33 research outputs found
FUNCTIONAL-CHARACTERISTICS OF THE RAT-LIVER MACROPHAGE POPULATION AFTER A SINGLE INTRAVENOUS-INJECTION OF LIPOSOME-ENCAPSULATED MURAMYL PEPTIDES
- Publication venue
- Publication date
- 01/05/1993
- Field of study
In this study, we investigated different functional characteristics of the rat liver macrophage population after a single i.v. injection of liposome-encapsulated muramyl dipeptide (MDP) or its lipophilic derivative muramyl tripeptide-phosphatidylethanolamine (MTP-PE). The in situ induced tumoricidal activity of the liver macrophage population was determined in vitro against C26 colon adenocarcinoma cells. For investigating which cells are responsible for the observed cytotoxic effects, subfractions of the liver macrophage population, differing in cell size, were isolated at different intervals after injection of the liposomal muramyl peptides. From these subfractions, the number of cells, degree of cytotoxicity, and the response to an additional activation with free MDP in vitro were determined. Maximal induction of tumoricidal activity of the liver macrophage population was reached between 12 and 24 hours after injection of liposomal MDP, while no significant differences between the subfractions were observed. Heterogeneity of tumor cytolytic capacity was observed in subfractions of macrophages isolated at 2 and 48 hours after injection. At these time points, highest cytolytic activity was observed for the small to intermediate-size macrophages. No significant cytotoxicity was detectable in any subfraction 72 hours after injection of liposomal MDP. An identical pattern of macrophage tumoricidal activity was observed after injection of liposomal MTP-PE, although slightly lower cytotoxicity levels were found. When isolated during the first 12 hours after injection of liposomal MDP, the macrophage population was unable to respond to a subsequent in vitro exposure to MDP, with respect to tumor cytotoxicity. Twenty-four and 48 hours after injection, the smallest cells could be slightly reactivated, whereas the larger cells still remained unresponsive. Seventy-two hours after injection, reactivating potential was only slightly decreased, compared with macrophages isolated from control animals. We observed an approximately two-fold increase in the number of isolated cells from 2 up to 24 hours after injection of liposomal MDP, mainly as a result of an increase in the number of cells in the small-cell fractions. At 2 hours after injection, this increase is mainly due to an increase in the number of granulocytes in these fractions, which coincides with an increase in the percentage of granulocytes in the blood at this time point. At 12 and 24 hours after injection, no granulocytes were observed in the different subfractions. The increase in the number of small-size cells at 12 and 24 hours after injection is accompanied by an increase in the percentage of monocytes in the blood at these time points. We conclude that it is likely that these cells play an important role in the cytotoxic potential of the liver, induced by liposomal muramyl peptides
FUNCTIONAL-CHARACTERISTICS OF THE RAT-LIVER MACROPHAGE POPULATION AFTER A SINGLE INTRAVENOUS-INJECTION OF LIPOSOME-ENCAPSULATED MURAMYL PEPTIDES
- Publication venue
- Publication date
- 01/05/1993
- Field of study
Identification of multidrug resistance-associated protein 1 and glutathione as multidrug resistance mechanisms in human prostate cancer cells: chemosensitization with leukotriene D4 antagonists and buthionine sulfoximine
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2004
- Field of study
ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2006
- Field of study
Daunorubicin and cytarabine with daunorubicin cytarabine and the MDR1 reversal agent PSC-833 in elderly patients with acute myelogenous leukemia
- Author
- Publication venue
- Publication date
- 01/01/2004
- Field of study
Daunorubicin and cytarabine with daunorubicin cytarabine and the MDR1 reversal agent PSC-833 in elderly patients with acute myelogenous leukemia
- Author
- Publication venue
- Publication date
- Field of study
The embryo as moral work object: PGD/IVF staff views and experiences
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- 'Wiley'
- Publication date
- 01/01/2008
- Field of study
