119 research outputs found
The Evolution of Compact Binary Star Systems
- Author
- A Ahmad
- A Blaauw
- A Bragaglia
- A Burrows
- A Burrows
- A Burrows
- A Büning
- A Cooray
- A Corongiu
- A Duquennoy
- A Gianninas
- A Heger
- A Kashi
- A Kusenko
- A Massevitch
- A Menon
- A Nebot Gómez-Morán
- A Noriega-Crespo
- A Noutsos
- A Palacios
- A Skumanich
- A Stroeer
- A Stroeer
- A Tornambé
- A Ulla
- A Wongwathanarat
- AA Zdziarski
- AC Fabian
- AE Rosenbush
- AG Kuranov
- AG Kuranov
- AG Lyne
- AG Lyne
- AG Lyne
- AG Massevich
- AG Massevitch
- AG Riess
- AH Prestwich
- AI Bogomazov
- AI Karakas
- AJ Farmer
- AJ Faulkner
- AJ Faulkner
- AJ Loveridge
- AJ Ruiter
- AJ Ruiter
- AJ Ruiter
- AJT Poelarends
- AL Kraus
- AL Piro
- AL Piro
- AL Piro
- AM Cherepashchuk
- AM Cherepashchuk
- AM Cherepashchuk
- AR King
- AR King
- AS Endal
- AS Oliveira
- AV Fedorova
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AW Hotan
- B Külebi
- B Külebi
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paxton
- B Paxton
- B Voss
- B Wang
- B Warner
- B Warner
- B Willems
- B Willems
- B Willems
- B Willems
- B-Q For
- BC Barish
- BD Mason
- BD Mason
- BD Metzger
- BE Schaefer
- BJ Shappee
- BJ Shappee
- BMS Hansen
- BP Flannery
- BS Sathyaprakash
- BT Gänsicke
- BT Hayden
- BW Ritchie
- C Badenes
- C Cutler
- C Foellmi
- C Georgy
- C Georgy
- C Georgy
- C Holcomb
- C Karl
- C Kim
- C Knigge
- C Knigge
- C Motch
- C Palenzuela
- C Raskin
- C Raskin
- C Ritossa
- C Weidner
- C-A Faucher-Giguère
- C-A Faucher-Giguère
- CA Whyte
- CD Bailyn
- CD Bailyn
- CJ Deloye
- CJ Philp
- CL Fryer
- CL Fryer
- CL Fryer
- CL Fryer
- CL Fryer
- CL Rodriguez
- CO Heinke
- CR Evans
- D Bhattacharya
- D Branch
- D Foss
- D Gerosa
- D Grossman
- D Hils
- D Hils
- D Ibeling
- D Kasen
- D Koester
- D Koester
- D Kushnir
- D Lai
- D Lai
- D Levitan
- D Lommen
- D Maoz
- D Prialnik
- D Prialnik
- D Prialnik
- D Raghavan
- D Schiminovich
- D Vanbeveren
- DA Dale
- DA Howell
- DJ Champion
- DJ Nice
- DJ Nice
- DL Kaplan
- DM Townsley
- DM Townsley
- DR Lorimer
- DW Schuerman
- E Bear
- E Berger
- E Cappellaro
- E Cappellaro
- E Donder De
- E Donder De
- E Donder De
- E Ergma
- E Ergma
- E García-Berro
- E Kuulkers
- E Livne
- E Livne
- E Nakar
- E Pfahl
- E Pfahl
- E Pfahl
- E Pylyser
- E Schatzman
- E Schatzman
- E-M Pauli
- EE Salpeter
- EF Keane
- EI Popova
- EI Popova
- EJ Lentz
- EL Robinson
- EL Robinson
- EM Green
- EM Sion
- EM Sion
- EM Sion
- EPJ Heuvel van den
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- ES Phinney
- F Acernese
- F Camilo
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- F Herwig
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- F Ozel
- F Ozel
- F Patat
- F Ricci
- F Verbunt
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- F Yuan
- FB Bianco
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- FS Kitaura
- FX Timmes
- FX Timmes
- G Duchêne
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- G Lü
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- G Nelemans
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- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Pandey
- G Ramsay
- G Ramsay
- G Stasińska
- G Tovmassian
- GE Brown
- GE Brown
- GE Soberman
- GH Tovmassian
- GHA Roelofs
- GHA Roelofs
- GJ Savonije
