90 research outputs found
Patología urinaria de urgencias en gatos: aspectos clínicos y epidemiológicos
La enfermedad renal en gatos es una patología común en la clínica de animales de compañía y tiene una gran importancia dentro del ámbito de las urgencias. Este trabajo pretende dar un enfoque claro y práctico sobre las patologías renales más frecuentes que pueden encontrarse bajo situaciones de emergencia y que muchas veces requieren de una actuación rápida y posterior diagnóstico. Para ello nos basaremos en un estudio realizado a lo largo de seis meses en una clínica veterinaria de urgencias situada en el centro de Zaragoza (Emvet Zaragoza, España). Se hablará por un lado de las enfermedades renales obstructivas y por otro de las no obstructivas, y a su vez se explicarán los distintos orígenes posibles: prerrenal, renal y postrrenal. En la práctica, la diferenciación entre pacientes renales crónicos y agudos es en ocasiones difícil, ya que pacientes crónicos no diagnosticados pueden agudizar su enfermedad y, al contrario, pacientes renales agudos pueden llegar a desarrollar una enfermedad renal crónica posterior. Dado el problema que surge por tanto, es importante realizar las pruebas oportunas que nos ayuden a conocer mejor la lesión de nuestro paciente. Uno de los parámetros estrella del diagnóstico de enfermedad renal hasta el momento es la creatinina, cuya medida en sangre correlaciona la Tasa de Filtración Glomerular (TFG) del riñón, sin embargo tiene sus inconvenientes y en ocasiones puede entorpecer nuestro diagnóstico. Un nuevo biomarcador, la dimetil arginina simétrica (SDMA) comercializada desde julio de 2015, ha sido probado como un parámetro predictivo capaz de detectar fallos renales mucho antes y con mayor especificidad que la creatinina. El presente estudio tiene por objeto conocer lo que ocurre con los valores de SDMA en pacientes felinos renales de urgencia cuyas lesiones estén a varios niveles (prerrenal, renal y postrrenal), en comparación a los valores de creatinina bajo las mismas condiciones
Variations in fruit ploidy level and cell size between small- and large-fruited olive cultivars during fruit ontogeny
Olive (Olea europaea L.) is one of the major oil fruit tree crops worldwide. However, the mechanisms underlying olive fruit growth remain poorly understood. Here, we examine questions regarding the interaction of endoreduplication, cell division, and cell expansion with olive fruit growth in relation to the final fruit size by measuring fruit diameter, pericarp thickness, cell area, and ploidy level during fruit ontogeny in three olive cultivars with different fruit sizes. The results demonstrate that differences in the fruit size are related to the maximum growth rate between olive cultivars during early fruit growth, about 50 days post-anthesis (DPA). Differences in fruit weight between olive cultivars were found from 35 DPA, while the distinctive fruit shape became detectable from 21 DPA, even though the increase in pericarp thickness became detectable from 7 DPA in the three cultivars. During early fruit growth, intense mitotic activity appeared during the first 21 DPA in the fruit, whereas the highest cell expansion rates occurred from 28 to 42 DPA during this phase, suggesting that olive fruit cell number is determined from 28 DPA in the three cultivars. Moreover, olive fruit of the large-fruited cultivars was enlarged due to relatively higher cell division and expansion rates compared with the small-fruited cultivar. The ploidy level of olive fruit pericarp between early and late growth was different, but similar among olive cultivars, revealing that ploidy levels are not associated with cell size, in terms of different 8C levels during olive fruit growth. In the three olive cultivars, the maximum endoreduplication level (8C) occurred just before strong cell expansion during early fruit growth in fruit pericarp, whereas the cell expansion during late fruit growth occurred without preceding endoreduplication. We conclude that the basis for fruit size differences between olive cultivars is determined mainly by different cell division and expansion rates during the early fruit growth phase. These data provide new findings on the contribution of fruit ploidy and cell size to fruit size in olive and ultimately on the control of olive fruit development.Agencia Estatal de Investigación | Ref. RTI2018-097244-B-I00Agencia Estatal de Investigación | Ref. PID2022-138573OB-I0
ACTN3 R577X Polymorphism does not Influence Explosive Leg Muscle Power in Elite Volleyball Players
We examined the association of R577X polymorphism (rs1815739) in the α-actinin-3 (ACTN3) gene with “explosive” leg muscle power performance in a group of male and female elite volleyball players (n=66, 31 men, 35 women) and in a group of non-athletic male and female young adults (n=334, 243 men, 91 women). We assessed power performance by means of the vertical squat and counter-movement jump tests. We also determined whether the genotypic frequencies of the ACTN3 R577X genotypes differed between groups. We did not observe any effect of the ACTN3 R577X polymorphism on study phenotypes in both groups, regardless of gender (all P>0.05). Genotype frequencies were similar between volleyball and control groups (P=0.095). Moreover, we did not find an association between the ACTN3 R577X polymorphism and the likelihood of being an elite volleyball player using the dominant (RR vs RX+XX) and the recessive model (RR+RX vs XX). In summary, these findings suggest that the ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players
