6 research outputs found
Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines
- Author
- Publication venue
- 'Dove Medical Press Ltd.'
- Publication date
- 01/04/2019
- Field of study
Wiwin Is Effendi,1,2 Tatsuya Nagano,1 Motoko Tachihara,1 Kanoko Umezawa,1 Tatsunori Kiriu,1 Ryota Dokuni,1 Masahiro Katsurada,1 Masatsugu Yamamoto,1 Kazuyuki Kobayashi,1 Yoshihiro Nishimura11Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; 2Department of Pulmonology and Respiratory Medicine, Airlangga University Medical Faculty, Surabaya 60131, IndonesiaBackground: The combination of gemcitabine (GEM) and paclitaxel (PTX) was appealing for clinical exploration due to different mechanisms of action and partially non-overlapping toxicities.Purpose: The aim of this study was to elucidate a potential effect of this combination on the proliferation of two non-small cell lung cancer (NSCLC) cell lines, A549 and H520.Materials and methods: Cell lines were treated with GEM and PTX for 48 hours to evaluate the half maximal inhibitory concentration (IC50). To determine the combination index (CI), cell lines were exposed to GEM and PTX, in a constant ratio of IC50, by various combination treatments. GEM`s effect on tubulin was assessed by western blotting and immunofluorescent staining. GEM was combined with nanoparticle albumin-bound-paclitaxel (NP) in evaluating tumor growth inhibition.Results: The IC50 of GEM and PTX in A549 and H520 were 6.6 nM and 46.1 nM, and 1.35 nM and 7.59 nM, respectively. Among the sequences explored (GEM→PTX, PTX→GEM, and GEM plus PTX simultaneously [GEM+PTX]), GEM→PTX produced a mean CI <1 in both cell lines. Western blotting and immunofluorescent staining revealed the intention expressions of acetylated tubulin protein and enhancement of tubulin polymerization within GEM→PTX group. A combination order GEM→NP also worked synergistically to suppress tumor growth.Conclusion: The GEM→PTX sequence may represent a promising candidate regimen for the treatment of NSLCL.Keywords: IC50, combination index, tubuli
Isolation and characterization of lignin from the oak wood bioethanol production residue for adhesives
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Synthesis and Biological Activities of 4H-3,1-Benzothiazin-4-Ones
- Author
- A Basheer
- A Krantz
- A Stößel
- B Mathew
- EP Papadopoulos
- F-R Alexandre
- G Tarzia
- H-G Häcker
- J Hanusek
- J Matysiak
- J Matysiak
- J Matysiak
- J Matysiak
- J Perronnet
- J Reynisson
- KA Jacobson
- L Legrand
- Lan Phuong Vu
- LR Lin
- M GĂĽtschow
- M GĂĽtschow
- Michael GĂĽtschow
- PA Ottersbach
- PA Ottersbach
- S Blättermann
- S Leistner
- S Leistner
- SL Badshah
- TA Khlosy
- U Neumann
- VPRK Putta
- W Thiel
- WD Dean
- WI Effendi
- Z-W Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Hydrothermal processing of biomass for anaerobic digestion – A review
- Author
- Abramson
- Adekunle
- Ahring
- Aita
- Akhtar
- Albarelli
- Alexandropoulou
- Almeida
- Alonso
- Amin
- Anna
- Arreola-Vargas
- Bach
- Barakat
- Barlow
- Beal
- Benavente
