A theory of coworking: entrepreneurial communities, immaterial commons and working futures

This thesis explores contemporary experiences of entrepreneurial knowledge work in emerging and rapidly changing areas of economy and society through a detailed ethnographic analysis of the motivations, social practices and changing experiences of a pioneering Coworking community in Melbourne, Australia. Coworking is a complex social phenomenon. Whilst ‘Coworking spaces’ are open plan office environments that mobile, independent knowledge workers share as places of work, ‘Coworking practices’ are the methods by which these independent actors choose to work in close proximity, interact socially and sometimes collaborate on shared projects. Since its emergence in 2005, the rapid global expansion of Coworking has been regarded as both an expression of, and response to, significant changes in how knowledge work is performed and organised. As the processes of globalisation and technological innovation continue to transform working practices and cultures, ‘Coworkers’ have been held up as early adopters of disruptive trends in mobile and distributed knowledge work, and ‘Coworking spaces’ have been regarded as emblematic sites within evolving entrepreneurial knowledge economies. These claims present Coworking spaces as compelling sites in which to conduct social inquiry. Curiously, ‘community’ has been advanced as the central organising construct around which Coworking has rapidly expanded, and yet many scholarly analyses have problematised this construct in examining specific Coworking arrangements. This thesis takes up this theme by offering a comprehensive theoretical treatment of the ‘concept of community’ within Coworking and wider entrepreneurial cultures, and a careful empirical examination of the ‘community constructing practices’ that may be said to characterise these cultures. This investigation is grounded in a rigorous ethnographic analysis of the social practices of a pioneering Coworking community in Melbourne, conducted between 2012 and 2017. The ethnography is guided by three key questions, ‘why people Cowork’, ‘how they Cowork’ and ‘how Coworking experiences change over time’. Although the literature investigating Coworking has grown during the period of this research, a thorough examination of the core social practices that constitute Coworking, and especially the tensions evoked as Coworking experiences change over time, has not been accomplished until now. Methodologically, this thesis comprises a ‘grounded theory ethnography’ dedicated to empirically describing and analysing the core social practices that constituted Coworking for this pioneering Melbourne community. The analysis is informed by theories of ‘communities of practice’, ‘immaterial labour’ and ‘the commons’, which I use to conceptualise the collective product of Coworking labour as a shared ‘immaterial commons’ that is subject to a distinct set of social dilemmas germane to ‘commonsbased peer production’. Hence, the central finding of this thesis is that entrepreneurial communities produce immaterial commons that require appropriate governance arrangements to be sustained and renewed. This finding makes two contributions to the scholarly literature. Empirically, the thesis contributes to the emerging literature on Coworking by providing a detailed examination of social practices observed within a Coworking community as it evolved over time. Theoretically, it proposes a novel conception of the collective product of immaterial labour as a commonly pooled resource, and in doing so proposes a pathway for research that examines the organisation and governance dilemmas that are likely to emerge in the future within specific ‘entrepreneurial communities’ and the knowledge work they produce

The composition of circumstellar gas and dust in 51 Oph

We analyze ISO archive data of the nearby bright emission-line star 51 Oph, previously classified as a proto-planetary system similar to beta Pic. The infrared spectrum reveals the presence of gas-phase emission bands of hot (approx 850 K) CO, CO_2, H_2O and NO. In addition to this, partially crystalline silicate dust is present. The solid-state bands and the energy distribution are indicative of dust that has formed recently, rather than of debris dust. The presence of hot molecular gas and the composition of the circumstellar dust are highly unusual for a young star and are reminiscent of what is found around evolved (AGB) stars, although we exclude the possibility of 51 Oph belonging to this group. We suggest several explanations for the nature of 51 Oph, including a recent episode of mass loss from a Be star, and the recent destruction of a planet-sized body around a young star.Comment: 4 pages, 3 figures, accepted by A&A (letters

Lack of trust in maternal support is associated with negative interpretations of ambiguous maternal behavior

Attachment theory assumes that children who lack trust in maternal availability for support are more inclined to interpret maternal behavior in congruence with their expectation that mother will remain unavailable for support. To provide the first test of this assumption, early adolescents (9-13 years old) were asked to assess whether ambiguous interactions with mother should be interpreted in a positive or a negative way. In our sample (n = 322), results showed that early adolescents' lack of trust in their mother's availability for support was related to more negative interpretations of maternal behavior. The associations remained significant after controlling for depressive mood. The importance of these findings for our understanding of attachment theory, attachment stability, and clinical practice are discussed

