Osteoporose na pós-menopausa e a utilização de bisfosfonatos como opção terapêutica

Uma doença como característica de fragilidade óssea como a Osteoporose que afeta mais de 200 milhões de pessoas ao redor de todo o mundo, tem como principal característica ocorrência de fraturas de baixo impacto. Os pacientes que sobrevivem uma fratura de quadril tornam-se incapazes de manter uma vida independente, onde grande maioria necessita de um ambiente adequado. Num contexto geral esta doença não se apresenta com características clínicas especificas até o momento de uma primeira fratura. É uma patologia que acontece de forma crescente em termos de saúde em ambos os sexos, podendo ser dividida entre primária e secundária. A DMO tem seu pico atingido na idade adulta, mantendo-se constante em ambos os sexos até a idade de aproximadamente 40 anos, onde inicia sua redução espontânea após esta idade. Epidemiologicamente as fraturas vertebrais não são comparadas as fraturas de anca, por existir uma lacuna nos critérios de definição destas fraturas vertebrais. Um nutriente de bastante importância para regulação do tecido ósseo é o cálcio, onde sua ingesta é de extrema importância no tratamento de prevenção de osteoporose, assim como para a saúde óssea em qualquer idade, mesmo que suas necessidades diárias variem de idade para idade. Os bisfosfonatos são compostos sintéticos e possuem alta afinidade com cristais de cálcio no esqueleto, este confere maior resistência em sua degradação biológica. Os bisfosfonatos bloqueiam a quebra de síntese do farnesilpirofosfato e impede a isoprenilasão da guanosina trifosfato, que garante a integridade do citoesqueleto, sua absorção é limitada, tratando-se de uma absorção paracelular

Informative content of food packaging: an exploratory international comparative study, from the point of view of Brazilian and American production and consumption agents. São Paulo, 2000

O objetivo do presente estudo compreende a análise das estratégias adotadas pelo consumidor por ocasião da seleção, aquisição e uso dos alimentos, no que tange o conteúdo informativo das embalagens de alimentos. Realizou-se um Estudo Exploratório Internacional Comparado (EEIC), segundo a ótica brasileira e norte-americana dos agentes de produção e consumo. O enfoque da pesquisa voltou-se para os aspectos relacionados à identificação da estrutura ordenada de preferência pelos atributos de uma dada categoria de produto alimentício. A abordagem sistêmica contribuiu para ressaltar que a comunicação dos atributos do produto é feita em função do seu público consumidor. Concluí-se que a adoção de medidas que levem em consideração a relevância dos atributos do produto, bem como as peculiaridades de cada cultura irão subsidiar a tomada de decisão dos profissionais envolvidos no processo de desenvolvimento da embalagem, no sentido de buscar o aprimoramento do conjunto de informações voltado para a promoção e venda dos gêneros alimentícios, segundo as exigências do mercado de consumo. A busca constante pela atualização, modernização e padronização das informações contidas nas embalagens de alimentos evitará que o consumidor desenvolva conceitos errôneos e/ou empregue inadequadamente um determinado produto alimentício em sua dieta alimentar diária.This study examined the effect of the information content on the consumer\'s strategies when selecting, acquiring and using foods. Based on the bibliography about these issues, an exploratory international comparative study has been carried out, from the point of view of Brazilian and American production and consumption agents. The study attempted to obtain new information on the preference structure of consumer through a list of attributes of a food item which is commercialized in both countries studied. The proposed systemic approach has demonstrated to be helpful for recognition that the communication of the attributes of a food item is done based on the behavior of the consumer in relation to the use that he or she makes of the information contained on food packaging. Briefly stated the adoption of measures which take in consideration the ranking of the attributes of a food item, as well the peculiar characteristics of each culture might contribute to facilitate the made decision of professionals charged in the process for package development to improve the presentation of a set of information, for the publicity and sales of foodstuffs according to the demands of the market. The search for a set of information up-to-date, modem and standardized might help the consumers to use property a foodstuff in their daily feed diet

Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

Glycolipid metabolic disorders (GLMDs) are various metabolic disorders resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake and a lack of physical activity may contribute to oxidative stress (OxS) and systemic inflammation. This study aimed to review the connection between GLMD, OxS, metainflammation, and the onset of CRVD. GLMD is due to various metabolic disorders causing dysfunction in the synthesis, breakdown, and absorption of glucose and lipids in the body, resulting in excessive ectopic accumulation of these molecules. This is mainly due to neuroendocrine dysregulation, insulin resistance, OxS, and metainflammation. In GLMD, many inflammatory markers and defense cells play a vital role in related tissues and organs, such as blood vessels, pancreatic islets, the liver, muscle, the kidneys, and adipocytes, promoting inflammatory lesions that affect various interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, and sphingosine-1-phosphate (S1P) play a crucial role in GLMD since they are related to glucolipid metabolism. The consequences of this is system organ damage and increased morbidity and mortality

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved