3,399 research outputs found
Condrosarcoma en pie
El condrosarcoma óseo en el pie es una lesión muy rara. Se presenta 1 caso de bajo
grado de malignidad histológico y primario en su origen, que afecta al primer radio, tratado
mediante resección amplia y sin signos de recidiva a los 3 años y medio de evolución.Bone chondrosarcoma very rarely affccts the foot. We report a case of primary
bone chondrosarcoma vvith low grade malignancy involving the first metatarsal bone. Tumor was
treated by wide resection. Three and half years later, there was not signs of recurrence
Resultados del tratamiento quirúrgico del dolor lumbar con instrumentación diapasón
Se presenta un estudio sobre 23 pacientes con patología lumbosacra tratados
quirúrgicamente mediante artrodesis e instrumentación vertebral transpedicular tipo diapasón.
El promedio de seguimiento ha sido de 25 meses (18-38). El dolor lumbar estaba relacionado en
10 casos con estenosis de canal, en 6 con espondilolistesis y en 7 con hernia discal y artrosis secundaria.
Todos fueron instrumentados por vía posterior mediante fijación transpedicular y artrodesados
posterolateralmente con injerto autólogo. Se consiguió una artrodesis sólida en un
96%. No se han presentado complicaciones preoperatorias. Ocho pacientes presentaron complicaciones
en el postoperatorio inmediato. Observamos un desplazamiento de barra y un desanclaje
del tornillo fuera del pedículo. Siguiendo los criterios de valoración de Henderson se ha conseguido
un 96% de excelentes y buenos resultados.A series of 23 patient with lumbosacral pathology, surgically treated by posterior
arthrodesis and vertebral diapason transpedicular fixation was retrospectively review. The average
follow-up period was 25 months (18-38). The diagnosis was spinal stenosis in 10 cases, spondylolisthesis
in 6, and disc herniation with secondary osteoartrhitis in 7 cases. Apart from transpedicular
fixation all cases underwent posterolateral fusion with autogenous bone graft. A solid arthrodesis
was achieved in a 96% of patients. There were no per-operative complication. Eight cases showed
complications in the immediate postoperative period. We observed displacement of a bar and
detachement of a screw out off the pedicle. According to Henderson's assessment criteria we obtained
96% of excellent and good results
Chemical attributes and microbial activity of soil cultivated with cassava under different cover crops.
Conservationist systems of crop management increases the amount of substrate, alters fertility and increases soil biological activity. The objective of this study was to evaluate the influence of soil management systems on the chemical attributes and microbial activity of soil under cassava crop
Central star formation and metallicity in CALIFA interacting galaxies
We use optical integral-field spectroscopic (IFS) data from 103 nearby
galaxies at different stages of the merging event, from close pairs to merger
remnants provided by the CALIFA survey, to study the impact of the interaction
in the specific star formation and oxygen abundance on different galactic
scales. To disentangle the effect of the interaction and merger from internal
processes, we compared our results with a control sample of 80 non-interacting
galaxies. We confirm the moderate enhancement (2-3 times) of specific star
formation for interacting galaxies in central regions as reported by previous
studies; however, the specific star formation is comparable when observed in
extended regions. We find that control and interacting star-forming galaxies
have similar oxygen abundances in their central regions, when normalized to
their stellar masses. Oxygen abundances of these interacting galaxies seem to
decrease compared to the control objects at the large aperture sizes measured
in effective radius. Although the enhancement in central star formation and
lower metallicities for interacting galaxies have been attributed to tidally
induced inflows, our results suggest that other processes such as stellar
feedback can contribute to the metal enrichment in interacting galaxies.Comment: 9 pages, 9 figures. Accepted for publication in Astronomy &
Astrophysic
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity.
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease models, including cancer models. However, translation of senolytic therapies to human disease is hampered by their suboptimal specificity for senescent cells and important toxicities that narrow their therapeutic windows. We have previously shown that the high levels of senescence-associated lysosomal β-galactosidase (SA-β-gal) found within senescent cells can be exploited to specifically release tracers and cytotoxic cargoes from galactose-encapsulated nanoparticles within these cells. Here, we show that galacto-conjugation of the BCL-2 family inhibitor Navitoclax results in a potent senolytic prodrug (Nav-Gal), that can be preferentially activated by SA-β-gal activity in a wide range of cell types. Nav-Gal selectively induces senescent cell apoptosis and has a higher senolytic index than Navitoclax (through reduced activation in nonsenescent cells). Nav-Gal enhances the cytotoxicity of standard senescence-inducing chemotherapy (cisplatin) in human A549 lung cancer cells. Concomitant treatment with cisplatin and Nav-Gal in vivo results in the eradication of senescent lung cancer cells and significantly reduces tumour growth. Importantly, galacto-conjugation reduces Navitoclax-induced platelet apoptosis in human and murine blood samples treated ex vivo, and thrombocytopenia at therapeutically effective concentrations in murine lung cancer models. Taken together, we provide a potentially versatile strategy for generating effective senolytic prodrugs with reduced toxicities
Operations of and Future Plans for the Pierre Auger Observatory
Technical reports on operations and features of the Pierre Auger Observatory,
including ongoing and planned enhancements and the status of the future
northern hemisphere portion of the Observatory. Contributions to the 31st
International Cosmic Ray Conference, Lodz, Poland, July 2009.Comment: Contributions to the 31st ICRC, Lodz, Poland, July 200
Anisotropy and chemical composition of ultra-high energy cosmic rays using arrival directions measured by the Pierre Auger Observatory
The Pierre Auger Collaboration has reported evidence for anisotropy in the
distribution of arrival directions of the cosmic rays with energies
eV. These show a correlation with the distribution
of nearby extragalactic objects, including an apparent excess around the
direction of Centaurus A. If the particles responsible for these excesses at
are heavy nuclei with charge , the proton component of the
sources should lead to excesses in the same regions at energies . We here
report the lack of anisotropies in these directions at energies above
(for illustrative values of ). If the anisotropies
above are due to nuclei with charge , and under reasonable
assumptions about the acceleration process, these observations imply stringent
constraints on the allowed proton fraction at the lower energies
Update on the correlation of the highest energy cosmic rays with nearby extragalactic matter
Data collected by the Pierre Auger Observatory through 31 August 2007 showed
evidence for anisotropy in the arrival directions of cosmic rays above the
Greisen-Zatsepin-Kuz'min energy threshold, \nobreak{eV}. The
anisotropy was measured by the fraction of arrival directions that are less
than from the position of an active galactic nucleus within 75 Mpc
(using the V\'eron-Cetty and V\'eron catalog). An updated
measurement of this fraction is reported here using the arrival directions of
cosmic rays recorded above the same energy threshold through 31 December 2009.
The number of arrival directions has increased from 27 to 69, allowing a more
precise measurement. The correlating fraction is , compared
with expected for isotropic cosmic rays. This is down from the early
estimate of . The enlarged set of arrival directions is
examined also in relation to other populations of nearby extragalactic objects:
galaxies in the 2 Microns All Sky Survey and active galactic nuclei detected in
hard X-rays by the Swift Burst Alert Telescope. A celestial region around the
position of the radiogalaxy Cen A has the largest excess of arrival directions
relative to isotropic expectations. The 2-point autocorrelation function is
shown for the enlarged set of arrival directions and compared to the isotropic
expectation.Comment: Accepted for publication in Astroparticle Physics on 31 August 201
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