- GL Israel
- GP Kuiper
- GS Bisnovatyi-Kogan
- GS Bisnovatyi-Kogan
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- GS Bisnovatyi-Kogan
- H Belkus
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- HB Perets
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- HHB Lau
- HS Zapolsky
- I Brott
- I Dominguez
- I Domínguez
- I Domínguez
- I Hachisu
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- I Hachisu
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- I Iben Jr
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- I Idan
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- I Mandel
- IF Mirabel
- IF Mirabel
- IH Stairs
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- IR Seitenzahl
- IS Shklovskii
- J Abadie
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- J Boersma
- J Casares
- J Crowder
- J Faulkner
- J Faulkner
- J Fuller
- J Fuller
- J Girven
- J Guillochon
- J Isern
- J Isern
- J Liebert
- J Nordhaus
- J Papaloizou
- J Schwab
- J Smak
- J Whelan
- J-C Passy
- J-C Passy
- J-E Solheim
- J-E Solheim
- J-E Solheim
- J-P Lasota
- J-U Ness
- JA Edlund
- JA Freitas Pacheco de
- JA Frieman
- JA Orosz
- JA Orosz
- JA Orosz
- JA Orosz
- JB Lamb
- JC Lombardi Jr
- JCA Miller-Jones
- JDM Dewi
- JDM Dewi
- JE Faller
- JE Gunn
- JE McClintock
- JE McClintock
- JE Pringle
- JG Mengel
- JH Shiode
- JH Taylor
- JJ Drake
- JJ Hermes
- JJM Zand in’t
- JM Lattimer
- JM Lattimer
- JM Silverman
- JM Silverman
- JM Silverman
- JM Weisberg
- JM Weisberg
- JP Cox
- JP Greve De
- JPA Clark
- JPA Clark
- JR Hurley
- JR Hurley
- JR Maund
- JS Bloom
- JSW Claeys
- JW Truran
- JW Truran
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Hotokezaka
- K Lepo
- K Moore
- K Nomoto
- K Nomoto
- K Nomoto
- K Nomoto
- K Riles
- K Siellez
- K Somiya
- K Takahashi
- K Yagi
- K-C Pan
- KA Postnov
- KA Postnov
- KA Postnov
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KK Ghosh
- KM Blundell
- KS Thorne
- KS Thorne
- L Bildsten
- L Bildsten
- L Bildsten
- L Chomiuk
- L Chomiuk
- L Dessart
- L Guillemot
- L Kreidberg
- L Mahy
- L Mestel
- L Mestel
- L Piersanti
- L Piersanti
- L Piersanti
- L Piersanti
- L Siess
- L Siess
- L Siess
- L Trepl
- L-X Li
- LA Nelson
- LD Landau
- LD Landau
- LG Althaus
- LM Close
- LM Haaften van
- LM Haaften van
- LM Haaften van
- LP Grishchuk
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LZ Kelley
- M Bailes
- M Burgay
- M Burgay
- M Dan
- M Dan
- M Dan
- M Dominik
- M Dominik
- M Fink
- M Fukugita
- M Gilfanov
- M Gilfanov
- M Hamuy
- M Henze
- M Hicken
- M Ilkov
- M Kato
- M Kato
- M Kato
- M Kato
- M Kilic
- M Kilic
- M Kilic
- M Kool de
- M Kromer
- M Kromer
- M Livio
- M Livio
- M Nauenberg
- M Plavec
- M Politano
- M Reggiani
- M Rieutord
- M Rigault
- M Rigault
- M Tavani
- M Tsugawa
- M Val-Borro de
- M Yamanaka
- M Zorotovic
- M Zorotovic
- MA Ruderman
- MBN Kouwenhoven
- MBN Kouwenhoven
- MBN Kouwenhoven
- MCP Bours
- MCP Bours
- MCR D’Souza
- ME Alexander
- ME Beer
- ME Prokhorov
- MM Kasliwal
- MM Kasliwal
- MM Phillips
- MM Shara
- MM Shara
- MP Muno
- MR Bate
- MR Drout
- MS Hjellming
- MT Botticella
- MTB Nielsen
- MTB Nielsen
- MV Barkov
- MV Sluys van der
- N Andersson
- N Brandt
- N Chamel
- N Epelstain
- N Gehrels
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Langer
