Validity, reliability, acceptability, and utility of the Social Inclusion Questionnaire User Experience (SInQUE): a clinical tool to facilitate social inclusion amongst people with severe mental health problems.

BACKGROUND: Individuals with severe mental health problems are at risk of social exclusion, which may complicate their recovery. Mental health and social care staff have, until now, had no valid or reliable way of assessing their clients' social inclusion. The Social Inclusion Questionnaire User Experience (SInQUE) was developed to address this. It assesses five domains: social integration; productivity; consumption; access to services; and political engagement, in the year prior to first psychiatric admission (T1) and the year prior to interview (T2) from which a total score at each time point can be calculated. AIMS: To establish the validity, reliability, and acceptability of the SInQUE in individuals with a broad range of psychiatric diagnoses receiving care from community mental health services and its utility for mental health staff. METHOD: Participants were 192 mental health service users with psychosis, personality disorder, or common mental disorder (e.g., depression, anxiety) who completed the SInQUE alongside other validated outcome measures. Test-retest reliability was assessed in a sub-sample of 30 participants and inter-rater reliability was assessed in 11 participants. SInQUE ratings of 28 participants were compared with those of a sibling with no experience of mental illness to account for shared socio-cultural factors. Acceptability and utility of the tool were assessed using completion rates and focus groups with staff. RESULTS: The SInQUE demonstrated acceptable convergent validity. The total score and the Social Integration domain score were strongly correlated with quality of life, both in the full sample and in the three diagnostic groups. Discriminant validity and test-retest reliability were established across all domains, although the test-retest reliability on scores for the Service Access and Political Engagement domains prior to first admission to hospital (T1) was lower than other domains. Inter-rater reliability was excellent for all domains at T1 and T2. CONCLUSIONS: The component of the SInQUE that assesses current social inclusion has good psychometric properties and can be recommended for use by mental health staff

The development of the forms of responding to self-critical thoughts Scale (FoReST)

Background: Self-critical thoughts are a feature of many mental health problems. Adopting a psychologically flexible response to thoughts has been highlighted as a key determinant of wellbeing. But, the measurement of psychological flexibility (PF) in relation to self-critical thoughts is under-developed. This paper reports on the development of the Forms of Responding to Self-Critical Thoughts Scale (FoReST). Method: Study One involved the development and exploratory factor analysis of the FoReST in a convenience sample of 253 non-clinical adults. Study Two was a confirmatory factor analysis study of the FoReST in a sample of 110 University students. Study 3 explored the convergent and concurrent validity of the FoReST by examining associations with measures of similar constructs (PF, self-compassion, self-criticism) and relevant mental health measures (anxiety, depression, distress). Study 3 also explored the FoReST’s incremental validity for predicting depression and anxiety levels beyond an established measure of self-critical thinking. Results: In Study One, exploratory factor analysis produced a 9-item/2-factor solution (unworkable action and mindful acceptance). The measure demonstrated good internal consistency. In Study 2, the confirmatory factor analysis also indicated a 2-factor model (unworkable action and mindful acceptance) and overall internal consistency that was excellent. In Study Three, the FoReST demonstrated high convergent validity with similar measures, and good concurrent validity with mental health outcomes. Analyses also indicated good incremental validity for the FoReST for predicting HADS depression and anxiety scores. Conclusions: The FoReST appears to be a psychometrically sound measure suitable for measuring change processes in third wave therapies such as Acceptance and Commitment Therapy, Mindfulness-based Interventions and Compassion Focused therapy

On the Lack of a Soft X-Ray Excess from Clusters of Galaxies

A soft X-ray excess has been claimed to exist in and around a number of galaxy clusters and this emission has been attributed to the warm-hot intergalactic medium that may constitute most of the baryons in the local universe. We have re-examined a study of the XMM-Newton observations on this topic by Kaastra et al. (2003) and find that the X-ray excess (or deficit) depends upon Galactic latitude and appears to be most closely related to the surface brightness of the 1/4 keV emission, which is largely due to emission from the Local hot bubble and the halo of the Milky Way. We suggest that the presence of the soft X-ray excess is due to incorrect subtraction of the soft X-ray background. An analysis is performed where we choose a 1/4 keV background that is similar to the background near the cluster (and for similar HI column). We find that the soft X-ray excess largely disappears using our background subtraction and conclude that these soft X-ray excesses are not associated with the target clusters. We also show that the detections of "redshifted" O VII lines claimed by Kaastra et al. (2003) are correlated with solar system charge exchange emission suggesting that they are not extragalactic either.Comment: 8 pages, 6 figures, accepted for publication in Ap