Therapeutic Exercise and Pain Neurophysiology Education in Female Patients with Fibromyalgia Syndrome: A Feasibility Study
Background: We compared the effects of therapeutic exercise (TE) combined with pain neurophysiology education (PNE) to those of TE in isolation on pain intensity, general fibromyalgia impact, mechanical pain sensitivity, pain catastrophizing, psychological distress and quality of life in women with fibromyalgia syndrome (FMS).
Methods: A feasibility study with a 3 month follow-up was designed. Thirty-two patients with FMS were randomly assigned to PNE + TE group (n = 16) or to TE group (n = 16). Both groups received 30 sessions of TE (3 per week), and the PNE + TE group received eight face-to-face educational sessions. The measuring instruments used were the visual analogue scale, a standard pressure algometer, the Revised Fibromyalgia Impact Questionnaire, the Pain Catastrophizing Scale, the Hospital Anxiety and Depression Scale and the Health Assessment Questionnaire.
Results: The PNE + TE group showed a statistically significant decrease on pain intensity compared to TE group at short term (p = 0.015). No between-groups differences were found for mechanical pain sensitivity, general fibromyalgia impact, pain catastrophizing, psychological distress or quality of life (p > 0.05).
Conclusions: The combination of PNE and TE was more effective than TE for reducing pain intensity in the short-term. No differences were found for psychological distress, pain catastrophizing and quality of life after the intervention or at 3 months of follow-up
Coupled dark matter-dark energy in light of near Universe observations
Cosmological analysis based on currently available observations are unable to
rule out a sizeable coupling among the dark energy and dark matter fluids. We
explore a variety of coupled dark matter-dark energy models, which satisfy
cosmic microwave background constraints, in light of low redshift and near
universe observations. We illustrate the phenomenology of different classes of
dark coupling models, paying particular attention in distinguishing between
effects that appear only on the expansion history and those that appear in the
growth of structure. We find that while a broad class of dark coupling models
are effectively models where general relativity (GR) is modified --and thus can
be probed by a combination of tests for the expansion history and the growth of
structure--, there is a class of dark coupling models where gravity is still
GR, but the growth of perturbations is, in principle modified. While this
effect is small in the specific models we have considered, one should bear in
mind that an inconsistency between reconstructed expansion history and growth
may not uniquely indicate deviations from GR. Our low redshift constraints
arise from cosmic velocities, redshift space distortions and dark matter
abundance in galaxy voids. We find that current data constrain the
dimensionless coupling to be |xi|<0.2, but prospects from forthcoming data are
for a significant improvement. Future, precise measurements of the Hubble
constant, combined with high-precision constraints on the growth of structure,
could provide the key to rule out dark coupling models which survive other
tests. We shall exploit as well weak equivalence principle violation arguments,
which have the potential to highly disfavour a broad family of coupled models.Comment: 34 pages, 6 figures; changes to match published versio
The central slope of dark matter cores in dwarf galaxies: Simulations vs. THINGS
We make a direct comparison of the derived dark matter (DM) distributions
between hydrodynamical simulations of dwarf galaxies assuming a LCDM cosmology
and the observed dwarf galaxies sample from the THINGS survey in terms of (1)
the rotation curve shape and (2) the logarithmic inner density slope alpha of
mass density profiles. The simulations, which include the effect of baryonic
feedback processes, such as gas cooling, star formation, cosmic UV background
heating and most importantly physically motivated gas outflows driven by
supernovae (SNe), form bulgeless galaxies with DM cores. We show that the
stellar and baryonic mass is similar to that inferred from photometric and
kinematic methods for galaxies of similar circular velocity. Analyzing the
simulations in exactly the same way as the observational sample allows us to
address directly the so-called "cusp/core" problem in the LCDM model. We show
that the rotation curves of the simulated dwarf galaxies rise less steeply than
CDM rotation curves and are consistent with those of the THINGS dwarf galaxies.