Optically trapped bacteria pairs reveal discrete motile response to control aggregation upon cell–cell approach

Aggregation of bacteria plays a key role in the formation of many biofilms. The critical first step is cell–cell approach, and yet the ability of bacteria to control the likelihood of aggregation during this primary phase is unknown. Here, we use optical tweezers to measure the force between isolated Bacillus subtilis cells during approach. As we move the bacteria towards each other, cell motility (bacterial swimming) initiates the generation of repulsive forces at bacterial separations of ~3 μm. Moreover, the motile response displays spatial sensitivity with greater cell–cell repulsion evident as inter-bacterial distances decrease. To examine the environmental influence on the inter-bacterial forces, we perform the experiment with bacteria suspended in Tryptic Soy Broth, NaCl solution and deionised water. Our experiments demonstrate that repulsive forces are strongest in systems that inhibit biofilm formation (Tryptic Soy Broth), while attractive forces are weak and rare, even in systems where biofilms develop (NaCl solution). These results reveal that bacteria are able to control the likelihood of aggregation during the approach phase through a discretely modulated motile response. Clearly, the force-generating motility we observe during approach promotes biofilm prevention, rather than biofilm formation

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity for new strategies to treat type 2 diabetes and insulin resistance, with recent genetic and pharmacological studies indicating the α2β2γ1 isoform combination as the heterotrimer complex primarily responsible. With the goal of developing α2β2-specific activators, here we perform structure/function analysis of the 2-hydroxybiphenyl group of SC4, an activator with tendency for α2-selectivity that is also capable of potently activating β2 complexes. Substitution of the LHS 2-hydroxyphenyl group with polar-substituted cyclohexene-based probes resulted in two AMPK agonists, MSG010 and MSG011, which did not display α2-selectivity when screened against a panel of AMPK complexes. By radiolabel kinase assay, MSG010 and MSG011 activated α2β2γ1 AMPK with one order of magnitude greater potency than the pan AMPK activator MK-8722. A crystal structure of MSG011 complexed to AMPK α2β1γ1 revealed a similar binding mode to SC4 and the potential importance of an interaction between the SC4 2-hydroxyl group and α2-Lys31 for directing α2-selectivity. MSG011 induced robust AMPK signalling in mouse primary hepatocytes and commonly used cell lines, and in most cases this occurred in the absence of changes in phosphorylation of the kinase activation loop residue α-Thr172, a classical marker of AMP-induced AMPK activity. These findings will guide future design of α2β2-selective AMPK activators, that we hypothesise may avoid off-target complications associated with indiscriminate activation of AMPK throughout the body

Mid-Infrared Imaging of Candidate Vega-Like Systems

We have conducted deep mid-infrared imaging of a relatively nearby sample of candidate Vega-like stars using the OSCIR instrument on the CTIO 4-meter and Keck II 10-meter telescopes. Our discovery of a spatially-resolved disk around HR 4796A has already been reported (Jayawardhana et al. 1998). Here we present imaging observations of the other members of the sample, including the discovery that only the primary in the HD 35187 binary system appears to harbor a substantial circumstellar disk and the possible detection of extended disk emission around 49 Ceti. We derive global properties of the dust disks, place constraints on their sizes, and discuss several interesting cases in detail. Although our targets are believed to be main sequence stars, we note that several have large infrared excesses compared to prototype Vega-like systems, and may therefore be somewhat younger. The disk size constraints we derive, in many cases, imply emission from relatively large ($\gtrsim$ 10$\mu$m) particles at mid-infrared wavelengths.Comment: 15 pages and 2 PostScript figures, accepted for publication in The Astronomical Journa

Does publication bias inflate the apparent efficacy of psychological treatment for major depressive disorder? A systematic review and meta-analysis of US national institutes of health-funded trials

