Alternative societal solutions to pharmaceuticals in the aquatic environment

Environmental contamination with pharmaceuticals is widespread, inducing risks to both human health and the environment. This paper explores potential societal solutions to human and veterinary pharmaceuticals in the aquatic environment. To this end, we adopt transition research’s multi-level perspective framework, which allows us to understand the dynamics underlying pharmaceutical emissions and to recognize social and technical factors triggering change. Our qualitative analysis is based on data collected through literature research and interviews with actors from pharmaceutical industry, the health and agricultural sector. The research aims at identifying potential future solutions including requirements for as well as barriers to pathways leading to these solutions and describing the role of key actors involved. The three alternative societal solutions identified are: 1) accepting pharmaceuticals in the environment - substantial changes to the system are not required; 2) reconfiguring the current system by implementing various innovations that reduce pharmaceutical emissions; 3) fundamentally changing the current system to (largely) avoid pharmaceutical emissions. The paper further elicits societal, financial, organizational, regulatory and technological requirements that can facilitate implementation of these solutions. This work is novel as it constitutes a systemic view on all stages of the pharmaceutical lifecycle, comprehensively synthesizing options and measures along the entire lifecycle into societal solutions that are framed as transition pathways. Deriving societal solutions from key actor’s perspectives is innovative and provides insights to reflect on choices societies are going to have to make regarding pharmaceuticals in the environment.The authors gratefully thank interviewees who allocated time to answer interview questions, shared valuable insights and expressed opinions. Thanks to G. Niebaum for feedback after a trial interview and to E. Aukes for methodological advice. Brugnach’s contribution was partially supported by the Spanish Government’s María de Maeztu excellence accreditation (Ref. MDM-2017-0714 ). The authors acknowledge funding by the European Regional Development fund of the European Union under the INTERREG project MEDUWA-Vecht(e) (project number 142118)

Discovery of a Dust Sorting Process on Boulders Near the Reiner Gamma Swirl on the Moon

In a database of lunar fractured boulders (Rüsch & Bickel, 2023, https://doi.org/10.3847/psj/acd1ef), we found boulders with reflectance features dissimilar to previously known morphologies. We performed a photo-geologic investigation and determined that the features correspond to a dust mantling on top of boulders with a unique photometric behavior. We next performed a photometric model inversion on the dust mantling using Bayesian inference sampling. Modeling indicates that the dust photometric anomaly is most likely due to a reduced opposition effect, whereas the single scattering albedo is not significantly different from that of the nearby background regolith. This implies a different structure of the dust mantling relative to the normal regolith. We identified and discussed several potential processes to explain the development of such soil. None of these mechanisms can entirely explain the multitude of observational constraints unless evoking anomalous boulder properties. Further study of these boulders can shed light on the workings of a natural dust sorting process potentially involving dust dynamics, a magnetic field, and electrostatic dust transport. The presence of these boulders appears to be limited to the Reiner K crater near the Reiner Gamma magnetic and photometric anomaly. This close spatial relationship further highlights that poorly understood processes occur in this specific region of the Moon

Ring-Moat Dome Structures (RMDSs) in the Lunar Maria:Statistical, Compositional, and Morphological Characterization and Assessment of Theories of Origin

Ring-moat dome structures (RMDSs) are positive morphologic features found clustered across many mare regions on the Moon, of which only a few isolated examples have been previously reported. Our continuing survey has expanded the known locations of the RMDSs from ~2,600 to over 8,000, indicating that RMDSs are more common geological features than previously thought. This work presents a detailed geomorphological analysis of 532 RMDSs identified in several mare basins. The combination of detailed elemental mapping, morphological and morphometric analyses, spatial distribution relationships with other geologic structures, and comparison with terrestrial analogs lead us to conclude that (1) RMDSs represent low circular mounds with diameters of a few hundred meters (average about 200 m) and a mean height of 3.5 m. The mounds are surrounded by moats ranging from tens to over 100 m in width and up to several meters in depth; (2) there is a wide variation of titanium abundances, although RMDSs are more commonly found in mare regions of moderate-to-high titanium content (>3 wt% TiO2); (3) RMDSs are found to occur on or around fractures, graben, and volcanic edifices (small shields and cones); (4) a spatial association between RMDSs and Irregular Mare Patches (see Braden et al., 2014, https://doi.org/10.1038/ngeo2252) is observed, suggesting that both may form from related lava flows; (5) comparisons between RMDSs and lava inflationary structures on Earth support an inflation-related extrusive nature and a genetic relationship with host lava flow processes; and (6) RMDS embayment relationships with craters of different degradation ages superposed on the host mare, and regolith development models, produces conflicting age relationships and divide theories of RMDS origin into two categories, (1) synchronous with the emplacement and cooling of the host lava flows ~3–4 Ga and (2) emplaced substantially after the host mare lava unit, in the period ~0–3 Ga. We outline the evidence supporting this age conundrum and implications for the different theories of origin and describe future research avenues to help resolve these outstanding questions. ©2020. American Geophysical Union. All Rights Reserved