The mean value of the logarithmic inner density slopes alpha of the simulated
galaxies' dark matter density profiles is ~ -0.4 +- 0.1, which shows good
agreement with \alpha = -0.29 +- 0.07 of the THINGS dwarf galaxies. The effect
of non-circular motions is not significant enough to affect the results. This
confirms that the baryonic feedback processes included in the simulations are
efficiently able to make the initial cusps with \alpha ~ -1.0 to -1.5 predicted
by dark-matter-only simulations shallower, and induce DM halos with a central
mass distribution similar to that observed in nearby dwarf galaxies.Comment: 13 pages, 7 figures; Accepted for publication in AJ; minor
correction
Human renal adipose tissue from normal and tumor kidney: ITS influence on renal cell carcinoma
Tumor cells can interact with neighboring adipose tissue. We evaluated components present in human adipose explants from normal (hRAN) and kidney cancer (hRAT) tissue, and we evaluated the effects of conditioned media (CMs) from hRAN and hRAT on proliferation, adhesion and migration of tumor and non- tumor human renal epithelial cell lines. In addition, we evaluated the expression of AdipoR1, ObR, CD44, vimentin, pERK and pPI3K on cell lines incubated with CMs. hRAN were obtained from healthy operated donors, and hRAT from patients who underwent a nephrectomy. hRAT showed increased levels of versican, leptin and ObR; and decreased levels of perilipin, adiponectin and AdipoR1, compared to hRAN. Cell lines showed a significant decrease in cell adhesion and increase in cell migration after incubation with hRAT-CMs vs. hRAN- or control-CMs. Surprisingly, HK-2, 786- O and ACHN cells showed a significant decrease in cell migration after incubation with hRAN-CMs vs. control-CMs. No difference in proliferation of cell lines was found after 24 or 48 h of treatment with CMs. AdipoR1 in ACHN and Caki-1 cells decreased significantly after incubation with hRAT-CMs vs. hRAN-CMs and control-CMs. ObR and CD44 increased in tumor line cells, and vimentin increased in non-tumor cells, after incubation with hRAT-CMs vs. hRAN-CMs and control-CMs. We observed an increase in the expression of pERK and pPI3K in HK-2, 786-O and ACHN, incubated with hRAT- CMs. In conclusion, results showed that adipose microenvironment can regulate thebehavior of tumor and non tumor human renal epithelial cells.Fil: Bruna, Flavia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Desarrollo; Chile. Universidad Nacional de Cuyo. Facultad de Odontologia; ArgentinaFil: Romeo, Leonardo Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Hospital Español de Mendoza; ArgentinaFil: Campo Verde Arbocco, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Contador, David. Universidad del Desarrollo; ChileFil: Gomez, Silvina Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Santiano, Flavia Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Sasso, Corina Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Zyla, Leila Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Caron, Ruben Walter. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Pistone Creydt, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentin
Collisionally inhomogeneous Bose-Einstein condensates in double-well potentials
In this work, we consider quasi-one-dimensional Bose-Einstein condensates
(BECs), with spatially varying collisional interactions, trapped in double well
potentials. In particular, we study a setup in which such a 'collisionally
inhomogeneous' BEC has the same (attractive-attractive or repulsive-repulsive)
or different (attractive-repulsive) type of interparticle interactions. Our
analysis is based on the continuation of the symmetric ground state and
anti-symmetric first excited state of the noninteracting (linear) limit into
their nonlinear counterparts. The collisional inhomogeneity produces a
saddle-node bifurcation scenario between two additional solution branches; as