Copyright @ 2008 the authors. This article is available in accordance with the Creative Commons Deed, Attribution 2.5, see http://creativecommons.org/licenses/by-nc-nd/2.5/deed.en_CA.We report on one aspect of a study that explored the views and experiences of practitioners and scientists on social, ethical and clinical dilemmas encountered when working in the field of preimplantation genetic diagnosis (PGD) for serious genetic disorders. The study produced an ethnography based on observation, interviews and ethics discussion groups with staff from two PGD/IVF Units in the UK. We focus here on staff perceptions of work with embryos that entails disposing of ‘affected’ or ‘spare’ embryos or using them for research. A variety of views were expressed on the ‘embryo question’ in contrast to polarised media debates. We argue that the prevailing policy acceptance of destroying affected embryos, and allowing research on embryos up to 14 days leaves some staff with rarely reported, ambivalent feelings. Staff views are under-researched in this area and we focus on how they may reconcile their personal moral views with the ethical framework in their field. Staff construct embryos in a variety of ways as ‘moral work objects’. This allows them to shift attention between micro-level and overarching institutional work goals, building on Casper's concept of ‘work objects’ and focusing on negotiation of the social order in a morally contested field.The Wellcome Trust Biomedical Ethics Programme, who funded the projects‘Facilitating choice, framing choice: the experience of staff working in pre-implantation genetic diagnosis’ (no: 074935), and ‘Ethical Frameworks for Embryo Donation:the views and practices of IVF/PGD staff’ (no: 081414)
Studies of the performance of the ATLAS detector using cosmic-ray muons
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- Yilmaz M
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- Publication venue
- Publication date
- 01/01/2011
- Field of study
Commissioning of the ATLAS Muon Spectrometer with cosmic rays
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Adorisio C
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahmed H
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Aktas A
- Alam MA
- Alam MS
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amelung C
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Andeen T
- Anders CF
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
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- Antonelli S
- Antos J
- Antunovic B
- Anulli F
- Aoun S
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin JF
- Argyropoulos T
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Arutinov D
- Asai M
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Auerbach B
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
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- Azuelos G
- Azuma Y
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- Bach AM
- Bachacou H
- Bachas K
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- Badescu E
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- Bai Y
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- Baines JT
- Baker MD
- Baker OK
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- Castro NF
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- Cerqueira AS
- Cerri A
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- Chapman JD
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- Charlton DG
- Chavda V
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- Chekulaev SV
- Chelkov GA
- Chen H
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- Chu ML
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- Ciapetti G
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- Cindro V
- Ciobotaru MD
- Ciocca C
- Ciocio A
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- Cogneras E
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- Colon G
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- Consonni M
- Constantinescu S
- Conta C
- Conventi F
- Cooke M
- Cooper BD
- Cooper-Sarkar AM
- Cooper-Smith NJ
- Copic K
- Cornelissen T
- Corradi M
- Correia AMH
- Corriveau F
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- Cortes-Gonzalez A
- Cortiana G
- Costa G
- Costa MJ
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- Costin T
- Cote D
- Courneyea L
- Cowan G
- Cowden C
- Cox BE
- Cranmer K
- Cranshaw J
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- Cristinziani M
- Crosetti G
- Crupi R
- Curatolo M
- Curtis CJ
- Curull XE
- Cwetanski P
- Czyczula Z
- D'Auria S
- D'Onofrio M
- D'Orazio A
- da Costa JBG
- Da Via C
- Dabrowski W
- Dai T
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- Dallison SJ