An integrated modelling approach to derive the grey water footprint of veterinary antibiotics

Water pollution by veterinary antibiotics (VAs) resulting from livestock production is associated with severe environmental and human health risks. While upward trends in global animal product consumption signal that these risks might exacerbate toward the future, VA related water pollution is currently insufficiently understood. To increase this understanding, the present research assesses processes influencing VA pollution from VA administration to their discharge into freshwater bodies, using an integrated modelling approach (IMA). For the VAs amoxicillin, doxycycline, oxytetracycline, sulfamethazine, and tetracycline we estimate loads administered to livestock, excretion, degradation during manure storage, fate in soil and transport to surface water. Fate and transport are modelled using the VA transport model (VANTOM), which is fed with estimates from the Pan-European Soil Erosion Risk Assessment (PESERA). The grey water footprint (GWF) is used to indicate the severity of water pollution in volumetric terms by combining VA loads and predicted no effect concentrations. We apply our approach to the German-Dutch Vecht river catchment, which is characterized by high livestock densities. Results show a VA mass load decrease larger than 99% for all substances under investigation, from their administration to surface water emission. Due to metabolization in the body, degradation during manure storage and degradation in soil, VA loads are reduced by 45%, 80% and 90% on average, respectively. While amoxicillin and sulfamethazine dissipate quickly after field application, significant fractions of doxycycline, oxytetracycline and tetracycline accumulate in the soil. The overall Vecht catchment's GWF is estimated at 250,000 m3 yr−1, resulting from doxycycline (81% and 19% contribution from the German and Dutch catchment part respectively). Uncertainty ranges of several orders of magnitude, as well as several remaining limitations to the presented IMA, underscore the importance to further develop and refine the approach

The Lunar Mare Ring-Moat Dome Structure (RMDS) Age Conundrum:Contemporaneous With Imbrian-Aged Host Lava Flows or Emplaced in the Copernican?

Ring-moat dome structures (RMDSs) are small circular mounds of diameter typically about 200 m and ∼3–4 m in height, surrounded by narrow, shallow moats. They occur in clusters, are widespread in ancient Imbrian-aged mare basalt host units and show mineralogies comparable to those of their host units. Based on these close associations and similarities, a model has been proposed for the formation of RMDS as the result of late-stage flow inflation, with second boiling releasing quantities of magmatic volatiles that migrate to the top of the flow as magmatic foams and extrude through cracks in the cooled upper part of the flow to produce the small RMDS domes and surrounding moats. In contrast to this model advocating a contemporaneous emplacement of RMDSs and their host lava flows, a range of observations suggests that the RMDS formed significantly after the emplacement and cooling of their host lava flows, perhaps as recently as in the Copernican Period (∼1.1 Ga to the present). These observations include: (a) stratigraphic embayment of domes into post-lava flow emplacement impact craters; (b) young crater degradation age estimates for the underlying embayed craters; (c) regolith development models that predict thicknesses in excess of the observed topography of domes and moats; (d) landform diffusional degradation models that predict very young ages for mounds and moats; (e) suggestions of fewer superposed craters on the mounds than on the adjacent host lava flows, and (f) observations of superposed craters that suggest that the mound substrate does not have the properties predicted by the magmatic foam model. Together, these observations are consistent with the RMDS formation occurring during the period after the extrusion and solidification of the host lava flows, up to and including the geologically recent Late Copernican, that is, the last few hundreds of millions of years of lunar history. We present and discuss each of these contradictory data and interpretations and summarize the requirements for magma ascent and eruption models that might account for young RMDS ages. We conclude with a discussion of the tests and future research and exploration that might help resolve the RMDS age and mode of emplacement conundrum

Optical techniques for 3D surface reconstruction in computer-assisted laparoscopic surgery

One of the main challenges for computer-assisted surgery (CAS) is to determine the intra-opera- tive morphology and motion of soft-tissues. This information is prerequisite to the registration of multi-modal patient-specific data for enhancing the surgeon’s navigation capabilites by observ- ing beyond exposed tissue surfaces and for providing intelligent control of robotic-assisted in- struments. In minimally invasive surgery (MIS), optical techniques are an increasingly attractive approach for in vivo 3D reconstruction of the soft-tissue surface geometry. This paper reviews the state-of-the-art methods for optical intra-operative 3D reconstruction in laparoscopic surgery and discusses the technical challenges and future perspectives towards clinical translation. With the recent paradigm shift of surgical practice towards MIS and new developments in 3D opti- cal imaging, this is a timely discussion about technologies that could facilitate complex CAS procedures in dynamic and deformable anatomical regions

