Die Rezidive der aggressiven Fibromatosen:Prognostische klinische und immunhistochemische Parameter für ihre Entstehung und Konsequenzen für die Therapie

Aggressive Fibromatosen sind seltene fibroblastisch/myofibroblastisch differenzierte Weichgewebsneoplasien mit lokal aggressiven und infiltrativen Wachstumsmustern. Trotz weiter oder marginaler Resektionen rezidivieren sie häufig mehrfach. Ziel dieser Studie war die Analyse klinischer und histopathologischer Parameter mit möglichem prognostischen Einfluss auf die Entstehung von Lokalrezidiven. 54 Desmoide wurden retrospektiv unter Berücksichtigung klinischer Parameter (Geschlechtsverteilung, Patientenalter, Lokalisation, Tumorgröße, Resektionsstatus, adjuvante Radiatio) analysiert. Eine immunhistochemische Untersuchung wurde auf betta-Catenin, p53, SMA, Desmin, Ki-7, c-erbB2, EGFR, c-kit, CD34 und S-100 mit 24 Patienten durchgeführt. Ein Patientenalter 50 Jahren und das Nicht-Erhalten einer adjuvanten Radiatio waren signifikant mit einer erhöhten Lokalrezidivrate assoziiert; ebenso eine erhöhte nukleare betta-Catenin Expression und/oder p53 Expression

Assessment of varicella vaccine effectiveness in Germany: a time-series approach

A multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83·2% (95% CI 80·2-85·7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the US

A General Framework for Ordering Fuzzy Sets

Abstract. Orderings and rankings of fuzzy sets have turned out to play a funda-mental role in various disciplines. Throughout the previous 25 years, a lot a different approaches to this issue have been introduced, ranging from rather simple ones to quite exotic ones. The aim of this paper is to present a new framework for com-paring fuzzy sets with respect to a general class of fuzzy orderings. This approach includes several known techniques based on generalizing the crisp linear ordering of real numbers by means of the extension principle, however, in its general form, it is applicable to any fuzzy subsets of any kind of universe for which a fuzzy ordering is known – no matter whether linear or partial.

Alignment of the CMS tracker with LHC and cosmic ray data

© CERN 2014 for the benefit of the CMS collaboration, published under the terms of the Creative Commons Attribution 3.0 License by IOP Publishing Ltd and Sissa Medialab srl. Any further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation and DOI.The central component of the CMS detector is the largest silicon tracker ever built. The precise alignment of this complex device is a formidable challenge, and only achievable with a significant extension of the technologies routinely used for tracking detectors in the past. This article describes the full-scale alignment procedure as it is used during LHC operations. Among the specific features of the method are the simultaneous determination of up to 200 000 alignment parameters with tracks, the measurement of individual sensor curvature parameters, the control of systematic misalignment effects, and the implementation of the whole procedure in a multi-processor environment for high execution speed. Overall, the achieved statistical accuracy on the module alignment is found to be significantly better than 10μm

Enriched MV-algebras

This paper introduces the structure of enriched MV--algebras and studies on this basis various relations between sigma--complete MV--algebras and T--tribes

Enriched MV-algebras

This paper introduces the structure of enriched MV--algebras and studies on this basis various relations between sigma--complete MV--algebras and T--tribes