- Berge
- Berlin
- Beslin
- Bhagia
- Bohutskyi
- Bolado-RodrĂguez
- Bonawitz
- Bonn
- Bouchard
- Brunner
- Brunner
- Canilha
- Carrere
- Carvalheiro
- Carvalheiro
- Cellulose
- Chandel
- Chandel
- Chandra
- Chandra
- Chen
- Chum
- Clark
- Costa
- Costa
- Cybulska
- da Cruz
- de Moutta
- De Vrieze
- Deguchi
- Delgenes
- Deng
- Ding
- Donohoe
- Ebringerová
- Edson Luiz Silva
- Effendi
- Eggeman
- El Hage
- Elliott
- Eseyin
- Fan
- Fang
- Fang
- Fedorak
- Fengel
- Fernandez-Cegri
- Ferreira
- Fiaz Ahmad
- Franck
- Garrote
- Garrote
- Garrote
- Ge
- Ge
- Ghasimi
- Giuseppe
- Gollakota
- González
- Grimaldi
- Gubicza
- Guilliams
- GullĂłn
- Hansen
- Harris
- He
- He
- Heather
- Heilmann
- Hendriks
- Himmel
- Hirajima
- Hoekman
- Hon
- Huber
- Humbird
- Huttermann
- Ibbett
- Iqbal
- Isikgor
- Iwona
- Jansson
- Jian
- Jiao
- Jörn
- Kamali
- Kang
- Kaparaju
- Karimi
- Kelleher
- Keymer
- Kim
- Kleerebezem
- Knežević
- Ko
- Ko
- Kobayashi
- Koponen
- Kristensen
- Kruse
- Kumar
- Kumar
- Kumar
- Li
- Li
- Li
- Li
- Li
- Lilis
- Liu
- Liu
- Liu
- Liu
- Liu
- Lizasoain
- Lu
- Lucia
- Lucian
- Luterbacher
- Luterbacher
- Ma
- Ma
- Mainka
- Marasabessy
- Maria Bernadete Amâncio Varesche
- McCann
- McKennedy
- Melts
- Menardo
- Mendez
- Michalska
- Michalska
- Miller
- Mirmohamadsadeghi
- Mittal
- Mok
- Mok
- Monlau
- Mosier
- Möller
- Nges
- Nie
- Nitsos
- Nitsos
- O-Thong
- Oreggioni
- Overend
- Overend
- Palmqvist
- Passos
- Pedersen
- Pimentel
- PĂ©rez
- Qian
- Qiao
- Qing
- Quéméneur
- Richard
- Rivas
- Rocha
- Rodriguez Correa
- RomanĂ
- Rosatella
- Rossner
- Rowel
- Ruiz
- Ruiz
- Ruiz
- Saake
- Saha
- Saha
- Sakaki
- Sakar
- Sambusiti
- Scholz
- Senila
- Sevilla
- Shen
- Si
- Singh
- Sipponen
- Soccol
- Stagner
- Sun
- Sun
- Sun
- Sun
- Taherzadeh
- Tamaki
- Tanjore
- Tartakovsky
- Temiz
- Thomsen
- Towler
- Trajano
- Tsapekos
- Tzanetis
- Uzuner
- Vek
- Vivekanand
- Viéitez
- Waldner
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- Ward
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- Yoshida
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- Zakaria
- Zeng
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhao
- Zhao
- Zhou
- Zhu
- Zieminski
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Lipid signalling in plant responses to abiotic stress
- Author
- Abd-El-Haliem
- Alden
- Alvarez-Venegas
- Andersson
- Andreou
- Anthony
- Anthony
- Arisz
- Arisz
- Awai
- Bak
- Balla
- Balogh
- Bargmann
- Berdy
- Berkey
- Bi
- Blancaflor
- Boss
- Bunney
- Burnette
- Buseman
- Camoni
- Chapman
- Chapman
- Chen
- Chini
- Cortez-Espinosa
- Coursol
- D'Arrigo
- Darwish
- De Domenico
- De Jong
- Deak
- Delage
- DeWald
- Di Paolo
- Ding
- Distéfano
- Distéfano
- Dombrecht
- Dove
- Draczkowski
- Drøbak
- Du
- Dubots
- Durand
- Dutilleul
- Effendi
- Elge
- Eriksson
- Fahy
- Finka
- Frank
- Franklin-Tong
- Gao
- Gao
- Gasulla
- Gault
- Gillaspy
- Gou
- Grebner
- Griffiths
- Guillas
- Guo
- Guo
- Guo
- Hanada
- Hannun
- Harwood
- Heilmann
- Hong
- Hu
- Huang
- Hurlock
- Im
- Imbusch
