A study of Dickens as moralist.

In this thesis I want to discuss five of Dickens's novels, written more or less in the middle of his writing career. These novels cover the years 1846 to 1857; they are Dombey and Son, David Copperfield, Bleak House, figgg Eimgg and Little Dorrit. Dickens was forty-five years old when he finished Little Dorrit, so that this period spans the middle years of his personal life as well. While I will be tracing what I consider to be a general line of development through the five consecutive novels, that will not be the real preoccupation of my thesis. I will primarily be looking at two closely linked general questions, which, despite the outpouring of Dickens studies in recent years, have not, I think, been overworked, or even over—explored. The first question, briefly, is this: is there discernible, in all the variety of Dickens's work, a philosophy of life, or a Dickensian point of view? Is Dickens's view of the moral universe a specific and defineable one? In particular, are there any dominant ideas about the nature of fate and the ability of man to control his own existence

Referral Patterns Between Allopathic Physicians and Complementary and Alternative Medicine Practitioners

Introduction and Objectives: The provision of basic healthcare in the United States may be viewed considering two different, and sometimes combined, therapeutic approaches: •Allopathic/osteopathic medicine •Complementary and alternative medicine (CAM) Our study is interested in the intersection of allopathic medicine and CAM. Evidence suggests that Americans are seeking CAM at a similar or even a higher rate than allopathic medicine, yet there seems to be a division between practitioners of each discipline. Isthis division created by a lack of coordination, such as an inadequately established referral system, or by a general lack of knowledge, or by the attitudes of the practitioners? In our study our objectives were: ? To assess the referral patterns between allopathic and CAM practitioners in Chittenden County. ? To examine the various factors that may influence these referral patterns using confidential surveys.https://scholarworks.uvm.edu/comphp_gallery/1017/thumbnail.jp

Transcatheter placement of a low-profile biodegradable pulmonary valve made of small intestinal submucosa: A long-term study in a swine model

ObjectiveWe sought to investigate a placement of a percutaneous low-profile prosthetic valve constructed of small intestinal submucosa in the pulmonary position in a swine model.MethodsTwelve female farm pigs were stented at the native pulmonary valve to induce pulmonary insufficiency. Once right ventricular dilation occurred, the small intestinal submucosa valve was implanted. The pigs were followed up with transthoracic echocardiographic Doppler scanning. One animal died of heart failure before valve replacement. Animals were euthanized at 1 day, 1 month, 3 months, 6 months, and 12 months after valve implantation.ResultsThe small intestinal submucosa pulmonary valve showed effective reversal of pulmonary regurgitation. There were no misplacements during deployment. There were no embolizations. One-year echocardiographic follow-up showed minimal regurgitation and no stenosis for a valve/vessel ratio of 0.78 or greater. Histologic examination demonstrated intensive remodeling of the small intestinal submucosal valve. Within 1 month, the surface was covered by endothelium, and fibroblasts invaded the interior. Over the following months, the small intestinal submucosal valve remodeled without apparent graft rejection.ConclusionThe small intestinal submucosa valve has the potential for graft longevity without the need for anticoagulation or immunosuppression. Histologic remodeling of the valve tissue provides a replacement capable of resembling a native valve that can be placed percutaneously with low-profile delivery systems

Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk

Angelika Varga has been supported by a European Union Marie Curie Intra-European Fellowship (254661), a Hungarian Social Renewal Operation Program (TÁMOP 4.1.2.E-13/1/KONV-2013-0010) and the Hungarian Brain Research program (KTIA_NAP_13-2-2014-0005) of the Hungarian Government. Agnes Jenes has been supported by a BJA/RCoA Project Grant. This work has also been supported, in part, by the BIOSS-2 Grant, Project A6.

Effects of trichothecene production by Trichoderma arundinaceum isolates from bean-field soils on the defense response, growth and development of bean plants (Phaseolus vulgaris)

[EN] The trichothecene toxin-producing fungus Trichoderma arundinaceum has potential as a biological control agent. However, most biocontrol studies have focused only on one strain, IBT 40837. In the current study, three Trichoderma isolates recovered from bean-field soils produced the trichothecene harzianum A (HA) and trichodermol, the latter being an intermediate in the HA biosynthesis. Based on phylogenetic analysis, the three isolates were assigned to the species T. arundinaceum. Their genome sequences had a high degree of similarity to the reference IBT 40837 strain, in terms of total genome size, number of predicted genes, and diversity of putative secondary metabolite biosynthetic gene clusters. HA production by these bean-field isolates conferred significant in vitro antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum, which are some of the most important bean pathogens. Furthermore, the bean-field isolates stimulated germination of bean seeds and subsequent growth of above ground parts of the bean plant. Transcriptomic analysis of bean plants inoculated with these T. arundinaceum bean-field soil isolates indicated that HA production significantly affected expression of plant defense-related genes; this effect was particularly significant in the expression of chitinase-encoding genes. Together, these results indicate that Trichoderma species producing non-phytotoxic trichothecenes can induce defenses in plants without negatively affecting germination and developmentSIThis work is a part of the Spanish I+D+i Grants RTI2018-099600-B-I00 and PID2021-123874OB-I00, financed by the MCIN/ AEI/10.13039/501100011033. GC-H was awarded with a Grant from the Ministry of Education, Culture, and Sport (Spain) (Grant number FPU15/04681). NM-R was awarded with a Grant from the Junta de Castilla y León (Spain) (ORDEN EDU/875/2021, July 13th, 2021