Function of caspase-14 in trophoblast differentiation

<p>Abstract</p> <p>Background</p> <p>Within the human placenta, the cytotrophoblast consists of a proliferative pool of progenitor cells which differentiate to replenish the overlying continuous, multi-nucleated syncytiotrophoblast, which forms the barrier between the maternal and fetal tissues. Disruption to trophoblast differentiation and function may result in impaired fetal development and preeclampsia. Caspase-14 expression is limited to barrier forming tissues. It promotes keratinocyte differentiation by cleaving profilaggrin to stabilise keratin intermediate filaments, and indirectly providing hydration and UV protection. However its role in the trophoblast remains unexplored.</p> <p>Methods</p> <p>Using RNA Interference the reaction of control and differentiating trophoblastic BeWo cells to suppressed caspase-14 was examined for genes pertaining to hormonal, cell cycle and cytoskeletal pathways.</p> <p>Results</p> <p>Transcription of hCG, KLF4 and cytokeratin-18 were increased following caspase-14 suppression suggesting a role for caspase-14 in inhibiting their pathways. Furthermore, hCG, KLF4 and cytokeratin-18 protein levels were disrupted.</p> <p>Conclusion</p> <p>Since expression of these molecules is normally increased with trophoblast differentiation, our results imply that caspase-14 inhibits trophoblast differentiation. This is the first functional study of this unusual member of the caspase family in the trophoblast, where it has a different function than in the epidermis. This knowledge of the molecular underpinnings of trophoblast differentiation may instruct future therapies of trophoblast disease.</p

Cosmic Microwave Background Anisotropy Window Functions Revisited

The primary results of most observations of cosmic microwave background (CMB) anisotropy are estimates of the angular power spectrum averaged through some broad band, called band-powers. These estimates are in turn what are used to produce constraints on cosmological parameters due to all CMB observations. Essential to this estimation of cosmological parameters is the calculation of the expected band-power for a given experiment, given a theoretical power spectrum. Here we derive the "band power" window function which should be used for this calculation, and point out that it is not equivalent to the window function used to calculate the variance. This important distinction has been absent from much of the literature: the variance window function is often used as the band-power window function. We discuss the validity of this assumed equivalence, the role of window functions for experiments that constrain the power in {\it multiple} bands, and summarize a prescription for reporting experimental results. The analysis methods detailed here are applied in a companion paper to three years of data from the Medium Scale Anisotropy Measurement.Comment: 5 pages, 1 included .eps figure, PRD in press---final published versio

Speech rhythm: a metaphor?

Is speech rhythmic? In the absence of evidence for a traditional view that languages strive to coordinate either syllables or stress-feet with regular time intervals, we consider the alternative that languages exhibit contrastive rhythm subsisting merely in the alternation of stronger and weaker elements. This is initially plausible, particularly for languages with a steep ‘prominence gradient’, i.e. a large disparity between stronger and weaker elements; but we point out that alternation is poorly achieved even by a ‘stress-timed’ language such as English, and, historically, languages have conspicuously failed to adopt simple phonological remedies that would ensure alternation. Languages seem more concerned to allow ‘syntagmatic contrast’ between successive units and to use durational effects to support linguistic functions than to facilitate rhythm. Furthermore, some languages (e.g. Tamil, Korean) lack the lexical prominence which would most straightforwardly underpin prominence alternation. We conclude that speech is not incontestibly rhythmic, and may even be antirhythmic. However, its linguistic structure and patterning allow the metaphorical extension of rhythm in varying degrees and in different ways depending on the language, and that it is this analogical process which allows speech to be matched to external rhythms

Hardness as a Spectral Peak Estimator for Gamma-Ray Bursts

Simple hardness ratios are found to be a good estimator for the spectral peak energy in Gamma-Ray Bursts (GRBs). Specifically, a high correlation strength is found between the $\nu F_{\nu}$ peak in the spectrum of BATSE GRBs, \epo, and the hardness of GRBs, \hr, as defined by the fluences in channels 3 and 4, divided by the combined fluences in channels 1 and 2 of the BATSE Large Area Detectors. The correlation is independent of the type of the burst, whether Long-duration GRB (LGRB) or Short-duration (SGRB) and remains almost linear over the wide range of the BATSE energy window (20-2000 KeV). Based on Bayes theorem and Markov Chain Monte Carlo techniques, we also present multivariate analyses of the observational data while accounting for data truncation and sample-incompleteness. Prediction intervals for the proposed \hrep ~relation are derived. Results and further simulations are used to compute \epo estimates for nearly the entire BATSE catalog: 2130 GRBs. These results may be useful for investigating the cosmological utility of the spectral peak in GRBs intrinsic luminosity estimates.Comment: MNRAS submitted, Some technical side analyses removed or reduced following the referee's review, 68 pages, 13 figure