- N Langer
- N Panagia
- N Smith
- N Soker
- N Soker
- N Tominaga
- N Vranesevic
- N Wex
- N Yusof
- NI Shakura
- NJ Cornish
- NM Ashok
- NM Gosnell
- NN Chugai
- NN Chugai
- NN Chugai
- NR Tanvir
- NV Raguzova
- O Birnholtz
- O Graur
- O Graur
- O Marco De
- O Marco De
- O Schnurr
- O Yaron
- OF Dorofeev
- OR Pols
- P Amaro-Seoane
- P Amaro-Seoane
- P André
- P Astier
- P Bagot
- P Eggleton
- P Esposito
- P Gil-Pons
- P Hoeflich
- P Höflich
- P Kahabka
- P Kahabka
- P Lorén-Aguilar
- P Madau
- P Munar-Adrover
- P Podsiadlowski
- P Podsiadlowski
- P Podsiadlowski
- P Podsiadlowski
- P Rodríguez-Gil
- P Ruiz-Lapuente
- P Szypryt
- PA Crowther
- PA Crowther
- PA Crowther
- PA Denissenkov
- PA Woudt
- PA Woudt
- PC Peters
- PD Kiel
- PD Kiel
- PD Sackett
- PE Nugent
- PFL Maxted
- PG Jonker
- PG Pérez-González
- PJ Carter
- PJ Carter
- PJ Carter
- PJ Carter
- PL Bender
- PM Motl
- PM Ricker
- PM Ricker
- PP Eggleton
- R Canal
- R Canal
- R Canal
- R Chini
- R Fender
- R Giacconi
- R Mochkovitch
- R Moll
- R Morrison
- R Napiwotzki
- R Napiwotzki
- R Napiwotzki
- R Narayan
- R Narayan
- R O’Shaughnessy
- R Pakmor
- R Scalzo
- R Scalzo
- R Stefano Di
- R Stefano Di
- R Stefano Di
- R Takahashi
- R Tylenda
- R Voss
- R Waldman
- R Wesson
- RA Chevalier
- RA Chevalier
- RA Chevalier
- RA Chevalier
- RA Hulse
- RA Remillard
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- RA Wade
- RC Kennicutt
- RD Ferdman
- RE Falcon
- RE Taam
- RE Taam
- RE Williams
- RF Webbink
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- RF Webbink
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- RF Webbink
- RF Webbink
- RF Webbink
- RH Durisen
- RJ Dewey
- RJ Foley
- RJ Parker
- RK Kopparapu
- RL Barone-Nugent
- RLM Corradi
- RN Manchester
- RP Kraft
- RS Benson
- RW Romani
- RW Romani
- RW Sayer
- S Babak
- S Cassisi
- S Ekström
- S Fabrika
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Horiuchi
- S Ji
- S Johnston
- S Jones
- S Jones
- S Justham
- S Miyaji
- S Mohamed
- S Neo
- S Nissanke
- S Nissanke
- S Oslowski
- S Perlmutter
- S Rappaport
- S Rappaport
- S Rappaport
- S Refsdal
- S Repetto
- S Rosswog
- S Shah
- S Shah
- S Starrfield
- S Starrfield
- S Starrfield
- S Starrfield
- S Taubenberger
- S Toonen
- S Toonen
- S Vennes
- S Vereshchagin
- S Yu
- S Yu
- S-B Qian
- S-C Yoon
- S-C Yoon
- S-C Yoon
- S-C Yoon
- SA Colgate
- SA Sim
- SB Anderson
- SB Popov
- SC Vila
- SE Thorsett
- SE Timpano
- SE Woosley
- SE Woosley
- SE Woosley
- SF Portegies Zwart
- SF Portegies Zwart
- SF Portegies Zwart
- SH Lubow
- SL Larson
- SL Shapiro
- SN Shore
- SP Littlefair
- SS Kumar
- T Abel
- T Bulik
- T Dermine
- T Fragos
- T Kupfer
- T Linden
- T Linden
- T Nugis
- T Pan
- T Shahbaz
- T Wettig
- T-W Wong
- TA Prince
- TB Littenberg
- TE Woods
- TE Woods
- TE Woods
- TF Cartwright
- TJ Maccarone
- TM Tauris
- TM Tauris
- TM Tauris
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- U Heber
- V Gokhale
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- VA Brumberg
- VG Kornilov
- VG Kornilov
- VM Kaspi
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VN Mironovskii
- VS Petrov
- VV Davydov
- W Benz
- W Fong
- W Li
- W Li
- W-R Hamann
- WE Kerzendorf
- WE Kerzendorf
- WK Rose
- WM Farr
- WM Sparks
- WM Wolf
- WR Brown
- WR Brown