Transepithelial migration of neutrophils into the lung requires TREM-1

Acute respiratory infections are responsible for more than 4 million deaths each year. Neutrophils play an essential role in the innate immune response to lung infection. These cells have an armamentarium of pattern recognition molecules and antimicrobial agents that identify and eliminate pathogens. In the setting of infection, neutrophil triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammatory signaling. Here we demonstrate for the first time that TREM-1 also plays an important role in transepithelial migration of neutrophils into the airspace. We developed a TREM-1/3–deficient mouse model of pneumonia and found that absence of TREM-1/3 markedly increased mortality following Pseudomonas aeruginosa challenge. Unexpectedly, TREM-1/3 deficiency resulted in increased local and systemic cytokine production. TREM-1/3–deficient neutrophils demonstrated intact bacterial killing, phagocytosis, and chemotaxis; however, histologic examination of TREM-1/3–deficient lungs revealed decreased neutrophil infiltration of the airways. TREM-1/3–deficient neutrophils effectively migrated across primary endothelial cell monolayers but failed to migrate across primary airway epithelia grown at the air-liquid interface. These data define a new function for TREM-1 in neutrophil migration across airway epithelial cells and suggest that it amplifies inflammation through targeted neutrophil migration into the lung

Kutatási füzetek 19.

Szerkesztők: Bene Krisztián; Dávid Ferenc; Deák Máté; Gőzsy Zoltán; Vitári Zsolt | További szerzők: Árvai Tamás Kristóf; Berta János; Csibi Norbert; Farkas Péter; Gazdag László; Glanz, Susan; Hantos-Varga Márta; Madácsy József; Szarka Evelin; Szőke Noémi; Zárol Evelin | Cím: Kutatási füzetek 19. | Megjelenési adatok: Pécsi Tudományegyetem, Pécs, 2013. | ISSN: 1416-0986 | Megjegyzés: A Kutatási Füzetek a Pécsi Tudományegyetem Interdiszciplináris Doktori Iskolájának kiadványsorozata. Az MTA–PTE Magyarország. A kötet a Tudományos képzés műhelyeinek támogatása a Pécsi Tudományegyetemen (TÁMOP 4.2.2/B-10/1-2010-0029) projekt támogatásával készült.(1) Árvai Tamás Kristóf: Asszíria mentális háborúja 13-34 | (2) Berta János: Miért adhat a hetvenes évek magyar dokumentumfilmje a (társadalom)történetírás számára? 35-55 | (3) Csibi Norbert: Jubileumi seregszemle - Az 1910. évi magyarországi országos katolikus nagygyűlés és közművelődési szakosztálya 57-77 | (4) Farkas Péter: Bíráskodás a veszprémi püspökség egyházi nemesei felett a 14. században 79-97 | (5) Gazdag László: Herczeg Ferenc és a magyar társadalmi kérdések 99-121 | (6) Glanz, Susan: The Battles of Hunyadi János in America 123-149 | (7) Hantos-Varga Márta: A katolikus politikai cselekvés teoretikus megközelítése a két világháború közötti Magyarországon 151-170 | (8) Madácsy József: Gregory Bateson és az Anonim Alkoholisták II. 171-191 | (9) Szarka Evelin: Az istenek szigete a 21. században – Spirituális építészeti elvek és a városfejlesztés nehézségei Balin 193-214 | (10) Szőke Noémi: A munkásosztálybeli szingli 215-236 | (11) Zárol Evelin: A Dél-Dunántúli Régió időseket gondozó intézményrendszere 237-26

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

The E3 ubiquitin ligase component FBXW7 modulates homeostasis and inhibits tumorigenesis in the murine intestine

How art constitutes the human : aesthetics, empathy, and the interesting in autofiction

This chapter examines ‘graphic autofiction’ in Lynda Barry’s One! Hundred! Demons! (2002) and What It Is (2009) and Phoebe Gloeckner’s A Child’s Life and Other Stories (2000) and The Diary of A Teenage Girl: An Account in Words and Pictures (2002), demonstrating how it allows feminist performances that visualize cartoonists’ authentic experiences of sexual and other forms of trauma. The chapter makes a valuable contribution to current debates on autofiction by moving beyond its literary expressions and investigating how the hybrid medium of comics accommodates the genre and how that, in its turn, complicates the representation of trauma. It also proposes that ‘graphic autofiction’ allows the formation of feminist counter-narratives to the silencing of female abuse victims and the latter’s representation beyond victimhood

Validation of the Body Concealment Scale for Scleroderma (BCSS): Replication in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort

© 2016 Elsevier Ltd Body concealment is an important component of appearance distress for individuals with disfiguring conditions, including scleroderma. The objective was to replicate the validation study of the Body Concealment Scale for Scleroderma (BCSS) among 897 scleroderma patients. The factor structure of the BCSS was evaluated using confirmatory factor analysis and the Multiple-Indicator Multiple-Cause model examined differential item functioning of SWAP items for sex and age. Internal consistency reliability was assessed via Cronbach's alpha. Construct validity was assessed by comparing the BCSS with a measure of body image distress and measures of mental health and pain intensity. Results replicated the original validation study, where a bifactor model provided the best fit. The BCSS demonstrated strong internal consistency reliability and construct validity. Findings further support the BCSS as a valid measure of body concealment in scleroderma and provide new evidence that scores can be compared and combined across sexes and ages