- Daly CH
- Dam M
- Damazio DO
- Danielsson HO
- Dannheim D
- Dao V
- Darbo G
- Darlea GL
- Davey W
- Davidek T
- Davidson N
- Davidson R
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- Davison AR
- Dawson I
- Daya RK
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- de Jong P
- de la Hoz SG
- de Lima JGR
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- De Regie JBD
- de Renstrom PAB
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- De Santo A
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- De K
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- Dedovich DV
- Degenhardt J
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- Del Papa C
- Del Peso J
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- Dell'Asta L
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- della Porta GZ
- della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Deng J
- Deng W
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- Derkaoui JE
- Derue F
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- Deviveiros PO
- Dewhurst A
- DeWilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
- Di Ciaccio L
- Di Domenico A
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Nardo R
- Di Simone A
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- Diaz MA
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- Dietrich J
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- Dolenc I
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- Ryan P
- Rybkin G
- Rzaeva S
- Saavedra AF
- Sadrozinski HFW
- Sadykov R
- Sakamoto H
- Salamanna G
- Salamon A
- Saleem MS
- Salgado PEDF
- Salihagic D
- Salnikov A
- Salt J
- Salvatore D
- Salvatore F
- Salvucci A
- Salzburger A
- Sampsonidis D
- Samset BH
- Sanchez J
- Sandaker H
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- Sanders MP
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- Sandhu P
- Sandstroem R
- Sandvoss S
- Sankey DPC
- Sanny B
- Sansoni A
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- Santonico R
- Saraiva JG
- Sarangi T
- Sarkisyan-Grinbaum E
- Sarri F
- Sasaki O
- Sasao N
- Satsounkevitch I
- Sauvage G
- Savard P
- Savine AY
- Savinov V
- Sawyer L
- Saxon DH
- Says LP
- Sbarra C
- Sbrizzi A
- Scannicchio DA
- Schaarschmidt J
- Schacht P
- Schaetzel S
- Schafer U
- Schaffer AC
- Schaile D
- Schamberger RD
- Schamov AG
- Schegelsky VA
- Scheirich D
- Schernau M
- Scherzer MI
- Schiavi C
- Schieck J
- Schioppa M
- Schlenker S
- Schmieden K
- Schmitt C
- Schmitz M
- Schott M
- Schouten D
- Schovancova J
- Schram M
- Schreiner A
- Schroeder C
- Schroer N
- Schroers M
- Schultes J
- Schultz-Coulon HC
- Schumacher JW
- Schumacher M
- Schumm BA
- Schune P
- Schwanenberger C
- Schwartzman A
- Schwemling P
- Schwienhorst R
- Schwierz R
- Schwindling J
- Scott WG
- Searcy J
- Sedykh E
- Segura E
- Seidel SC
- Seiden A
- Seifert F
- Seixasa JM
- Sekhniaidze G
- Seliverstov DM
- Sellden B
- Semprini-Cesaria N
- Serfon C
- Serin L
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- Severini H
- Sevior ME
- Sfyrla A
- Shabalina E
- Shamim M
- Shan LY
- Shank JT
- Shao QT
- Shapiro M
- Shatalov PB
- Shaw K
- Sherman D
- Sherwood P
- Shibata A
- Shimojima M
- Shin T
- Shmeleva A
- Shochet MJ
- Shupe MA
- Sicho P
- Sidoti A
- Siegert F
- Siegrist J
- Sijackia D
- Silbert O
- Silva J
- Silva MLG
- Silver Y
- Silverstein D
- Silverstein SB
- Simak V
- Simica L
- Simion S
- Simmons B
- Simonyan M
- Sinervo P
- Sinev NB
- Sipica V
- Siragusa G
- Sisakyan AN
- Sivoklokov SY
- Sjoelin J
- Sjursen TB
- Skovpen K
- Skubic P
- Slater M
- Slavicek T
- Sliwa K
- Sloper J
- Sluka T
- Smakhtin V
- Smirnov SY
- Smirnov Y
- Smirnova LN
- Smirnova O
- Smith BC
- Smith D
- Smith KM
- Smizanska M
- Smolek K
- Snesarev AA
- Snow J
- Snow SW
- Snuverink J
- Snyder S
- Soaresa M
- Sobie R
- Sodomka J
- Soffer A
- Soh DA
- Solans CA
- Solar M
- Solc J
- Solodkov AA
- Solovyanov OV
- Soluk R
- Sondericker J
- Sopko B
- Sopko V
- Sosebee M
- Soukharev A
- Spagnolo S
- Spano F
- Spencer E
- Spighia R
- Spigo G
- Spila F
- Spiwoks R
- Spousta M
- Spreitzer T
- Spurlock B
- St Denis RD
- Stahl T
- Stahlman J
- Stamena R
- Stancu SN
- Stanecka E
- Stanek RW
- Stanescua C
- Stapnes S
- Starchenko EA
- Stark J
- Staroba P
- Starovoitov P
- Stastny J
- Stavina P
- Steele G
- Steinbach P
- Steinberg P
- Stekl I
- Stelzer B
- Stelzer HJ
- Stelzer-Chilton O
- Stenzel H
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- Stradling AR
- Straessner A
- Strandberg J
- Strandberg S
- Strandlie A
- Strauss M