- Ischebeck
- Ischebeck
- Jost
- Julkowska
- Julkowska
- Kang
- Karplus
- Kassas
- Katagiri
- Khodakovskaya
- Kim
- Kleinschmidt
- Klimecka
- Koag
- Koag
- Kooijman
- Kramell
- Kudo
- König
- König
- Köster
- Lachaud
- Larsson
- Lee
- Lee
- Lemtiri-Chlieh
- Li
- Li
- Li
- Liang
- Lynch
- LĂłpez-Bucio
- LĂłpez-Bucio
- Ma
- Mandal
- Markham
- McKinney
- McLoughlin
- McLoughlin
- McLoughlin
- Meijer
- Meijer
- Meijer
- Memon
- Merrill
- Meyer zu Heringdorf
- Min
- Mishkind
- Mishra
- Monreal
- Montillet
- Morquecho-Contreras
- Mosblech
- Mueller
- Munnik
- Munnik
- Munnik
- Mène-Saffrané
- MĂ©ndez-Bravo
- Nakashima
- Narayan
- Narváez-Vásquez
- Ndamukong
- Ng
- Nguyen
- Nováková
- Ohlrogge
- Ollas
- Pata
- Perera
- Petersen
- Pike
- Pleskot
- Poccia
- Pohl
- PotockĂ˝
- Preuss
- Pribat
- Rajashekar
- Rivera
- Roach
- Roston
- Ruelland
- Ruelland
- Sagaram
- Sanchez
- Sanders
- Sarkes
- Saucedo-GarcĂa
- Savchenko
- Scherer
- Scherer
- Schmid
- Seltmann
- Sheard
- Sheng
- Shi
- Simanshu Dhirendra
- Simons
- Spassieva
- Stevenson
- Stintzi
- Stotz
- Szumlanski
- Taddese
- Taki
- Tan
- Teaster
- Testerink
- Testerink
- Testerink
- Testerink
- Thiel
- Thines
- Thole
- Thoma
- Tsegaye
- Tsui
- Tumlinson
- Upchurch
- Uraji
- Urano
- Van Leeuwen
- Vaultier
- Vergnolle
- Vermeer
- Vicogne
- Viehweger
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Welti
- West
- Wi
- Wielandt
- Williams
- Williams
- Worrall
- Worrall
- Xiong
- Yang
- Yao
- Yu
- Zegzouti
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhao
- Zhong
- Publication venue
- 'Wiley'
- Publication date
- Field of study
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- R. Kaplinsky
- R. L. Hu
- R. L. u. Bamberger
- R. Langhammer
- R. Lohrmann
- R. M. Adams
- R. Matthew
- R. O. u. Keohane
- R. O. u. Keohane
- R. O. u. Keohane
- R. P. Neilson
- R. Parkers
- R. R. Nemani
- R. Reuveny
- R. Tetzlaff
- R. u. Black
- R. u. Daughters
- R. u. Leemans
- R. u. LĂ©tolle
- R. u. Matthew
- R. u. NordĂĄs
- R. u. Zhang
- Rabobank
- Reuters Foundation
- Reuters Foundation
- S. A. Hansen
- S. A. u. Cowling
- S. Bauer
- S. Bremer
- S. C. Coplin
- S. Castles
- S. Dalby
- S. Dalby
- S. Faris
- S. Gates
- S. Hensell
- S. I. Seneviratne
- S. Jasanoff
- S. Jasanoff
- S. Jones
- S. Kröhnert
- S. L. Kaplan
- S. Lindemann
- S. Lonergan
- S. Mainwaring
- S. Neubert
- S. P. Huntington
- S. P. Huntington
- S. P. Long
- S. Rahmstorf
- S. Rahmstorf
- S. S. Ali
- S. Schmeidl
- S. u. Bauer
- S. u. Chaudhuri
- S. u. Grimm
- S. u. Hitz
- S. u. Klingebiel
- S. u. Klingebiel
- S. u. Neubert
- S. Weinlich
- SATP — South Asia Terrorism Portal
- Senat der Bundesforschungsanstalten im Geschäftsbereich des Bundesministeriums für Verbraucherschutz Ernährung und Landwirtschaft
- SEPA — State Environmental Protection Administration
- SIPRI — Stockholm International Peace Research Institute
- Study Group on Europes Security Capabilities
- SĂĽdasien Info
- T. A. Scambos
- T. Barker
- T. Chatel
- T. D. Mitchell
- T. Debiel
- T. F. Homer-Dixon
- T. F. Homer-Dixon
- T. F. Homer-Dixon