Stellar Companions to Stars with Planets

A combination of high-resolution and wide-field imaging reveals two binary stars and one triple star system among the sample of the first 11 stars with planets detected by radial velocity variations. High resolution speckle or adaptive optics (AO) data probe subarcsecond scales down to the diffraction limit of the Keck 10-m or Lick 3-m, and direct images or AO images are sensitive to a wider field, extending to 10" or 38", depending upon the camera. One of the binary systems -- HD 114762 -- was not previously known to be a spatially resolved multiple system; additional data taken with the combination of Keck adaptive optics and NIRSPEC are used to characterize the new companion. The second binary system -- Tau Boo -- was a known multiple with two conflicting orbital solutions; the current data will help constrain the discrepant estimates of periastron time and separation. Another target -- 16 Cyg B -- was a known common proper motion binary, but the current data resolve a new third component, close to the wide companion 16 Cyg A. Both the HD 114762 and 16 Cyg B systems harbor planets in eccentric orbits, while the Tau Boo binary contains an extremely close planet in a tidally-circularized orbit. Although the sample is currently small, the proportion of binary systems is comparable to that measured in the field over a similar separation range. Incorporating the null result from another companion search project lowers the overall fraction of planets in binary systems, but the detections in our survey reveal that planets can form in binaries separated by less than 50 AU.Comment: 5 Tables, 16 Figures. ApJ, accepte

Radio emission models of Colliding-Wind Binary Systems

We present calculations of the spatial and spectral distribution of the radio emission from a wide WR+OB colliding-wind binary system based on high-resolution hydrodynamical simulations and solutions to the radiative transfer equation. We account for both thermal and synchrotron radio emission, free-free absorption in both the unshocked stellar wind envelopes and the shocked gas, synchrotron self-absorption, and the Razin effect. The applicability of these calculations to modelling radio images and spectra of colliding-wind systems is demonstrated with models of the radio emission from the wide WR+OB binary WR147. Its synchrotron spectrum follows a power-law between 5 and 15 GHz but turns down to below this at lower and higher frequencies. We find that while free-free opacity from the circum-binary stellar winds can potentially account for the low-frequency turnover, models that also include a combination of synchrotron self-absorption and Razin effect are favoured. We argue that the high-frequency turn down is a consequence of inverse-Compton cooling. We present our resulting spectra and intensity distributions, along with simulated MERLIN observations of these intensity distributions. From these we argue that the inclination of the WR147 system to the plane of the sky is low. We summarise by considering extensions of the current model that are important for models of the emission from closer colliding wind binaries, in particular the dramatically varying radio emission of WR140.Comment: 18 pages, 18 figures; Accepted by Astronomy and Astrophysics, July 8, 200

XMM−NewtonXMM-Newton Ω\Omega project: III. Gas mass fraction shape in high redshift clusters

We study the gas mass fraction, $f\_{\rm gas},$ behavior in $XMM-Newton$ $\Omega$ project. The typical $f\_{\rm gas}$ shape of high redshift galaxy clusters follows the global shape inferred at low redshift quite well. This result is consistent with the gravitational instability picture leading to self similar structures for both the dark and baryonic matter. However, the mean $f\_{\rm gas} in distant clusters shows some differences to local ones, indicating a departure from strict scaling. This result is consistent with the observed evolution in the luminosity-temperature relation. We quantitatively investigate this departure from scaling laws. Within the local sample we used, a moderate but clear variation of the amplitude of the gas mass fraction with temperature is found, a trend that weakens in the outer regions. These variations do not explain departure from scaling laws of our distant clusters. An important implication of our results is that the gas fraction evolution, a test of the cosmological parameters, can lead to biased values when applied at radii smaller than the virial radius. From our$XMM$ clusters, the apparent gas fraction at the virial radius is consistent with a non-evolving universal value in a high matter density model and not with a concordance.Comment: Accepted, A&A, in pres