Dynamic fine-tuning of CAR-T cell therapy

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Multifunctional Magnetic-fluorescent Nanocomposites for Biomedical Applications

Nanotechnology is a fast-growing area, involving the fabrication and use of nano-sized materials and devices. Various nanocomposite materials play a number of important roles in modern science and technology. Magnetic and fluorescent inorganic nanoparticles are of particular importance due to their broad range of potential applications. It is expected that the combination of magnetic and fluorescent properties in one nanocomposite would enable the engineering of unique multifunctional nanoscale devices, which could be manipulated using external magnetic fields. The aim of this review is to present an overview of bimodal “two-in-one” magnetic-fluorescent nanocomposite materials which combine both magnetic and fluorescent properties in one entity, in particular those with potential applications in biotechnology and nanomedicine. There is a great necessity for the development of these multifunctional nanocomposites, but there are some difficulties and challenges to overcome in their fabrication such as quenching of the fluorescent entity by the magnetic core. Fluorescent-magnetic nanocomposites include a variety of materials including silica-based, dye-functionalised magnetic nanoparticles and quantum dots-magnetic nanoparticle composites. The classification and main synthesis strategies, along with approaches for the fabrication of fluorescent-magnetic nanocomposites, are considered. The current and potential biomedical uses, including biological imaging, cell tracking, magnetic bioseparation, nanomedicine and bio- and chemo-sensoring, of magnetic-fluorescent nanocomposites are also discussed

Recent Developments in Peptide-Based Nucleic Acid Delivery

Despite the fact that non-viral nucleic acid delivery systems are generally considered to be less efficient than viral vectors, they have gained much interest in recent years due to their superior safety profile compared to their viral counterpart. Among these synthetic vectors are cationic polymers, branched dendrimers, cationic liposomes and cell-penetrating peptides (CPPs). The latter represent an assortment of fairly unrelated sequences essentially characterised by a high content of basic amino acids and a length of 10–30 residues. CPPs are capable of mediating the cellular uptake of hydrophilic macromolecules like peptides and nucleic acids (e.g. siRNAs, aptamers and antisense-oligonucleotides), which are internalised by cells at a very low rate when applied alone. Up to now, numerous sequences have been reported to show cell-penetrating properties and many of them have been used to successfully transport a variety of different cargos into mammalian cells. In recent years, it has become apparent that endocytosis is a major route of internalisation even though the mechanisms underlying the cellular translocation of CPPs are poorly understood and still subject to controversial discussions. In this review, we will summarise the latest developments in peptide-based cellular delivery of nucleic acid cargos. We will discuss different mechanisms of entry, the intracellular fate of the cargo, correlation studies of uptake versus biological activity of the cargo as well as technical problems and pitfalls

Absorption des solutions aqueuses d'acide chlorhydrique dans l'ultraviolet lointain

Ce travail consiste en une application des méthodes de photométrie photographique à l'étude du spectre d'absoption des solutions aqueuses d'acide chlorhydrique. Les mesures ont été effectuées dans l'intervalle 2816 - 1990 1. Le gaz chlorhydrique, convenablement purifié par solidification (à l'aide d'air liquide) et distillation fractionnée du liquide de fusion, est dissous dans l'eau purifiée avec le plus grand soin par un procédé indiqué. On décrit toutes les précautions observées pour éviter l'altération des solutions. La source lumineuse est un tube à hydrogène de Chalonge et Lambrey; le spectrographe, du modèle de Hilger à optique de quartz Les clichés sont étudiés au microphotomètre enregistreur de Chalonge et Lambert. Résultats. - L'absorption est parfaitement continue, dans toute l'étendue explorée du spectre, pour toute concentration et à toute température. - Les solutions concentrées présentent très nettement un maximum d'absorption pour 8 mol. 5 envion par litre.- Le coefficient d'absorption moléculaire croît constamment lorsque la concentration diminue. Il croît avec la température. Quelques tableaux numériques et divers réseaux de courbes précisent ces résultats. La loi de Beer de s'applique pas aux solutions aqueuses d'acide chlorhydrique. - L'interprétation de ces phénomènes nécessite la considération de particules absorbantes différentes et le rôle de l'eau est important

Urville

Tréhin, an autistic man with exceptional creative talents and an obsession with large cities, conceived and developed Urville, the capital of a large island province, over 20 years. He shares his vision in this beautifully illustrated guide to the city, which he renders convincingly real in nearly 300 drawings of different districts of Urville.Intro -- Urville -- Contents -- Foreword by Uta Frith -- Preface by Gilles Trehin -- Map of Urville in Provence Insulaire -- Introduction -- A Brief Chronology of the History of Urville -- Chapter 1 - Old town and the rade de Carsouce - the historic quarter of Urville -- Chapter 2: The expansion of Urville -- Chapter 3: The Left Bank of the Écrantes -- Chapter 4: Beaux-Sites, Tression and Valmures -- Chapter 5: Bellevallois, Mascotte and Barongeais -- Chapter 6: Sermaille, Catalogne, Tainon, Montgelat and Fensouque -- Chapter 7: Jonquilles, Académie, République and Fontinelles -- Chapter 8: Liberté, Mirecailles, Quatre-Saisons and Pré Saint-Julien -- Chapter 9: Tégartines, Moineaux, Rossignols -- Chapter 10: Trières, Martin-Pêcheur, La Bourache and Butte Saint-Martin -- Chapter 11: East Central -- Chapter 12: North Industrial -- Chapter 13: The Northeast -- Chapter 14: Futurville 2000 and airportsTréhin, an autistic man with exceptional creative talents and an obsession with large cities, conceived and developed Urville, the capital of a large island province, over 20 years. He shares his vision in this beautifully illustrated guide to the city, which he renders convincingly real in nearly 300 drawings of different districts of Urville.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries

Ville et communication : le témoignage de Claude Trehin, fondateur de l'association « Pour une ville » (Franche-Comté). Interview réalisée par Cynthia Ghorra-Gobin

Trehin Claude, Ghorra-Gobin Cynthia. Ville et communication : le témoignage de Claude Trehin, fondateur de l'association « Pour une ville » (Franche-Comté). Interview réalisée par Cynthia Ghorra-Gobin . In: Quaderni, n°6, Hiver 88/89. Télé-ville. pp. 105-108

Time to stop: flower meristem termination.

International audienc