- X Meng
- X Wang
- X Zhang
- X-J Xu
- X-J Xu
- Y Osaki
- YA Fadeyev
- YA Fadeyev
- YB Zel’dovich
- YV Baryshev
- Z Barkat
- Z Han
- Z Han
- Z Han
- Z Han
- Z Han
- Z Kopal
- Z Li
- Z-W Liu
- ZW Liu
- ÉÉ Flanagan
- Publication venue
- 'Living Reviews'
- Publication date
- 03/01/2007
- Field of study
We review the formation and evolution of compact binary stars consisting of
white dwarfs (WDs), neutron stars (NSs), and black holes (BHs). Binary NSs and
BHs are thought to be the primary astrophysical sources of gravitational waves
(GWs) within the frequency band of ground-based detectors, while compact
binaries of WDs are important sources of GWs at lower frequencies to be covered
by space interferometers (LISA). Major uncertainties in the current
understanding of properties of NSs and BHs most relevant to the GW studies are
discussed, including the treatment of the natal kicks which compact stellar
remnants acquire during the core collapse of massive stars and the common
envelope phase of binary evolution. We discuss the coalescence rates of binary
NSs and BHs and prospects for their detections, the formation and evolution of
binary WDs and their observational manifestations. Special attention is given
to AM CVn-stars -- compact binaries in which the Roche lobe is filled by
another WD or a low-mass partially degenerate helium-star, as these stars are
thought to be the best LISA verification binary GW sources.Comment: 105 pages, 18 figure
The Near-Earth Object Surveyor Mission
- Author
- Abell Paul A.
- Bauer J. M.
- Bottke William
- Buratti Bonnie J.
- Carey Sean J.
- Cotto-Figueroa D.
- Cutri R. M.
- Dahlen D.
- Eisenhardt Peter R. M.
- Fernandez 6 Y. R.
- Furfaro Roberto
- Grav Tommy
- Hoffman T. L.
- Kelley Michael S.
- Kim Yoonyoung
- Kirkpatrick J. Davy
- Lawler Christopher R.
- Lilly Eva
- Liu X.
- Mainzer A. K.
- Marocco Federico
- Marsh K. A.
- Masci Frank J.
- Masiero Joseph R.
- McMurtry Craig W.
- Pourrahmani Milad
- Reinhart Lennon
- Ressler Michael E.
- Satpathy Akash
- Schambeau C. A.
- Sonnett S.
- Spahr Timothy B.
- Surace Jason A.
- Team NEO Surveyor Mission
- Vaquero Mar
- Wright E. L.
- Zengilowski Gregory R.
- Publication venue
- Publication date
- 19/10/2023
- Field of study
The Near-Earth Object (NEO) Surveyor mission is a NASA observatory designed
to discover and characterize near-Earth asteroids and comets. The mission's
primary objective is to find the majority of objects large enough to cause
severe regional impact damage (>140 m in effective spherical diameter) within
its five-year baseline survey. Operating at the Sun-Earth L1 Lagrange point,
the mission will survey to within 45 degrees of the Sun in an effort to find
the objects in the most Earth-like orbits. The survey cadence is optimized to
provide observational arcs long enough to reliably distinguish near-Earth
objects from more distant small bodies that cannot pose an impact hazard. Over
the course of its survey, NEO Surveyor will discover ∼200,000 - 300,000
new NEOs down to sizes as small as ∼10 m and thousands of comets,
significantly improving our understanding of the probability of an Earth impact
over the next century.Comment: accepted to PS
Microalgae biopeptides applied in nanofibers for the development of active packaging
- Author
- Alix S.
