99 research outputs found
Topological entropy for some isotropic cosmological models
The chaotical dynamics is studied in different Friedmann-Robertson- Walker
cosmological models with scalar (inflaton) field and hydrodynamical matter. The
topological entropy is calculated for some particular cases. Suggested scheme
can be easily generalized for wide class of models. Different methods of
calculation of topological entropy are compared.Comment: Final version to appear in Phys. Rev D. Minor changes, typos
corrected; 29 pages with 2 eps figure
High Impact of Pediatric Inflammatory Bowel Disease on Caregivers’ Work Productivity and Daily Activities:An International Prospective Study
Induction of tolerance to desiccation and to subzero temperatures in embryos of recalcitrant seeds of inga
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals
J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe
Influence of the polyamines spermine and spermidine on yeast tRNAphe as revealed from its imino proton NMR spectrum
The effects of two synthetic putrescine analogues on germination and appressorium formation by uredospores of Uromyces viciae-fabae on artificial membranes
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