Gastric Diverticulum of the Prepyloric Region: A Rare Presentation of Gastric Diverticulum

Gastric diverticula are the least common diverticula of the gastrointestinal tract. The two main categories identified are congenital and acquired ones. Diverticula of the antrum, prepyloric or pyloric, are extremely rare and usually asymptomatic. We report a diverticulum of the prepyloric region in a patient with a background of peptic ulcer disease and antiplatelet treatment who became symptomatic and was treated successfully with proton pump inhibitors

Synthesis, characterization and crystal structure of a novel mononuclear peroxotungsten(VI) complex with an acetone peroxide ligand

A new mononuclear peroxo complex of tungsten of the formula (gu)2[WO(O2)2CO(O)2(CH3)2](CH3)2CO (where gu+ = guanidinium ion, CN3H6+ion) has been synthesized and characterized by infrared, Raman, and 1H NMR spectroscopies. The crystal structure of (gu)2[WO(O2)2CO(O)2(CH3)2](CH3)2CO determined by X-ray diffraction indicates that the side-on peroxo groups and the bidentate acetone peroxide ligand bind the W(VI) centre leading to an hepta coordination mode. The guanidinium ion occurring as a counterion and the hydrogen-bound interactions stabilize the complexes. The stability of the complex in aqueous solution was determined by Raman and NMR spectroscopies. © 2009 Elsevier Ltd. All rights reserved

Two novel compounds of vanadium and molybdenum with carnitine exhibiting potential pharmacological use

The reaction of sodium orthovanadate with carnitine hydrochloride molecule results in the precipitation of decavanadate compound of carnitine whereas the reaction of metallic molybdenum with hydrogen peroxide and carnitine results in the peroxo-molybdenum complex of carnitine. The decavanadate compound as well as the molybdenum complex of carnitine have been characterized by means of elemental analysis, IR, electronic spectra, 1H NMR, 2D-COSY-NMR (=correlation spectroscopy) and thermo-gravimetric analysis (TGA). In addition decavanadate compound of carnitine was fully characterized by X-ray crystallography. The analytical data were in good agreement with the empirical formulae of both, decavanadate compound and molybdenum complex. The two compounds were also evaluated for cell toxicity and their anticancer activity by the MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)-based assay method, using primary cells and tumor cell lines of both human andmurine origins and the results showthat compound 1 shows an increased biological activity in comparison with compound 2. Moreover using confocal microscopy and antibodies against cleaved caspase 3 we further analyzed the cell toxicity and we conclude that the apoptotic pathway is triggered efficiently with tumor specificity by compound 1 and not by compound 2. © 2014, Elsevier Inc. All rights reserved