- Azeredo H. M. C.
- Azlin-Hasim S.
- Bazargani-Gilani B.
- Bhushani J. A.
- Brand-Williams W.
- Campos A.
- Ciardelli G.
- Collins G.
- Counsell J. N.
- Crackel R. L.
- Cían R. E.
- Duarte M. A. T.
- Ghasemi-Mobarakeh L.
- Goes A. M.
- Hoyle N. T.
- Johnson J.
- Kim M. S.
- Kim S. K.
- Korhonen H.
- Lisboa C. R.
- Martínez-Abad A.
- Mills S.
- Morais M. G.
- Morais M. G.
- Neo Y. P.
- Osawa C. C.
- Patrício T.
- Radha krishnan K.
- Ranjbar-Mohammadi M.
- Rhim J. W.
- Rufino M. S. M.
- Sheih I. C.
- Takala P. N.
- Wang X.
- Wu H. C.
- Wu J. C. C.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities
- Author
- A Joshi
- A LA Binch
- a S Htay
- A Schmocker
- A Thorvaldsson
- AA Marino
- AA Thorpe
- AT Reza
- AT Reza
- ATH Choy
- ATH Choy
- B Gantenbein-Ritter
- B Xu
- B Xu
- BH Wang
- BI Woods
- BJC Freeman
- BP Chan
- C Zhu
- C-Q Zhao
- CC Guterl
- CC Guterl
- CL Le Maitre
- D Denning
- D Puppi
- D Purmessur
- D Périé
- DDN Sun
- DF Coutinho
- DJ Aguiar
- DR Pereira
- E Alsberg
- EA Growney Kalaf
- EH Cassinelli
- ES Place
- F Wang
- G Chang
- G Crevensten
- G Feng
- G Khang
- G Pattappa
- G Vadalà
- GR Buttermann
- H Cheng
- H Tao
- H-J Wilke
- HA Lin
- J Berger
- J Naresh-Babu
- J Silva-Correia
- J Silva-Correia
- J Silva-Correia
- J Silva-Correia
- J Silva-Correia
- J Zhu
- JC Iatridis
- JD Thomas
- JF DeLucca
- JF Mano
- JL Bron
- JM Lee
- JP Jarman
- JP Thompson
- JPG Urban
- JS Temenoff
- JT Martin
- JT Martin
- JT Oliveira
- JT Oliveira
- JWS Hayami
- K Rezwan
- K Takahashi
- K-W Kim
- KD Hudson
- KL Spiller
- L Calderon
- L Jiang
- L Koepsell
- L Saad
- L Xin
- LA Nasto
- LJ Suggs
- LM Benneker
- LM Boyd
- M Endres
- M Likhitpanichkul
- M Sato
- M Yasen
- MB Coventry
- MC Cornejo
- MS Gupta
- MS Gupta
- N Bangel-Ruland
- N Wismer
- P Heneghan
- P Roughley
- P Schexnailder
- P-PA Vergroesen
- PB Malafaya
- PY Neo
- Q Guo
- R Chou
- RD Abbott
- RD Bowles
- RG Long
- S Roberts
- S Roberts
- S van Uden
- S Varghese
- S-H Park
- SBG Blanquer
- SCW Chan
- SK Leckie
- SM Mueller
- SM Richardson
- SM Richardson
- SR Van Tomme
- T Oner
- T Pirvu
- TK Chik
- V Stroganov
- WC Bae
- X Tang
- X Zhou
- Y Tao
- Y Wu
- Y-C Huang
- Z Fang
- Z Karimi
- Z Sun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2017
- Field of study
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance that progress to a chronic degeneration disease. Current biomedical treatments are not only ineffective in the long-run, but can also cause degeneration to spread to adjacent intervertebral discs. Regenerative strategies are desperately needed in the clinics, such as: minimal invasive nucleus pulposus or annulus fibrosus treatments, total disc replacement, and cartilaginous endplates decalcification.
