Handheld Standoff Mine Detection System (HSTAMIDS) Operational Field Evaluation in Cambodia

Handheld Standoff Mine Detection System (HSTAMIDS) Operational Field Evaluation in Cambodi

A digital solution to improve communication efficiency between environmental sensors and webservers (the osd2ERDDAP API).

The purpose of this report is to document the communications protocol and test system osd2ERDDAP developed as part of the Enhancing Climate Observations, Models and Data (ECO MAD) project. The approach allows deployed sensors to telemeter small quantities of arbitrary tabular Ocean Science Data (osd) directly to an ERDDAP server via the Internet in a way that is more efficient for the sensor than using ERDDAP’s existing HTML Forms interface. ERDDAP is a data server that provides a simple and consistent way to download subsets of scientific datasets in common file formats and make graphs and maps. It is the online server used by the British Oceanographic Data Centre (BODC) and National Oceanic and Atmospheric Administration (NOAA) to publicly share environmental data in a format that meets international data management standards. Future use of this API with a range of ocean sensors and ERDDAP will increase the efficiency of data streaming. In turn this reduces power (and associated maintenance) requirements that is vital to deliver low-cost long-term monitoring networks, which support climate research and the management of climate impacts

Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human Plasmodium falciparum Infections.

The majority of malaria infections in low transmission settings remain undetectable by conventional diagnostics. A powerful model to identify antibody responses that allow accurate detection of recent exposure to low-density infections is controlled human malaria infection (CHMI) studies in which healthy volunteers are infected with the Plasmodium parasite. We aimed to evaluate antibody responses in malaria-naïve volunteers exposed to a single CHMI using a custom-made protein microarray. All participants developed a blood-stage infection with peak parasite densities up to 100 parasites/μl in the majority of participants (50/54), while the remaining four participants had peak densities between 100 and 200 parasites/μl. There was a strong correlation between parasite density and antibody responses associated with the most reactive blood-stage targets 1 month after CHMI (Etramp 5, GLURP-R2, MSP4 and MSP1-19; Spearman's ρ = 0.82, p < 0.001). Most volunteers developed antibodies against a potential marker of recent exposure: Etramp 5 (37/45, 82%). Our findings justify validation in endemic populations to define a minimum set of antigens needed to detect exposure to natural low-density infections

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe

Transit Signal Priority: Current State of the Practice

Public transit buses face many operational challenges—especially when operating on the same streets and roads as other vehicles. Buses can be slowed by traffic congestion and get repeatedly caught at traffic lights, slowing buses down and delaying both passengers on board and passengers waiting at stops farther along the route. The TRB Transit Cooperative Research Program\u27s TCRP Synthesis 149: Transit Signal Priority: Current State of the Practice documents the current practice of TSP, which is an important tool that increases bus speeds and reliability, thereby improving transit system efficiency and effectiveness. Twenty-eight (61%) of the 46 surveyed transit agencies had active TSP deployments, and 13 transit agencies (28%) either are in predeployment testing or have plans to pursue TSP in the future

Composers Forum Spring Concert

https://dc.ewu.edu/music_performances/1803/thumbnail.jp