- Strizenec P
- Strohmer R
- Strom DM
- Stroynowski R
- Strube J
- Stugu B
- Su D
- Sugaya Y
- Sugimoto T
- Suhra C
- Suk M
- Sulin VV
- Sultansoy S
- Sumida T
- Sund XH
- Sundermann JE
- Suruliz K
- Sushkov S
- Susinno G
- Sutton MR
- Suzuki T
- Suzuki Y
- Sykora I
- Sykora T
- Szymocha T
- Ta D
- Tackmann K
- Taffard A
- Tafirout R
- Taga A
- Takahashi Y
- Takai H
- Takashima R
- Takeda H
- Takeshita T
- Talby M
- Talyshev A
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- Tanaka R
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- Teixeira-Dias P
- Ten Kate H
- Teng PK
- Tennenbaum-Katan YD
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- Terashi K
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- Testa M
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- Thoma S
- Thomas JP
- Thompson AS
- Thompson EN
- Thompson PD
- Thompson PD
- Thompson RJ
- Thomson E
- Thun RP
- Tic T
- Tikhomirov VO
- Tikhonov YA
- Tipton P
- Tisserant S
- Toczek B
- Todorov T
- Todorova-Nova S
- Toggerson B
- Tojo J
- Tokar S
- Tokushuku K
- Tollefson K
- Tomasek L
- Tomasek M
- Tomoto M
- Tompkins L
- Toms K
- Tonoyan A
- Topfel C
- Topilin ND
- Torregrosa EF
- Torrence E
- Torres RC
- Toth J
- Touchard F
- Tovey DR
- Trefzger T
- Tremblet L
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Trinh TN
- Tripiana MF
- Triplett N
- Trischuk W
- Trivedi A
- Trocme B
- Troncon C
- Trzupek A
- Tsarouchas C
- Tseng JCL
- Tsiakiris M
- Tsiareshka PV
- Tsionou D
- Tsipolitis G
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsung JW
- Tsuno S
- Tsybychev D
- Tuggle JM
- Turecek D
- Turlay E
- Tuts PM
- Twomey MS
- Tylmad M
- Tyndel M
- Uchida K
- Ueda I
- Ugland M
- Uhlenbrock M
- Uhrmacher M
- Ukegawa F
- Unal G
- Undrus A
- Unel G
- Unel MK
- Unno Y
- Urban SC
- Urbaniec D
- Urkovsky E
- Urquijo P
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- Vacavant L
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- Valentinetti S
- Valkar S
- Vallecorsa S
- Van Berg R
- van der Graaf H
- van der Kraaij E
- van der Poel E
- van der Ster D
- van Eldik N
- van Gemmeren P
- van Kesteren Z
- van Vulpen I
- Vandelli W
- Vaniachine A
- Vankov P
- Vannucci F
- Vaque FV
- Varia R
- Varnes EW
- Varouchas D
- Vartapetian A
- Varvell KE
- Vasilyeva L
- Vassilakopoulos VI
- Vazeille F
- Vellidis C
- Veloso F
- Veneziano S
- Ventura A
- Ventura D
- Venturi M
- Venturi N
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Vetterli MC
- Vichou I
- Vickey T
- Viegas FJTA
- Viehhauser GHA
- Villa M
- Villani EG
- Vilucchi E
- Vincter MG
- Vinek E
- Vinogradov VB
- Viret S
- Virzi J
- Vitale A
- Vitells O
- Vivarelli I
- Vlachos S
- Vlasak M
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- Walkowiak W
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- Weber MD
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- Weingarten J
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- Whittington D
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- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
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- Wiglesworth C
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- Williams HH
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- Wilson MG
- Wingerter-Seez I
- Winklmeier F
- Wittgen M
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- Wosiek BK
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- Wu X
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- Xaplanteris L
- Xella S
- Xie S
- Xu D
- Xu N
- Yagci KD
- Yamada M
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yang UK
- Yang Z
- Yao WM
- Yao Y
- Yasu Y
- Ye J
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- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
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- Zaidan R
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- Zemla A
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- Zenin O
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- Zenonos Z
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- Zhan Z
- Zhang H
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- Zhang Q
- Zhang X
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- Zhemchugov A
- Zhong J
- Zhou B
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- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
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- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zutshia V
- Publication venue
- Publication date
- 01/01/2010
- Field of study