Main Body: Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue engineering approaches. The premises for cell type and origin selection or even absence of cells is being explored. Choice of several raw materials and scaffold fabrication methods are evaluated. Extensive studies have been developed for fully regeneration of the annulus fibrosus and nucleus pulposus, together or separately, with a long set of different rationales already reported. Recent works show promising biomaterials and processing methods applied to intervertebral disc substitutive or regenerative strategies. Facing the abundance of studies presented in the literature aiming intervertebral disc regeneration it is interesting to observe how cartilaginous endplates have been extensively neglected, being this a major source of nutrients and water supply for the whole disc.
Conclusion: Severalinnovative avenues for tackling intervertebral disc degeneration are being reported â from acellular to cellular approaches, but the cartilaginous endplates regeneration strategies remain unaddressed. Interestingly, patient-specific approaches show great promise in respecting patient anatomy and thus allow quicker translation to the clinics in the near future.The authors would like to acknowledge the support provided by the Portuguese
Foundation for Science and Technology (FCT) through the project EPIDisc
(UTAP-EXPL/BBBECT/0050/2014), funded in the Framework of the “International
Collaboratory for Emerging Technologies, CoLab”, UT Austin|Portugal Program.
The FCT distinctions attributed to J. Miguel Oliveira (IF/00423/2012 and IF/01285/
2015) and J. Silva-Correia (IF/00115/2015) under the Investigator FCT program are
also greatly acknowledged.info:eu-repo/semantics/publishedVersio
Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis
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- AC Freitas de
- ADVM Jemal
- AS Huart
- CM Amaral
- CM Eischen
- EM Cortés-Malagón
- FE Paulin
- GL Bond
- J Momand
- J Momand
- J Son
- J Xiao
- J Zhang
- JD Oliner
- JM Walboomers
- JY Yang
- JY Yang
- K Münger
- L Chen
- L Wei
- LL Villa
- M Ashcroft
- M Gajjar
- M Renaux-Petel
- MA Lohrum
- O Nunobiki
- P Singhal
- PK Magnusson
- R Maya
- RS Tibbetts
- S Knappskog
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- S Knappskog
- S Knappskog
- SJ Neo
- SL Vargas-Torres
- SM Mendrysa
- SS Suh
- V Meissner Rde
- V Moreno
- VM Williams
- W Fu
- X Hu
- X Zhuo
- Y Zhao
- Z Goldberg
- ZX Xiao
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Global economic burden of unmet surgical need for appendicitis
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
- Stewart E
- Stewart H
- Stewart R
- Stickler E
- Stoddart MT
- Stokes E
- Stott G
- Strang S
- Stringer H
- Stringfellow TD
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- Xu Y
- Yahaya AA
- Yalamarthi S
- Yang DD
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- Yarham E
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- Yeung J
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- Youssef H
- Yu T
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- Zaat S
- Zanichelli D
- Zaver V
- Zeng R
- Zhang Y
- Zheleniakova T
- Zhu Y
- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
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- Abdelazeam AR