the inhomogeneity becomes stronger, the turning point of the saddle-node tends
to infinity and eventually only the two original branches remain present, which
is completely different from the standard double-well phenomenology. Finally,
one of these branches changes its monotonicity as a function of the chemical
potential, a feature especially prominent, when the sign of the nonlinearity
changes between the two wells. Our theoretical predictions, are in excellent
agreement with the numerical results.Comment: 14 pages, 12 figures, Physica D, in pres
The Atacama Cosmology Telescope (ACT): Beam Profiles and First SZ Cluster Maps
The Atacama Cosmology Telescope (ACT) is currently observing the cosmic
microwave background with arcminute resolution at 148 GHz, 218 GHz, and 277
GHz. In this paper, we present ACT's first results. Data have been analyzed
using a maximum-likelihood map-making method which uses B-splines to model and
remove the atmospheric signal. It has been used to make high-precision beam
maps from which we determine the experiment's window functions. This beam
information directly impacts all subsequent analyses of the data. We also used
the method to map a sample of galaxy clusters via the Sunyaev-Zel'dovich (SZ)
effect, and show five clusters previously detected with X-ray or SZ
observations. We provide integrated Compton-y measurements for each cluster. Of
particular interest is our detection of the z = 0.44 component of A3128 and our
current non-detection of the low-redshift part, providing strong evidence that
the further cluster is more massive as suggested by X-ray measurements. This is
a compelling example of the redshift-independent mass selection of the SZ
effect.Comment: 16 pages, 10 figures. Accepted for publication in ApJS. See Marriage
et al. (arXiv:1010.1065) and Menanteau et al. (arXiv:1006.5126) for
additional cluster result
The Atacama Cosmology Telescope: Physical Properties and Purity of a Galaxy Cluster Sample Selected via the Sunyaev-Zel'dovich Effect
We present optical and X-ray properties for the first confirmed galaxy
cluster sample selected by the Sunyaev-Zel'dovich Effect from 148 GHz maps over
455 square degrees of sky made with the Atacama Cosmology Telescope. These
maps, coupled with multi-band imaging on 4-meter-class optical telescopes, have
yielded a sample of 23 galaxy clusters with redshifts between 0.118 and 1.066.
Of these 23 clusters, 10 are newly discovered. The selection of this sample is
approximately mass limited and essentially independent of redshift. We provide
optical positions, images, redshifts and X-ray fluxes and luminosities for the
full sample, and X-ray temperatures of an important subset. The mass limit of
the full sample is around 8e14 Msun, with a number distribution that peaks
around a redshift of 0.4. For the 10 highest significance SZE-selected cluster
candidates, all of which are optically confirmed, the mass threshold is 1e15
Msun and the redshift range is 0.167 to 1.066. Archival observations from
Chandra, XMM-Newton, and ROSAT provide X-ray luminosities and temperatures that
are broadly consistent with this mass threshold. Our optical follow-up
procedure also allowed us to assess the purity of the ACT cluster sample.
Eighty (one hundred) percent of the 148 GHz candidates with signal-to-noise
ratios greater than 5.1 (5.7) are confirmed as massive clusters. The reported
sample represents one of the largest SZE-selected sample of massive clusters
over all redshifts within a cosmologically-significant survey volume, which
will enable cosmological studies as well as future studies on the evolution,
morphology, and stellar populations in the most massive clusters in the
Universe.Comment: 20 pages, 15 figures, 6 tables. Accepted for publication in ApJ.
Higher resolution figures available at:
http://peumo.rutgers.edu/~felipe/e-prints
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