3,393 research outputs found
The macaroni sign
A 41-year-old woman was referred to radiology department for the evaluation of sudden paresis in the left side. Brain magnetic resonance imaging (MRI) showed multiple bilateral ischemic regions in the watershed areas. Also, the brain magnetic resonance angiography (MRA) showed bilateral internal carotid artery (ICA) occlusions at the level of the cervical ICA region. Both vertebral arteries were found to be enlarged (arrow) and the retrograde filling of the anterior circulation was observed (Fig. A). For the investigation and the differentiation of the bilateral carotid lesions, the color Doppler ultrasonography was obtained. This study showed homogenous, hypoechoic, circumferential wall thickening of both distal common carotid artery arteries (CCA). The thickening of the arteries wall were like âMacaroniâ. The wall thickness was 0.17 cm (Fig. B). The tapering of both CCA and total oclusion of both ICA were seen. The carotid MRA revealed collateral circulation from the subclavian arteries to the ECA and 50% stenosis of the left CCA (arrow) and 70% stenosis of the right CCA at its origin. Vertebral arteries were also prominant and there were 50% narrowing in the mid portion of the left subclavian artery (Fig. C). The radiological diagnosis of the Takayasuâs arteritis (TA) was made and the patient was referred to the rheumatology clinic for further diagnosis and work-up
Comparison of patients receiving salicylate before coronary artery surgery with patients not receiving in terms of postoperative mortality rates
New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases.
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production. (J Histochem Cytochem XX.XXX-XXX, XXXX)
Bigger, Better, Faster, More at the LHC
Multijet plus missing energy searches provide universal coverage for theories
that have new colored particles that decay into a dark matter candidate and
jets. These signals appear at the LHC further out on the missing energy tail
than two-to-two scattering indicates. The simplicity of the searches at the LHC
contrasts sharply with the Tevatron where more elaborate searches are necessary
to separate signal from background. The searches presented in this article
effectively distinguish signal from background for any theory where the LSP is
a daughter or granddaughter of the pair-produced colored parent particle
without ever having to consider missing energies less than 400 GeV.Comment: 26 pages, 8 Figures. Minor textual changes, typos fixed and
references adde
Where the Sidewalk Ends: Jets and Missing Energy Search Strategies for the 7 TeV LHC
This work explores the potential reach of the 7 TeV LHC to new colored states
in the context of simplified models and addresses the issue of which search
regions are necessary to cover an extensive set of event topologies and
kinematic regimes. This article demonstrates that if searches are designed to
focus on specific regions of phase space, then new physics may be missed if it
lies in unexpected corners. Simple multiregion search strategies can be
designed to cover all of kinematic possibilities. A set of benchmark models are
created that cover the qualitatively different signatures and a benchmark
multiregion search strategy is presented that covers these models.Comment: 30 pages, 8 Figures, 3 Tables. Version accepted at JHEP. Minor
changes. Added figur
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
Compressed representation of a partially defined integer function over multiple arguments
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
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