- T. F. Homer-Dixon
- T. F. Homer-Dixon
- T. Faist
- T. G. Falleti
- T. Hagmann
- T. L. Root
- T. P. Barnett
- T. Prugh
- T. R. Gurr
- T. Risse
- T. Sterzel
- T. Trotha von
- T. u. Addison
- T. u. Heberer
- T. u. Heberer
- T. u. Oki
- T. Winter von
- U. B. Barkmann
- U. Grote
- U. Halbach
- U. Menzel
- U. Schneckener
- U. Scholz
- UK Foreign & Commonwealth Office
- UN DESA — United Nations Department of Economic and Social Affairs
- UN DESA — United Nations Department of Economic and Social Affairs
- UN Millennium Project
- UN — United Nations
- UN — United Nations
- UN — United Nations
- UN — United Nations
- UN — United Nations
- UNCCD — United Nations Convention to Combat Desertification
- UNCTAD — United Nations Conference on Trade and Development
- UNDP — United Nations Development Programme
- UNDP — United Nations Development Programme
- UNDP — United Nations Development Programme
- UNDP — United Nations Development Programme
- UNDP — United Nations Development Programme
- UNEP — United Nations Environment Programme
- UNEP — United Nations Environment Programme
- UNEP — United Nations Environment Programme
- UNEP — United Nations Environment Programme
- UNESCO — United Nations Educational Scientific and Cultural Organization
- UNESCO — United Nations Educational Scientific and Cultural Organization
- UNFPA — United Nations Population Fund
- UNHCR — United Nations High Commissioner for Refugees
- UNHCR — United Nations High Commissioner for Refugees
- UNHCR — United Nations High Commissioner for Refugees
- UNISDR — United Nations International Strategy for Disaster Reduction
- UNISDR — United Nations International Strategy for Disaster Reduction
- UNPD — United Nations Population Division
- UNPD — United Nations Population Division
- UNSG — United Nations Secretary General
- UNU-EHS — United Nations University Institute For Environment And Human Security
- USDA — U.S. Department of Agriculture Natural Resources Conservation Service
- USGS — U.S. Geological Survey
- V. Castel du
- V. E. Fuentes
- V. R. Burkett
- V. Smakhtin
- V. u. Percival
- W. A. V. Clark
- W. Abel
- W. Behringer
- W. Brandt
- W. H. Schlesinger
- W. J. u. Cosgrove
- W. P. u. Avery
- W. Thuiller
- W. u. Bauernfeind
- W. u. Hauge
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WBGU — Wissenschaftlicher Beirat Globale Umweltveränderungen
- WCD — World Commission on Dams
- White House
- White House
- WHO — World Health Organisation und UNICEF — United Nations Childrens Fund
- WI — Wuppertal Institut
- WI — Wuppertal Institut
- World Bank
- World Bank
- World Bank
- World Bank
- World Bank
- World Bank
- World Bank
- World Bank
- Worldwatch Institute
- Worldwatch Institute
- WTO — World Trade Organisation Committee on Agriculture
- WTO — World Trade Organisation Committee on Agriculture
- WTO — World Trade Organisation Committee on Agriculture
- WWF — World Wide Fund
- X. J. Gao
- X. Lan
- Y. Bangert
- Z. Brzezinski
- Z. Karaev
- Z. u. Brzezinski
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study