Designing nanomaterials with desired mechanical properties by constraining the evolution of their grain shapes

Grain shapes are acknowledged to impact nanomaterials' overall properties. Research works on this issue include grain-elongation and grain-strain measurements and their impacts on nanomaterials' mechanical properties. This paper proposes a stochastic model for grain strain undergoing severe plastic deformation. Most models deal with equivalent radii assuming that nanomaterials' grains are spherical. These models neglect true grain shapes. This paper also proposes a theoretical approach of extending existing models by considering grain shape distribution during stochastic design and modelling of nanomaterials' constituent structures and mechanical properties. This is achieved by introducing grain 'form'. Example 'forms' for 2-D and 3-D grains are proposed. From the definitions of form, strain and Hall-Petch-Relationship to Reversed-Hall-Petch-Relationship, data obtained for nanomaterials' grain size and conventional materials' properties are sufficient for analysis. Proposed extended models are solved simultaneously and tested with grain growth data. It is shown that the nature of form evolution depends on form choice and dimensional space. Long-run results reveal that grain boundary migration process causes grains to become spherical, grain rotation coalescence makes them deviate away from becoming spherical and they initially deviate away from becoming spherical before converging into spherical ones due to the TOTAL process. Percentage deviations from spherical grains depend on dimensional space and form: 0% minimum and 100% maximum deviations were observed. It is shown that the plots for grain shape functions lie above the spherical (control) value of 1 in 2-D grains for all considered grain growth mechanisms. Some plots lie above the spherical value, and others approach the spherical value before deviating below it when dealing with 3-D grains. The physical interpretations of these variations are explained from elementary principles about the different grain growth mechanisms. It is observed that materials whose grains deviate further away from the spherical ones have more enhanced properties, while materials with spherical grains have lesser properties. It is observed that there exist critical states beyond which Hall-Petch Relationship changes to Reversed Hall-Petch Relationship. It can be concluded that if grain shapes in nanomaterials are constrained in the way they evolve, then nanomaterials with desired properties can be designed

Yang-Mills- and D-instantons

In these lectures, which are written at an elementary and pedagogical level, we discuss general aspects of (single) instantons in SU(N_c) Yang-Mills theory, and then specialize to the case of N = 4 supersymmetry and the large N_c limit. We show how to determine the measure of collective coordinates and compute instanton corrections to certain correlation functions. We then relate this to D-instantons in type IIB supergravity. By taking the D-instantons to live in an $AdS_5\times S^5$ background, we perform explicit checks of the AdS/CFT correspondence.Comment: 62 pages, typos corrected, table of contents and references adde

Sponge spicules as blueprints for the biofabrication of inorganic–organic composites and biomaterials

While most forms of multicellular life have developed a calcium-based skeleton, a few specialized organisms complement their body plan with silica. However, of all recent animals, only sponges (phylum Porifera) are able to polymerize silica enzymatically mediated in order to generate massive siliceous skeletal elements (spicules) during a unique reaction, at ambient temperature and pressure. During this biomineralization process (i.e., biosilicification) hydrated, amorphous silica is deposited within highly specialized sponge cells, ultimately resulting in structures that range in size from micrometers to meters. Spicules lend structural stability to the sponge body, deter predators, and transmit light similar to optic fibers. This peculiar phenomenon has been comprehensively studied in recent years and in several approaches, the molecular background was explored to create tools that might be employed for novel bioinspired biotechnological and biomedical applications. Thus, it was discovered that spiculogenesis is mediated by the enzyme silicatein and starts intracellularly. The resulting silica nanoparticles fuse and subsequently form concentric lamellar layers around a central protein filament, consisting of silicatein and the scaffold protein silintaphin-1. Once the growing spicule is extruded into the extracellular space, it obtains final size and shape. Again, this process is mediated by silicatein and silintaphin-1, in combination with other molecules such as galectin and collagen. The molecular toolbox generated so far allows the fabrication of novel micro- and nanostructured composites, contributing to the economical and sustainable synthesis of biomaterials with unique characteristics. In this context, first bioinspired approaches implement recombinant silicatein and silintaphin-1 for applications in the field of biomedicine (biosilica-mediated regeneration of tooth and bone defects) or micro-optics (in vitro synthesis of light waveguides) with promising results