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- Abdelaziz MA
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- Abdelhady S
- Abdelhamed R
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- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
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- Elwy E
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- Elzayat I
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- Elzayyat I
- Elzowawi F
- Emadeldin D
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- Eng C
- English W
- Esam A
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- Espin-Basany E
- Espinoza F
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- Essam M
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- Evajelista CV
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- Farrugia A
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- Faruq A
- Fathy AM
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- Faturoti O
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- Faure A
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- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
- Author
- Aba M
- Abdellatif M
- Abdelmahmoud S
- Abu Hassan F
- Acil C
- Adarkwah P
- Adarraga J
- Adderley O
- Adefolaju A
- Afzal A
- Afzal Z
- Agarwal H
- Agnes A
- Agostinelli L
- Ahari D
- Ahmad H
- Ahmad R
- Ahmad S
- Ahmed N
- Ahmed N
- Ahmed WUR
- Ahmed WUR
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- Singh B
- Sinibaldi G
- Sinibaldi G
- Sinibaldi G
- Sisto G
- Sivanu K
- Skene E
- Slavchev M
- Slavchev M
- Slim N
- Slim N
- Smart N
- Smith I
- Smithers R
- Smolarek S
- Smyth S
- Soare C
- Soares AS
- Soares AS
- Soddu C
- Soh VWY
- Soldevila Verdeguer C
- Soldevila Verdeguer C
- Solinas L
- Sotiropoulos GC
- Sotiropoulos GC
- Spagni G
- Speake D
- Spencer G
- Spilsbury C
- Spilsbury C
- Spoletini D
- Spolverato G
- Sreenivasan S
- St F
- Stamopoulos P
- Stanley A
- Stark D
- Stark D
- Stavrinidou O
- Steinholt I
- Stewart EG
- Stokell C
- Stolcers K
- Stuart LM
- Suarez A
- Sundaralingam SS
- Sundaram Venkatesan G
- Suresh A
- Syllaios A
- Szal A
- Sánchez García C
- Tachezy M
- Tailor B
- Takar S
- Talal El-Abur I
- Talal El-Abur I
- Talal El-Abur I
- Tamini N
- Tamini N
- Tamini N
- Tan E
- Tan HWN
- Tan JY
- Tancredi M
- Tanis P
- Tanis P
- Tanna V
- Tansey M
- Tansey M
- Taser M
- Tatar OC
- Tatar OC
- Taubwurcel J
- Temperley H
- Tepe MD
- Testa V
- Thaker A
- Theodoropoulos C
- Theodorou D
- Theodorou D
- Thomas C
- Thomas T
- Thompson B
- Tiesi V
- Tijare C
- Ting A
- Tirimanna R
- Tirloni L
- Toh S
- Toh WH
- Tomara N
- Tomlin J
- Tonchev P
- Tone JF
- Tong KS
- Tonini V
- Top C
- Trapani R
- Tremlett A
- Triantafyllou A
- Triantafyllou T
- Triantafyllou T
- Trigiante G
- Trivedi R
- Troller R
- Troller R
- Troller R
- Trout I
- Trovato C
- Trujillo Díaz J
- Truskovs A
- Tsaparas P
- Tsimplis V
- Tsourouflis G
- Tulina I
- Tulina I
- Tuminello F
- Tuminello F
- Turhan AB
- Turner B
- Turner B
- Turri G
- Turri G
- Tutino R
- Tutino R
- Tzoumas N
- Tzoumas N
- Ugur M
- Ugur M
- Uhanowita Marage R
- Ular B
- Uprak TK
- Urbani A
- Urbieta A
- Usta MA
- Utkan NZ
- Utrilla Fornals A
- Utukuri M
- Uyar B
- V Vadiveloo T
- Vagios I
- Valiyeva S
- Valnarov-Boulter A
- van Dalen AS
- van de Ven A
- van de Ven A
- Van Straten S
