OCCUPATIONAL HAZARDS TO PEST CONTROL OPERATORS WITH SPECIAL REFERENCE TO PESTICIDES

With the help of one of your expert operators I have selected eight pesticides which I understand are widely used in vertebrate pest control, and with one exception, pose substantial safety problems for operators. These pesticides are the anticoagulants, zinc phosphide, 1080, strychnine, thallium sulfate, anhydrous ammonia, carbon disulfide, and methyl bromide. Except for the anticoagulants, it would be hard to assemble a more lethal group of chemicals. I wonder if the talents of chemical research should not be brought into this picture more actively, so that less hazardous materials could be developed for vertebrate pest control. Perhaps the economic incentives do not stimulate in this direction. Nevertheless the vertebrate pest control operators have a reasonably good record as far as acute occupational poisoning is concerned. Either you are careful, lucky, or whatever health problems which may be occurring are not being recognized. One fortunate circumstance is that a good portion of the chemicals you use are not easily absorbed through the intact skin, a property which reduces the hazard to operators considerably. On the attached table is presented a summary of the properties and hazards of the eight chemicals together with information about the protection of the operator using them. Also attached is a list of safety rules for workers handling pesticides (to be discussed in the oral presentation.) Also I\u27d like to present some actual cases of poisoning or other harmful effects experienced by California workers to illustrate how operators may experience difficulties. Although none of these cases occurred to operators dealing with vertebrate pests they do concern the pesticides on our list

“They say one thing and mean another”: How differences in in-group understandings of key goals shape political knowledge : An international comparison of politicians and journalists

Peer reviewe

W3W_3 string scattering

The group theoretic method is extended to include fields with a background charge. This formalism is used to compute the tree level scattering for $W_3$ strings. The scattering amplitudes involve Ising model correlation functions. A detailed study of the four tachyon amplitude shows that the $W_3$ string must possess additional states in its spectrum associated with intercept $1/2$ and the energy operator of the Ising model.Comment: 11 pages, KCL-TH-92-4/NI 9200

Microtubule depolymerization by the kinesin-8 motor Kip3p: a mathematical model

Proteins from the kinesin-8 family promote microtubule (MT) depolymerization, a process thought to be important for the control of microtubule length in living cells. In addition to this MT shortening activity, kinesin 8s are motors that show plus-end directed motility on MTs. Here we describe a simple model that incorporates directional motion and destabilization of the MT plus end by kinesin 8. Our model quantitatively reproduces the key features of length-vs-time traces for stabilized MTs in the presence of purified kinesin 8, including length-dependent depolymerization. Comparison of model predictions with experiments suggests that kinesin 8 depolymerizes processively, i.e., one motor can remove multiple tubulin dimers from a stabilized MT. Fluctuations in MT length as a function of time are related to depolymerization processivity. We have also determined the parameter regime in which the rate of MT depolymerization is length dependent: length-dependent depolymerization occurs only when MTs are sufficiently short; this crossover is sensitive to the bulk motor concentration.Comment: 34 pages, 11 figure

On the quantum KP hierarchy and its relation to the non-linear Schr\"odinger equation

We establish a relation between the classical non-linear Schr\"odinger equation and the KP hierarchy, and we extend this relation to the quantum case by defining a quantum KP hierarchy. We present evidence that an integrable hierarchy of equations is obtained by quantizing the first Hamiltonian structure of the KdV equation. The connection between infinite-dimensional algebras and integrable models is discussed.Comment: 16 pages, KCL-TH-92-

Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life

BACKGROUND: In 1995 a meta-analysis of randomised trials investigating the value of adding chemotherapy to primary treatment for non-small cell lung cancer (NSCLC) suggested a small survival benefit for cisplatin-based chemotherapy in each of the primary treatment settings. However, the metaanalysis included many small trials and trials with differing eligibility criteria and chemotherapy regimens. METHODS: The aim of the Big Lung Trial was to confirm the survival benefits seen in the meta-analysis and to assess quality of life and cost in the supportive care setting. A total of 725 patients were randomised to receive supportive care alone (n = 361) or supportive care plus cisplatin-based chemotherapy (n = 364). RESULTS: 65% of patients allocated chemotherapy (C) received all three cycles of treatment and a further 27% received one or two cycles. 74% of patients allocated no chemotherapy (NoC) received thoracic radiotherapy compared with 47% of the C group. Patients allocated C had a significantly better survival than those allocated NoC: HR 0.77 (95% CI 0.66 to 0.89, p = 0.0006), median survival 8.0 months for the C group v 5.7 months for the NoC group, a difference of 9 weeks. There were 19 (5%) treatment related deaths in the C group. There was no evidence that any subgroup benefited more or less fromchemotherapy. No significant differences were observed between the two groups in terms of the pre-defined primary and secondary quality of life end points, although large negative effects of chemotherapy were ruled out. The regimens used proved to be cost effective, the extra cost of chemotherapy being offset by longer survival. CONCLUSIONS: The survival benefit seen in this trial was entirely consistent with the NSCLC meta-analysis and subsequent similarly designed large trials. The information on quality of life and cost should enablepatients and their clinicians to make more informed treatment choices

Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery

Objective Due to the global increase in obesity rates and success of bariatric surgery in weight reduction, an increasing number of women now present pregnant with a previous bariatric procedure. This study investigates the extent of bariatric-associated metabolic and gut microbial alterations during pregnancy and their impact on fetal development. Design A parallel metabonomic (molecular phenotyping based on proton nuclear magnetic resonance spectroscopy) and gut bacterial (16S ribosomal RNA gene amplicon sequencing) profiling approach was used to determine maternal longitudinal phenotypes associated with malabsorptive/mixed (n=25) or restrictive (n=16) procedures, compared with women with similar early pregnancy body mass index but without bariatric surgery (n=70). Metabolic profiles of offspring at birth were also analysed. Results Previous malabsorptive, but not restrictive, procedures induced significant changes in maternal metabolic pathways involving branched-chain and aromatic amino acids with decreased circulation of leucine, isoleucine and isobutyrate, increased excretion of microbial-associated metabolites of protein putrefaction (phenylacetlyglutamine, p-cresol sulfate, indoxyl sulfate and p-hydroxyphenylacetate), and a shift in the gut microbiota. The urinary concentration of phenylacetylglutamine was significantly elevated in malabsorptive patients relative to controls (p=0.001) and was also elevated in urine of neonates born from these mothers (p=0.021). Furthermore, the maternal metabolic changes induced by malabsorptive surgery were associated with reduced maternal insulin resistance and fetal/birth weight. Conclusion Metabolism is altered in pregnant women with a previous malabsorptive bariatric surgery. These alterations may be beneficial for maternal outcomes, but the effect of elevated levels of phenolic and indolic compounds on fetal and infant health should be investigated further

Vertical Confinement and Evolution of Reentrant Insulating Transition in the Fractional Quantum Hall Regime

We have observed an anomalous shift of the high field reentrant insulating phases in a two-dimensional electron system (2DES) tightly confined within a narrow GaAs/AlGaAs quantum well. Instead of the well-known transitions into the high field insulating states centered around $\nu = 1/5$, the 2DES confined within an 80\AA-wide quantum well exhibits the transition at $\nu = 1/3$. Comparably large quantum lifetime of the 2DES in narrow well discounts the effect of disorder and points to confinement as the primary driving force behind the evolution of the reentrant transition.Comment: 5 pages, 4 figure

Snow petrel stomach-oil deposits as a new biological archive of Antarctic sea ice

Where snow petrels forage is predominantly a function of sea ice. They spit stomach oil in defence, and accumulated deposits at nesting sites are providing new opportunities to reconstruct their diet, and, in turn, the sea-ice environment over past millennia