Probing compressed mass spectra in electroweak supersymmetry with Recursive Jigsaw Reconstruction

The lack of evidence for the production of colored supersymmetric particles at the LHC has increased interest in searches for superpartners of the electroweak SM gauge bosons, namely the neutralinos and charginos. These are challenging due to the weak nature of the production process, and the existing discovery reach has significant gaps in due to the difficulty of separating the supersymmetric signal from SM diboson events that produce similar final states and kinematics. We apply the Recursive Jigsaw Reconstruction technique to study final states enriched in charged leptons and missing transverse momentum, focusing on compressed topologies with direct production of charginos and neutralinos decaying to the lightest neutral supersymmetric particle through the emission of W and Z bosons. After presenting prototype analysis designs for future LHC runs, we demonstrate that its detectors have the potential to probe a significant amount of unexplored parameter space for chargino-neutralino associated production within the next few years, and show that the very challenging successful search for chargino pair production with compressed spectra might be possible by the end of the LHC lifetime.Comment: 20 pages, 33 figure

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner.

Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma. Herein we demonstrated that the TKI axitinib induces DNA damage response (DDR) characterized by γ-H2AX phosphorylation and Chk1 kinase activation leading to G2/M cell cycle arrest and mitotic catastrophe in U87, T98 and U251 glioma cell lines. Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment. Conversely, U251 cell line showed a resistant phenotype in response to axitinib treatment, as evidenced by cell cycle arrest but no sign of cell death. The combinatorial use of axitinib with other therapies, with the aim of inhibiting multiple signaling pathways involved in tumor growth, can increase the efficiency of this TKI. Thus, we addressed the combined effects of axitinib with no toxic doses of the proteasome inhibitor bortezomib on the growth of U87 and T98 axitinib- sensitive and axitinib-resistant U251 cell lines. Compared to single treatments, combined exposure was more effective in inhibiting cell viability of all glioma cell lines, although with different cell death modalities. The regulation of key DDR and cell cycle proteins, including Chk1, γ-H2AX and p21(Waf1/Cip1) was also studied in glioma cell lines. Collectively, these findings provide new perspectives for the use of axitinib in combination with Bortezomib to overcome the therapy resistance in gliomas

Has programmed trading made stock prices more volatile?

Futures ; Stock - Prices ; Stock market

Changes in wealth and the velocity of money

Gross national product ; Velocity of money ; Money supply ; Income

The great bull markets 1924-29 and 1982-87: speculative bubbles or economic fundamentals?

Stock market ; Stock - Prices

The Employment Act of 1946: some history notes

Employment Act of 1946 ; Full Employment and Balanced Growth Act of 1978 ; Unemployment

Product market integration and endogenous bargaining structure

This paper focuses on the effects of product market integration on wage-bargaining institutions in a one-way trade model of an international Cournot oligopoly. It shows that product market integration (i.e. a reduction in trade costs either from an arbitrary or from its optimal level) lowers the incentives to centralisation for home unions, given that firms always prefer decentralisation, making it more likely that a decentralised wage bargaining structure occurs in equilibrium.Bargaining institutions, unionised oligopolies, trade integration

How mucosal epithelia deal with stress: Role of NKG2D/NKG2D ligands during inflammation

Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions. Stressed and damaged cells need to be cleared to control local inflammation and trigger tissue healing. Engagement of the activating NKG2D receptor is one of the most direct mechanisms involved in the recognition of stressed cells by the immune system. Indeed, injured cells promptly express NKG2D ligands that in turn mediate the activation of lymphocytes of both innate and adaptive arms of the immune system. This review focuses on different conditions that are able to modulate NKG2D ligand expression on the epithelia. Special attention is given to the mechanisms of immunosurveillance mediated by natural killer cells, which are finely tuned by NKG2D. Different types of stress, including viral and bacterial infections, chronic inflammation, and cigarette smoke exposure, are discussed as paradigmatic conditions for NKG2D ligand modulation, and the implications for tissue homeostasis are discussed

The monetary control act, reserve taxes and the stock prices of commercial banks

Depository Institutions Deregulation and Monetary Control Act of 1980

Local area labor statistics- a phantom army of the unemployed?

Unemployment ; Regional economics