that precedes the formation of a protostar. 29 of the 52 cores were detected at 850 microns at varying levels of signal-to-noise ratio greater than 3 sigma at peak. The detected cores were split into 'bright' cores and `intermediate' cores, depending on their peak flux density at 850 microns. Cores with peak 850 microns flux densities greater than 170 mJy/beam were designated 'bright' (13 cores), while those flux densities below this value were designated 'intermediate' (16 cores). This dividing line corresponds to A_v~50 under typical assumptions. The data are combined with our previously published ISO data, and the physical parameters of the cores, such as density and temperature, are calculated. Detailed fitting of the bright core radial profiles shows that they are not critical Bonnor-Ebert spheres, in agreement with previous findings. However, we find that intermediate cores, such as B68 (which has previously been claimed to be a Bonnor-Ebert sphere), may in fact be consistent with the Bonnor-Ebert criterion, suggesting perhaps that cores pass through such a phase during their evolution. We make rough estimates of core lifetimes based on the statistics of detections and find that the lifetime of a prestellar core is roughly ~3x10^5 years, while that of a bright core is \~1.5x10^5 years. Comparisons with some magnetic and turbulence regulated collapse models show that no model can match all of the data. Models that are tuned to fit the total prestellar core lifetime, do not predict the relative numbers of cores seen at each stage.Comment: 23 pages, 52 figures, accepted by MNRAS, alternate PDF w/all figures available from http://www.astro.cf.ac.uk/pub/Derek.Ward-Thompson/publications.htm

The Milky Way Project: A statistical study of massive star formation associated with infrared bubbles

The Milky Way Project citizen science initiative recently increased the number of known infrared bubbles in the inner Galactic plane by an order of magnitude compared to previous studies. We present a detailed statistical analysis of this dataset with the Red MSX Source catalog of massive young stellar sources to investigate the association of these bubbles with massive star formation. We particularly address the question of massive triggered star formation near infrared bubbles. We find a strong positional correlation of massive young stellar objects (MYSOs) and H II regions with Milky Way Project bubbles at separations of < 2 bubble radii. As bubble sizes increase, a statistically significant overdensity of massive young sources emerges in the region of the bubble rims, possibly indicating the occurrence of triggered star formation. Based on numbers of bubble-associated RMS sources we find that 67+/-3% of MYSOs and (ultra)compact H II regions appear associated with a bubble. We estimate that approximately 22+/-2% of massive young stars may have formed as a result of feedback from expanding H II regions. Using MYSO-bubble correlations, we serendipitously recovered the location of the recently discovered massive cluster Mercer 81, suggesting the potential of such analyses for discovery of heavily extincted distant clusters.Comment: 16 pages, 17 figures. Accepted for publication in ApJ, comments welcome. Milky Way Project public data release available at http://www.milkywayproject.org/dat

The Hall effect in star formation

Magnetic fields play an important role in star formation by regulating the removal of angular momentum from collapsing molecular cloud cores. Hall diffusion is known to be important to the magnetic field behaviour at many of the intermediate densities and field strengths encountered during the gravitational collapse of molecular cloud cores into protostars, and yet its role in the star formation process is not well-studied. We present a semianalytic self-similar model of the collapse of rotating isothermal molecular cloud cores with both Hall and ambipolar diffusion, and similarity solutions that demonstrate the profound influence of the Hall effect on the dynamics of collapse. The solutions show that the size and sign of the Hall parameter can change the size of the protostellar disc by up to an order of magnitude and the protostellar accretion rate by fifty per cent when the ratio of the Hall to ambipolar diffusivities is varied between -0.5 <= eta_H / eta_A <= 0.2. These changes depend upon the orientation of the magnetic field with respect to the axis of rotation and create a preferred handedness to the solutions that could be observed in protostellar cores using next-generation instruments such as ALMA. Hall diffusion also determines the strength and position of the shocks that bound the pseudo and rotationally-supported discs, and can introduce subshocks that further slow accretion onto the protostar. In cores that are not initially rotating Hall diffusion can even induce rotation, which could give rise to disc formation and resolve the magnetic braking catastrophe. The Hall effect clearly influences the dynamics of gravitational collapse and its role in controlling the magnetic braking and radial diffusion of the field merits further exploration in numerical simulations of star formation.Comment: 22 pages, 10 figures, accepted by MNRA

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Aims/hypothesis Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also feeds mitochondrial anaplerotic pathways, driving citrate export and cytosolic malonyl-CoA production by the acetyl-CoA carboxylase 1 (ACC1) enzyme. This pathway has been proposed as an alternative glucose-sensing mechanism, supported mainly by in vitro data. Here, we sought to address the role of the beta cell ACC1-coupled pathway in insulin secretion and glucose homeostasis in vivo. Methods Acaca, encoding ACC1 (the principal ACC isoform in islets), was deleted in beta cells of mice using the Cre/loxP system. Acaca floxed mice were crossed with Ins2cre mice (βACC1KO; life-long beta cell gene deletion) or Pdx1creER mice (tmx-βACC1KO; inducible gene deletion in adult beta cells). Beta cell function was assessed using in vivo metabolic physiology and ex vivo islet experiments. Beta cell mass was analysed using histological techniques. Results βACC1KO and tmx-βACC1KO mice were glucose intolerant and had defective insulin secretion in vivo. Isolated islet studies identified impaired insulin secretion from beta cells, independent of changes in the abundance of neutral lipids previously implicated as amplification signals. Pancreatic morphometry unexpectedly revealed reduced beta cell size in βACC1KO mice but not in tmx-βACC1KO mice, with decreased levels of proteins involved in the mechanistic target of rapamycin kinase (mTOR)-dependent protein translation pathway underpinning this effect. Conclusions/interpretation Our study demonstrates that the beta cell ACC1-coupled pathway is critical for insulin secretion in vivo and ex vivo and that it is indispensable for glucose homeostasis. We further reveal a role for ACC1 in controlling beta cell growth prior to adulthood

CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth

Engineering T cells to express chimeric antigen receptors (CARs) specific for antigens on hematological cancers has yielded remarkable clinical responses, but with solid tumors, benefit has been more limited. This may reflect lack of suitable target antigens, immune evasion mechanisms in malignant cells, and/or lack of T cell infiltration into tumors. An alternative approach, to circumvent these problems, is targeting the tumor vasculature rather than the malignant cells directly. CLEC14A is a glycoprotein selectively overexpressed on the vasculature of many solid human cancers and is, therefore, of considerable interest as a target antigen. Here, we generated CARs from 2 CLEC14A-specific antibodies and expressed them in T cells. In vitro studies demonstrated that, when exposed to their target antigen, these engineered T cells proliferate, release IFN-γ, and mediate cytotoxicity. Infusing CAR engineered T cells into healthy mice showed no signs of toxicity, yet these T cells targeted tumor tissue and significantly inhibited tumor growth in 3 mouse models of cancer (Rip-Tag2, mPDAC, and Lewis lung carcinoma). Reduced tumor burden also correlated with significant loss of CLEC14A expression and reduced vascular density within malignant tissues. These data suggest the tumor vasculature can be safely and effectively targeted with CLEC14A-specific CAR T cells, offering a potent and widely applicable therapy for cancer