Electromagnetic Compatibility (EMC) Evaluation of a Prototype Solar-Charged Electric Race-Car

This technical report presents and analyses measured results of the electromagnetic compatibility (EMC) profile of a prototype solar-charged electric race-car during driving and charging conditions. Laboratory measurements and setups were based on CISPR 12 and IEC 61851-21-1 automotive EMC standards and on non-legislative exploratory EMC test methodologies, developed by the EC’s JRC. Results and main findings of more than 100 different setups managed on VeLA 9 validated automotive EMC semi-anechoic chamber, are methodologically extracted from measured data and analysed. The basis of this scientific activity was established to fulfil the objectives of the Interoperability and Electromagnetic Compatibility of Electric Vehicles and their Charging Infrastructure Work Package (WPK INTEC 6311) under the INTEROP-STORE Project (PRJ 208), in collaboration with Bochum University of Applied Sciences, Germany.JRC.C.4-Sustainable Transpor

Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma

Background: Chromosomal instability (CIN) has repeatedly been identified as a prognostic marker. Here we evaluated the percentage of aberrant genome per cell (PAG) as a measure of CIN in single disseminated tumour cells (DTC) isolated from patients with operable oesophageal adenocarcinoma (EAC), to assess the impact of CINhigh DTCs on prognosis. Methods: We isolated CK18(positive) DTCs from bone marrow (BM) or lymph node (LN) preparations of operable EAC patients. After whole-genome amplification, single DTCs were analysed for chromosomal gains and losses using metaphase-based comparative genomic hybridisation (mCGH). We calculated the PAG for each DTC and determined the critical threshold value that identifies high-risk patients by STEPP (Subpopulation Treatment Effect Pattern Plot) analysis in two independent EAC patient cohorts (cohort #1, n = 44; cohort # 2; n = 29). Results: The most common chromosomal alterations observed among the DTCs were typical for EAC, but the DTCs showed a varying PAG between individual patients. Generally, LNDTCs displayed a significantly higher PAG than BMDTCs. STEPP analysis revealed an increasing PAG of DTCs to be correlated with an increased risk for short survival in two independent EAC cohorts as well as in the corresponding pooled analysis. In all three data sets (cohort # 1, cohort # 2 and pooled cohort), PAG(high) DTCs conferred an independent risk for a significantly decreased survival. Conclusions: The analysis of PAG/CIN in solitary marker-positive DTCs identifies operable EAC patients with poor prognosis, indicating a more aggressive minimal residual disease