Background The efficacy of antidepressant medication has been shown empirically to be overestimated due to publication bias, but this has only been inferred statistically with regard to psychological treatment for depression. We assessed directly the extent of study publication bias in trials examining the efficacy of psychological treatment for depression. Methods and Findings We identified US National Institutes of Health grants awarded to fund randomized clinical trials comparing psychological treatment to control conditions or other treatments in patients diagnosed with major depressive disorder for the period 1972–2008, and we determined whether those grants led to publications. For studies that were not published, data were requested from investigators and included in the meta-analyses. Thirteen (23.6%) of the 55 funded grants that began trials did not result in publications, and two others never started. Among comparisons to control conditions, adding unpublished studies (Hedges’ g = 0.20; CI95% -0.11~0.51; k = 6) to published studies (g = 0.52; 0.37~0.68; k = 20) reduced the psychotherapy effect size point estimate (g = 0.39; 0.08~0.70) by 25%. Moreover, these findings may overestimate the "true" effect of psychological treatment for depression as outcome reporting bias could not be examined quantitatively. Conclusion The efficacy of psychological interventions for depression has been overestimated in the published literature, just as it has been for pharmacotherapy. Both are efficacious but not to the extent that the published literature would suggest. Funding agencies and journals should archive both original protocols and raw data from treatment trials to allow the detection and correction of outcome reporting bias. Clinicians, guidelines developers, and decision makers should be aware that the published literature overestimates the effects of the predominant treatments for depression

Study of CP violation in Dalitz-plot analyses of B0 --> K+K-KS, B+ --> K+K-K+, and B+ --> KSKSK+

We perform amplitude analyses of the decays $B^0 \to K^+K^-K^0_S$, $B^+ \rightarrow K^+K^-K^+$, and $B^+ \to K^0_S K^0_S K^+$, and measure CP-violating parameters and partial branching fractions. The results are based on a data sample of approximately $470\times 10^6$ $B\bar{B}$ decays, collected with the BABAR detector at the PEP-II asymmetric-energy $B$ factory at the SLAC National Accelerator Laboratory. For $B^+ \to K^+K^-K^+$, we find a direct CP asymmetry in $B^+ \to \phi(1020)K^+$ of $A_{CP}= (12.8\pm 4.4 \pm 1.3)$, which differs from zero by $2.8 \sigma$. For $B^0 \to K^+K^-K^0_S$, we measure the CP-violating phase $\beta_{\rm eff} (\phi(1020)K^0_S) = (21\pm 6 \pm 2)^\circ$. For $B^+ \to K^0_S K^0_S K^+$, we measure an overall direct CP asymmetry of $A_{CP} = (4 ^{+4}_{-5} \pm 2)$. We also perform an angular-moment analysis of the three channels, and determine that the $f_X(1500)$ state can be described well by the sum of the resonances $f_0(1500)$, $f_2^{\prime}(1525)$, and $f_0(1710)$.Comment: 35 pages, 68 postscript figures. v3 - minor modifications to agree with published versio

Evidence for the h_b(1P) meson in the decay Upsilon(3S) --> pi0 h_b(1P)

Using a sample of 122 million Upsilon(3S) events recorded with the BaBar detector at the PEP-II asymmetric-energy e+e- collider at SLAC, we search for the $h_b(1P)$ spin-singlet partner of the P-wave chi_{bJ}(1P) states in the sequential decay Upsilon(3S) --> pi0 h_b(1P), h_b(1P) --> gamma eta_b(1S). We observe an excess of events above background in the distribution of the recoil mass against the pi0 at mass 9902 +/- 4(stat.) +/- 2(syst.) MeV/c^2. The width of the observed signal is consistent with experimental resolution, and its significance is 3.1sigma, including systematic uncertainties. We obtain the value (4.3 +/- 1.1(stat.) +/- 0.9(syst.)) x 10^{-4} for the product branching fraction BF(Upsilon(3S)-->pi0 h_b) x BF(h_b-->gamma eta_b).Comment: 8 pages, 4 postscript figures, submitted to Phys. Rev. D (Rapid Communications

Recommendations for defining preventable HIV-related mortality for public health monitoring in the era of Getting to Zero: an expert consensus

Getting to Zero is a commonly cited strategic aim to reduce mortality due to both HIV and avoidable deaths among people with HIV. However, no clear definitions are attached to these aims with regard to what constitutes HIV-related or preventable mortality, and their ambition is limited. This Position Paper presents consensus recommendations to define preventable HIV-related mortality for a pragmatic approach to public health monitoring by use of national HIV surveillance data. These recommendations were informed by a comprehensive literature review and agreed by 42 international experts, including clinicians, public health professionals, researchers, commissioners, and community representatives. By applying the recommendations to 2019 national HIV surveillance data from the UK, we show that 30% of deaths among people with HIV were HIV-related or possibly HIV-related, and at least 63% of these deaths were preventable or potentially preventable. The application of these recommendations by health authorities will ensure consistent monitoring of HIV elimination targets and allow for the identification of inequalities and areas for intervention