- Vanalia P
- Varcada M
- Varghese C
- Vaselli NM
- Velez C
- Venturelli P
- Venturelli P
- Venturelli P
- Verlingieri V
- Vertaldi S
- Vetsa K
- Vicario Bravo M
- Vician M
- Vieira BN
- Vigna SA
- Vignotto C
- Villalonga B
- Virgilio E
- Viscosi F
- Vitish-Sharma P
- Vitish-Sharma P
- Vittori L
- Vladova P
- Vo UG
- Votava J
- Wagstaff A
- Walker B
- Walmsley A
- Walsh J
- Walter L
- Walters B
- Wang B
- Wang J
- Weiß C
- Wells CI
- Wenban C
- White C
- Whitehurst O
- Wilkins L
- Williams CY
- Williams G
- Williams J
- Willis L
- Wilson A
- Wise H
- Wong C
- Wong J Y
- Wong KHF
- Wright F
- Xu D
- Xu W
- Yalcinkaya A
- Yalcinkaya A
- Yang HW
- Yao L
- Yap SHK
- Yasin I
- Yates C
- Yates C
- Yek WY
- Yeo JY
- Yick C
- Yick C
- Yıldırım A
- Yogarajah T
- Yoldas T
- Yotsov T
- Yousaf H
- Yousuff M
- Yánez C
- Yüksel E
- Zabiyaka M
- Zafer F
- Zafer F
- Zaffaroni G
- Zagibová D
- Zagorac Z
- Zaheer M
- Zahid A
- Zahid M
- Zaidi M
- Zambon M
- Zammit-Maempel M
- Zanframundo C
- Zanni M
- Zayed M
- Zazza S
- Zeidan Z
- Zhang Y
- Zhu L
- Zhu X
- Ziolkowska K
- Ziolkowska K
- Zografos G
- Zonta S
- Çetin B
- Ölmez M
- Özbalcı GS
- Özen D
- Özen D
- Öztürk OU
- Čustović S
- Štefanová H
- Ευσταθίου Η
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
Repurposing of approved cardiovascular drugs
- Author
- A González-Pérez
- A Izadpanah
- AE Buhl
- AE Durazzo
- AF Lever
- AH Otake
- AH Wagner
- AK Sood
- AK Sood
- AM Algra
- ARB Trialists Collaboration
- B Bernard
- B Pasternak
- B Stenkvist
- B Stenkvist
- B Stenkvist
- B Vandewalle
- BL Devine
- BS Brooke
- BS Rao
- C Bosetti
- C Denoyelle
- C Espineda
- C Leaute-Labreze
- C Leaute-Labreze
- C Léauté-Labrèze
- C Pees
- C Quintavalle
- CH Choi
- CR Meier
- D Bansal
- D Herr
- D Jacobs
- D Sardana
- D Spiegel
- D Spiegel
- D Westaby
- DA Goldfarb
- DG Powe
- DL Weddle
- E Flossmann
- EA Olsen
- EA Platz
- EK Sloan
- ES Diaz
- EV Yang
- F Elefteriou
- F Gueler
- G Garcia-Tsao
- G Ronquist
- G Zang
- GA Kune
- GJ Gasic
- H Desai
- H Graf
- HC Diener
- HC Dietz
- HC Dietz
- HH Grytli
- HJ Song
- HM Wang
- I Sipahi
- J Avila
- J Bertrand
- J Bosch
- J Bukberg
- J Gribbin
- J Haux
- J Shao
- J Springer
- J Tumlin
- J-Q Chen
- JH Neo
- JJ Kolenich
- JL Roberts
- Jochen Springer
- JP Fryzek
- JP Habashi
- JR Emberson
- Junichi Ishida
- K Bielawski
- K Hindler
- K Masur
- K Okamoto
- KA Toulis
- L Blais
- LA Fleisher
- LA Lipsitz
- LH Lindholm
- LL Gluud
- M Groenink
- M Hogeling
- M Leoncini
- M Nesher
- M Tan
- M Thiele
- M-F Demierre
- Masaaki Konishi
- ME Lindsay
- MJ Thun
- MR Graaf
- MT Ruffin
- N Kawazoe
- Nicole Ebner
- O Shiratori
- OO Ogunwobi
- P Ducy
- P Hillon
- PA Ganz
- PB Raghavendra
- PC Elwood
- PH Thaker
- PK Lindenauer
- PM Ridker
- PM Rothwell
- PM Rothwell
- PM Rothwell
- Q Zhou
- R Anandanadesan
- R Franchis de
- R Yasumatsu
- RC Wester
- RE Moore
- RJ Biggar
- RJ Biggar
- RJ Groszmann
- RV Lacro
- S Friis
- S John
- S Kang
- S Lachgar
- S Lemeshow
- S Marsigliante
- S Pugh
- S Singh
- S Takeda
- S Yang
- SA Rajasekaran
- SD Silberstein
- SK Manna
- SM Kornblau
- T Poynard
- T Serste
- T Sjoberg
- T Suganuma
- TG Kreindler
- TI Barron
- TL Assimes
- TP Ahern
- V Sans
- VH Price
- W Schoner
- WC Lau
- WK Wu
- WL Smith
- X Li
- X-D Wu
- Y Chida
- Y Fujimoto
- Y Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …