Questionnaire assessment of the welfare of pigs

A questionnaire study was performed involving 76 farms with a total of 380,207 pigs to assess the welfare of pigs kept in Hungary based on the animal welfare legislation of the European Union. Most significant deficiencies were found in the fulfilment of the provisions relating to space requirements, the stall microclimate and the behavioural needs of the animals

Performance of the ALICE luminosity levelling software architecture in the Pb-Pb physics run

Luminosity leveling is performed in the ALICE experi-ment of the Large Hadron Collider (LHC) in order to limitthe event pile-up probability, and ensure a safe operation forthe detectors. It will be even more important during Run3 when 50 KHz Pb ion-Pb ion (Pb-Pb) collisions will bedelivered in IP2. On the ALICE side, it is handled by theALICE-LHC Interface project, which also ensures an onlinedata exchange between ALICE and the LHC. An automated luminosity leveling algorithm was developed for the proton-proton physics run, and was also deployed for the Pb-Pb run with some minor changes following experience gained. The algorithm is implemented in the SIMATIC WinCC SCADA environment, and determines the leveling step from measured beam parameters received from the LHC, and the luminosity recorded by ALICE. In this paper, the softwarearchitecture of the luminosity leveling software is presented,and the performance achieved during the Pb-Pb run and Vander Meer scans is discussed.peer-reviewe

Effect of operational parameters of microwave vacuum drying combined with hot-air pre-drying to physical, sensory, and nutritional properties of dried apple snack

Microwave vacuum drying is a novel and mild food preserving technology. Beside its basic preserving function, it can be combined with other technologies, like hot-air drying. As a result of this combination, special snack can be produced from apple. The product is characterized by its unique consistency, high nutritional value, and consumer preference. In this work physical (dry mass content, hardness, bulk density, and colour), sensory (appearance, colour, odour, taste, texture) and nutritional (antioxidant activity and total phenolics) properties of dried apple snack were investigated as a function of pre-drying, microwave energy input, and batch weight. For evaluation of data, central composite experimental design was applied. According to the results, the physical properties of products produced by microwave vacuum drying combined with hot-air pre-drying (CMVD) mainly depend on the specific energy input. Higher specific energy input results higher dry mass content, which is associated with harder consistency, lower bulk density, and positive consumer perception as well. Bulk density had an optimum point of batch weight at 336 g. Higher value of pre-dried dry mass content resulted lighter colour but less antioxidant activity and less total phenolics, therefore shorter hot-air drying and prolonged microwave vacuum drying is recommended

The Extreme Energy Events HECR array: status and perspectives

The Extreme Energy Events Project is a synchronous sparse array of 52 tracking detectors for studying High Energy Cosmic Rays (HECR) and Cosmic Rays-related phenomena. The observatory is also meant to address Long Distance Correlation (LDC) phenomena: the network is deployed over a broad area covering 10 degrees in latitude and 11 in longitude. An overview of a set of preliminary results is given, extending from the study of local muon flux dependance on solar activity to the investigation of the upward-going component of muon flux traversing the EEE stations; from the search for anisotropies at the sub-TeV scale to the hints for observations of km-scale Extensive Air Shower (EAS).Comment: XXV ECRS 2016 Proceedings - eConf C16-09-04.

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived models and clinical samples from glioblastoma patients treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) demonstrate that tumor cells reversibly up-regulate or suppress mutant EGFR expression, conferring distinct cellular phenotypes to reach an optimal equilibrium for growth. Resistance to EGFR TKIs is shown to occur by elimination of mutant EGFR from extrachromosomal DNA. After drug withdrawal, reemergence of clonal EGFR mutations on extrachromosomal DNA follows. These results indicate a highly specific, dynamic, and adaptive route by which cancers can evade therapies that target oncogenes maintained on extrachromosomal DNA

Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma

At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain tumor stem cells may represent an essential cellular target for glioma therapy as they are postulated to be the tumorigenic cells responsible for recurrence. Targeting oncogenic pathways that are essential to the survival and growth of brain tumor stem cells represents a promising area for developing therapeutics. However, due to the multiple oncogenic pathways involved in glioma, it is necessary to determine which pathways are the essential targets for therapy. Furthermore, research still needs to comprehend the morphogenic processes of cell populations involved in tumor formation. Here, we review research and discuss perspectives on models of glioma in order to delineate the current issues in defining brain tumor stem cells as therapeutic targets in models of glioma

Stem Cells in Drug Screening for Neurodegenerative Disease

Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us access to unlimited numbers of multi-potent or pluripotent cells for screening for new drugs for neurodegenerative diseases. Neural stem cells (NSCs) are a good model with which to screen effective drugs that increase neurogenesis. Recent technologies for human embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) can provide human cells that harbour specific neurodegenerative disease. This article discusses the use of NSCs, ESCs and iPSCs for neurodegenerative drug screening and toxicity evaluation. In addition, we introduce drugs or natural products that are recently identified to affect the stem cell fate to generate neurons or glia

The Character and Artistry of Halsey

Through investigation of her artistic endeavor and personal attitude to the industry, this thesis is to investigate the character of Halsey, a diverse artistic persona created by Ashley Nicolette Frangipane, a 21-year-old singer and musician.The study will attempt to give a detailed insight into the circumstances surrounding a young, biracial, bipolar and bisexual woman, who's artistry is considered deviant and questionable by measures of mainstream conventions.BSc/BAAnglisztikaB