70 research outputs found
Severe bilateral atrophy of the spinati muscles in a cadaver
During the routine dissection of a 62-year-old male cadaver, bilateral atrophy of
the supra and infraspinatus muscles was observed. The suprascapular nerves,
cervical spinal cord and surrounding muscles were found to be normal. We
propose that, in the face of normal histology and other normal shoulder girdle
muscles and normal nerves, this case represents an instance of Parsonage-Turner
syndrome. To our knowledge, this is the first report of bilateral spinati atrophy
in a cadaver
Unilateral agenesis of the facial artery with compensation by a giant transverse facial artery
During routine dissections carried out in the course of our medical gross anatomy
work, an unusual structure was found unilaterally on the left side of an adult
male cadaver. Upon investigation, this was determined to be a hugely dilated
transverse facial artery. Also noted was the complete absence of the ipsilateral
facial artery. To our knowledge, this is the first report of complete agenesis and
not simply diminution of the facial artery with compensatory enlargement of the
transverse facial artery
Rhetoric But Whose Reality? The Influence of Employability Messages on Employee Mobility Tactics and Work Group Identification
Over the last decade, employability has been presented by its advocates as the solution to employment uncertainty, and by its critics as a management rhetoric possessing little relevance to the experiences of most workers. This article suggests that while employability has failed to develop into a key research area, a deeper probing of its message is warranted. In particular, it is suggested that employability may have resonance with employees as workers rather than as employees of their immediate employing organisation. This demands a slightly different approach to studying employability than some other related phenomena such as employee commitment which has resonance only in relation to the employing organization. In adopting a social identity approach, the significance of the employability message is shown not only to lie in employeesâ willingness to disassociate from their existing work groups and pursue individual mobility, but also in its capacity to undermine workersâ collective responses to grievances and unwanted organizational changes. A future research agenda is presented which highlights the need to address recent attempts to develop employability expectations among graduate career entrants, and for a closer critical engagement with management writings that attempt to justify the unnecessary espousal of the self development message
High Density SNP Screen in A Large Multiplex Neural Tube Defect Family Refines Linkage to Loci at 7p21-Pter And 2q33.1-35
Neural tube defects (NTDs) are considered complex with both genetic and environmental factors implicated. To date, no major causative genes have been identified in humans despite several investigations. The first genomewide screen in NTDs (Rampersaud et al. 2005) demonstrated evidence of linkage to chromosomes 7 and 10. This screen included forty-four multiplex families and consisted of 402 microsatellite markers spaced approximately 10 cM apart. Further investigation of the genomic screen data identified a single large multiplex family, pedigree 8776, as primarily driving the linkage results on chromosome 7
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field
Midline intracranial cysts in identical twin brothers
Midline cysts of the anterior brain are common in infants e.g. cavum septum pellucidum et vergae. We report twin brothers with midline intracranial cysts, mildly increased ventricular size, and macrocephaly. One brother had a cavum septum pellucidum and vergae and the other a cavum septum pellucidum. With the obliteration of each brotherâs midline cyst the head circumference was noted to return to a normal head circumference curve and the ventricles decreased in size. We hypothesize that in infancy some cases of infantile macrocephaly are induced by a midline cyst and that as the cyst obliterates that physiologic cerebrospinal fluid pathways are established so that the head circumference returns within normal parameters. This knowledge should be kept in mind by the clinician who may wish to surgically intervene with a midline cyst prior to it demonstrating its natural history. Moreover, these data should especially be entertained in the premature infant. (J Pediatr Neurol 2004; 2(2): 107-110)
Ventral Brain Stem Compression in Pediatric and Young Adult Patients with Chiari I Malformations
- âŠ