Resistencia del P. falciparum a drogas en Colombia 1961-1986

Diferentes informes (24, 27, 3, 4, 8) refieren que la resistencia de los Plasmodium a las drogas antima-Iáricas, principalmente del P. falciparum, es uno de los "problemas técnicos" que han contribuido a agravar la situación de la malaria tanto en Colombia como en el mundo, y, por lo tanto, también se le atribuye papel en la dificultad para la erradicación del paludismo (12, 31)

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

[Letter from Sylvia Trujillo to Joseph R. Benites - September 24, 1974

Letter from Sylvia Trujillo, State Deputy Director, to Joseph R. Benites, League of United Latin American Citizens National President, dated September 24, 1974. The letter indicates that has a meeting has been called to discuss the issues with Benites decision to invite Congressman John Rhodes for a testimonial decision

Aprender a aprender, clave del éxito en las organizaciones : estudio de caso sobre Quala S.A.

10 Páginas.En el mundo de hoy la formación nunca termina. Ninguna organización puede garantizar su avance e innovación si no se asegura que las personas que trabajan en ella, tengan el interés y la posibilidad de formarse continuamente y crear conocimiento propio partir de los éxitos o fracasos del día a día. Por esto hoy se considera fundamental que las empresas promuevan en su interior el aprender a aprender como clave para contar con gente que las lleve al éxito. En este artículo se estudiará el caso de Quala S.A, empresa multinacional que con este principio como filosofía de desarrollo se convirtiendo en 25 años en una de las cinco empresas de consumo masivo más grande del país

Informe final del proyecto de innovación docente "Elaboración de material audiovisual para la mejora de la docencia práctica de asignaturas relacionadas con el lenguaje escrito"

El objetivo fundamental de este proyecto de innovación docente ha sido generar nuevos recursos audiovisuales para la mejora de la docencia de asignaturas relacionadas con la lectura y la escritura. Se han conseguido elaborar 5 DVDs compuestos por 18 vídeos sobre actividades relacionadas con la enseñanza, evaluación e intervención del lenguaje escrito y sus dificultades. En las grabaciones han participado niños y niñas de 1º, 2º, 3º y 5º de Educación Primaria que presentaban diferentes niveles de habilidad (con y sin dificultades de aprendizaje), de modo que se preten de ofrecer a los estudiantes una perspectiva general de la diversidad existente en Educación Primaria. Asimismo, se han conseguido grabar actividades tanto grupales (de enseñanza con el grupo de clase) como individuales (de evaluación e intervención con especialistas). Los materiales generados estarán disponibles para el profesorado que los requiera en las bibliotecas de las Facultades de Psicología y de Ciencias de la Educación.Secretariado de Innovación Docent